Search Results - "LAFONTAINE, A"

Smoke on the water: CO and H2O in a circumnuclear disc around a quasar at redshift 2.64 by Stacey, H R, Lafontaine, A, McKean, J P

“…ABSTRACT We present an analysis of observations with the Atacama Large (sub-)Millimetre Array (ALMA) of the 380 GHz water emission line and CO (11–10) emission…”
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Fluorescent riboswitch-controlled biosensors for the genome scale analysis of metabolic pathways by Michaud, A., Garneau, D., Côté, J.-P., Lafontaine, D. A.

“…Fluorescent detection in cells has been tremendously developed over the years and now benefits from a large array of reporters that can provide sensitive and…”
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A machine learning based approach to gravitational lens identification with the International LOFAR Telescope by Rezaei, S, McKean, J P, Biehl, M, de Roo, W, Lafontaine, A

“…ABSTRACT We present a novel machine learning based approach for detecting galaxy-scale gravitational lenses from interferometric data, specifically those taken…”
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Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms by Lemay, Jean-François, Desnoyers, Guillaume, Blouin, Simon, Heppell, Benoit, Bastet, Laurène, St-Pierre, Patrick, Massé, Eric, Lafontaine, Daniel A

“…Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-binding elements called riboswitches. Although they both bind…”
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Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile by Bordeleau, Eric, Purcell, Erin B, Lafontaine, Daniel A, Fortier, Louis-Charles, Tamayo, Rita, Burrus, Vincent

“…Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections with symptoms ranging from mild diarrhea to fulminant colitis…”
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Dual-acting riboswitch control of translation initiation and mRNA decay by Caron, Marie-Pier, Bastet, Laurène, Lussier, Antony, Simoneau-Roy, Maxime, Massé, Eric, Lafontaine, Daniel A

“…Riboswitches are mRNA regulatory elements that control gene expression by altering their structure in response to specific metabolite binding. In bacteria,…”
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Kernel-based testing for single-cell differential analysis by Ozier-Lafontaine, A, Fourneaux, C, Durif, G, Arsenteva, P, Vallot, C, Gandrillon, O, Gonin-Giraud, S, Michel, B, Picard, F

“…Single-cell technologies offer insights into molecular feature distributions, but comparing them poses challenges. We propose a kernel-testing framework for…”
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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways by Mulhbacher, Jérôme, Brouillette, Eric, Allard, Marianne, Fortier, Louis-Charles, Malouin, François, Lafontaine, Daniel A

“…Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch…”
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Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation by Chauvier, Adrien, Picard-Jean, Frédéric, Berger-Dancause, Jean-Christophe, Bastet, Laurène, Naghdi, Mohammad Reza, Dubé, Audrey, Turcotte, Pierre, Perreault, Jonathan, Lafontaine, Daniel A.

“…On the basis of nascent transcript sequencing, it has been postulated but never demonstrated that transcriptional pausing at translation start sites is…”
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Riboswitch and small RNAs modulate btuB translation initiation in Escherichia coli and trigger distinct mRNA regulatory mechanisms by Bastet, Laurène, Korepanov, Alexey P, Jagodnik, Jonathan, Grondin, Jonathan P, Lamontagne, Anne-Marie, Guillier, Maude, Lafontaine, Daniel A

“…Small RNAs (sRNAs) and riboswitches represent distinct classes of RNA regulators that control gene expression upon sensing metabolic or environmental…”
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A structural intermediate pre-organizes the add adenine riboswitch for ligand recognition by St-Pierre, Patrick, Shaw, Euan, Jacques, Samuel, Dalgarno, Paul A, Perez-Gonzalez, Cibran, Picard-Jean, Frédéric, Penedo, J Carlos, Lafontaine, Daniel A

“…Abstract Riboswitches are RNA sequences that regulate gene expression by undergoing structural changes upon the specific binding of cellular metabolites…”
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Investigating the role of RNA structures in transcriptional pausing using in vitro assays and in silico analyses by Jeanneau, Simon, Jacques, Pierre-Étienne, Lafontaine, Daniel A.

“…Transcriptional pausing occurs across the bacterial genome but the importance of this mechanism is still poorly understood. Only few pauses were observed…”
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Enhancing both motor and cognitive functioning in Parkinson’s disease: Aerobic exercise as a rehabilitative intervention by Duchesne, C., Lungu, O., Nadeau, A., Robillard, M.E., Boré, A., Bobeuf, F., Lafontaine, A.L., Gheysen, F., Bherer, L., Doyon, J.

“…•Three months of aerobic exercise training (AET) improves fitness in PD patients.•Effects of AET on cognitive and motor skills in PD were evaluated…”
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Maestro of regulation: Riboswitches orchestrate gene expression at the levels of translation, transcription and mRNA decay by Bastet, Laurène, Turcotte, Pierre, Wade, Joseph T., Lafontaine, Daniel A.

“…Riboswitches are RNA regulators that control gene expression by modulating their structure in response to metabolite binding. The study of mechanisms by which…”
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Gravitational lensing in LoTSS DR2: extremely faint 144-MHz radio emission from two highly magnified quasars by McKean, J P, Luichies, R, Drabent, A, Gürkan, G, Hartley, P, Lafontaine, A, Prandoni, I, Röttgering, H J A, Shimwell, T W, Stacey, H R, Tasse, C

“…ABSTRACT We report extremely faint 144 MHz radio emission from two gravitationally lensed quasars, SDSS J1004+4112 (z = 1.730) and SDSS J2222+2745 (z = 2.803),…”
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Inflammatory markers and BDNF in obstructive sleep apnea (OSA) in Parkinson's disease (PD) by Kaminska, M., O'Sullivan, M., Mery, V.P., Lafontaine, A.L., Robinson, A., Gros, P., Martin, J.G., Benedetti, A., Kimoff, R.J.

“…Obstructive sleep apnea (OSA) exacerbates Parkinson's disease (PD) manifestations including cognitive dysfunction. Both OSA and PD have been associated with…”
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Therapeutic applications of ribozymes and riboswitches by Mulhbacher, Jérôme, St-Pierre, Patrick, Lafontaine, Daniel A

“…Therapeutic approaches employing RNA as a tool or as a drug target have recently emerged and have been employed for various applications—ranging from cancer…”
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Folding of the SAM Aptamer is Determined by the Formation of a K-turn-dependent Pseudoknot by Heppell, Benoit, Lafontaine, Daniel A

“…The S-adenosylmethionine (SAM) riboswitch is one of the most recurrent riboswitches found in bacteria and has three known different natural aptamers. The…”
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Long-term efficacy of botulinum toxin A in treatment of various movement disorders over a 10-year period by Hsiung, G-Y.R., Das, S.K., Ranawaya, R., Lafontaine, A.-L., Suchowersky, O.

“…Although botulinum toxin A (BTX) has been licensed in Canada for treatment of various movement disorders since 1990, few clinical studies regarding its…”
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Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation by Blouin, Simon, Chinnappan, Raja, Lafontaine, Daniel A

“…The Bacillus subtilis lysC lysine riboswitch modulates its own gene expression upon lysine binding through a transcription attenuation mechanism. The…”
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