Search Results - "LAFONT, Virginie"

Pro-tumor γδ T Cells in Human Cancer: Polarization, Mechanisms of Action, and Implications for Therapy by Chabab, Ghita, Barjon, Clément, Bonnefoy, Nathalie, Lafont, Virginie

“…The tumor immune microenvironment contributes to tumor initiation, progression and response to therapy. Among the immune cell subsets that play a role in the…”
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Editorial: New insights into innate immune cell-based immunotherapies in cancer by Caignard, Anne, Poupot-Marsan, Mary, Lafont, Virginie, Wesch, Daniela, Porta, Chiara

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Editorial: Novel Strategies for Cancer Immunotherapy: Targeting Immune-Mediated Suppressive Mechanisms by Lafont, Virginie, Lucas, Sophie, Bonnefoy, Nathalie

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Differential role of autophagy in CD4 T cells and macrophages during X4 and R5 HIV-1 infection by Espert, Lucile, Varbanov, Mihayl, Robert-Hebmann, Véronique, Sagnier, Sophie, Robbins, Ian, Sanchez, Françoise, Lafont, Virginie, Biard-Piechaczyk, Martine

“…HIV-1 can infect and replicate in both CD4 T cells and macrophages. In these cell types, HIV-1 entry is mediated by the binding of envelope glycoproteins…”
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Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers by Chabab, Ghita, Boissière-Michot, Florence, Mollevi, Caroline, Ramos, Jeanne, Lopez-Crapez, Evelyne, Colombo, Pierre-Emmanuel, Jacot, William, Bonnefoy, Nathalie, Lafont, Virginie

“…γδ T-cells contribute to the immune response against many tumor types through their direct cytolytic functions and their capacity to recruit and regulate the…”
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IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population by Barjon, Clément, Michaud, Henri-Alexandre, Fages, Angeline, Dejou, Cécile, Zampieri, Alexandre, They, Laetitia, Gennetier, Aurélie, Sanchez, Françoise, Gros, Laurent, Eliaou, Jean-François, Bonnefoy, Nathalie, Lafont, Virginie

“…Vγ9Vδ2 T cells contribute to the immune response against many tumor types through their direct cytotoxic activity and capacity to regulate the biological…”
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Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization by Lafont, Virginie, Armstrong, Anthony A., Ohtaka, Hiroyasu, Kiso, Yoshiaki, Mario Amzel, L., Freire, Ernesto

“…A common strategy to improve the potency of drug candidates is to introduce chemical functionalities, like hydrogen bond donors or acceptors, at positions…”
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Full restoration of Brucella-infected dendritic cell functionality through Vγ9Vδ2 T helper type 1 crosstalk by Ni, Ming, Martire, Delphine, Scotet, Emmanuel, Bonneville, Marc, Sanchez, Francoise, Lafont, Virginie

“…Vγ9Vδ2 T cells play an important role in the immune response to infectious agents but the mechanisms contributing to this immune process remain to be better…”
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Radiosynthesis and preclinical PET evaluation of 89Zr-nivolumab (BMS-936558) in healthy non-human primates by Cole, Erin L., Kim, Joonyoung, Donnelly, David J., Smith, R. Adam, Cohen, Daniel, Lafont, Virginie, Morin, Paul E., Huang, Richard Y.-C., Chow, Patrick L., Hayes, Wendy, Bonacorsi, Samuel

“…[Display omitted] Cancer immunotherapy, unlike traditional cytotoxic chemotherapeutic treatments, engages the immune system to identify cancer cells and…”
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PD-1 blockade at the time of tumor escape potentiates the immune-mediated antitumor effects of a melanoma-targeting monoclonal antibody by They, Laetitia, Michaud, Henri-Alexandre, Becquart, Ondine, Lafont, Virginie, Guillot, Bernard, Boissière-Michot, Florence, Jarlier, Marta, Mollevi, Caroline, Eliaou, Jean-François, Bonnefoy, Nathalie, Gros, Laurent

“…Tumor antigen-targeting monoclonal antibodies (TA-targeting mAbs) are used as therapeutics in many malignancies and their capacity to mobilize the host…”
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IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines by Bessoles, Stéphanie, Fouret, Frédéric, Dudal, Sherri, Besra, Gurdyal S., Sanchez, Françoise, Lafont, Virginie

“…NKT cells belong to a conserved T lymphocyte subgroup that has been implicated in the regulation of various immune responses, including responses to viruses,…”
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Variations in Antigen−Antibody Association Kinetics as a Function of pH and Salt Concentration:  A QSAR and Molecular Modeling Study by Dejaegere, Annick, Choulier, Laurence, Lafont, Virginie, De Genst, Erwin, Altschuh, Danièle

“…The relationship between three environmental factors (ionic strength, pH, and temperature) and antigen−antibody binding kinetics was investigated using QSAR…”
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Vγ9Vδ2 T cells use a combination of mechanisms to limit the spread of the pathogenic bacteria Brucella by Oliaro, Jane, Dudal, Sherri, Liautard, Janny, Andrault, Jean‐Baptiste, Liautard, Jean‐Pierre, Lafont, Virginie

“…Human Vγ9Vδ2 T cells pay a crucial role in early immune response to intracellular pathogens. In brucellosis infection, this population of cells is drastically…”
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Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay by Ni, Yan G., Yuan, Xiling, Newitt, John A., Peterson, Jon E., Gleason, Carol R., Haulenbeek, Jonathan, Santockyte, Rasa, Lafont, Virginie, Marsilio, Frank, Neely, Robert J., DeSilva, Binodh, Piccoli, Steven P.

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Identification and Isolation of Brucella suis Virulence Genes Involved in Resistance to the Human Innate Immune System by Liautard, Janny, Ouahrani-Bettache, Safia, Jubier-Maurin, Véronique, Lafont, Virginie, Köhler, Stephan, Liautard, Jean-Pierre

“…Brucella strains are facultative intracellular pathogens that induce chronic diseases in humans and animals. This observation implies that Brucella subverts…”
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Impairment of Intramacrophagic Brucella suis Multiplication by Human Natural Killer Cells through a Contact-Dependent Mechanism by DORNAND, Jacques, LAFONT, Virginie, OLIARO, Jane, TERRAZA, Annie, CASTANEDA-ROLDAN, Elsa, LIAUTARD, Jean-Pierre

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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IL-21 Signaling in the Tumor Microenvironment by Chabab, Ghita, Bonnefoy, Nathalie, Lafont, Virginie

“…IL-21 is an immunomodulatory cytokine produced by natural killer (NK) cells and T cells that has pleiotropic roles in immune and nonimmune cells. IL-21 can…”
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Discovery of Novel, First-in-Class Allosteric Modulators of MALT1 Scaffolding Function with Differentiated Pharmacology for NFκB-Driven Malignancies by Yao, Yi, Bi, Yingzhi, Sun, Huadong, Ling, Kevin, Xia, Huili, Kuai, Jun, DePaolo, Patrick, Lafont, Virginie, Diller, David, Aslanian, Ara, Jaeger, Samira, Wahle, Joe, Liu, Wei, Carson, Ken, Reilly, Timothy, Harriman, Gerry, Wang, Fang

“…Constitutive activation of NFκB is an oncogenic driver for many lymphoid and selected solid tumor malignancies. BTK inhibitors, which affect the upstream NFκB…”
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Plasticity of γδ T Cells: Impact on the Anti-Tumor Response by Lafont, Virginie, Sanchez, Françoise, Laprevotte, Emilie, Michaud, Henri-Alexandre, Gros, Laurent, Eliaou, Jean-François, Bonnefoy, Nathalie

“…The tumor immune microenvironment contributes to tumor initiation, progression, and response to therapy. Among the immune cell subsets that play a role in the…”
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Single-cell high-dimensional imaging mass cytometry: one step beyond in oncology by Glasson, Yaël, Chépeaux, Laure-Agnès, Dumé, Anne-Sophie, Lafont, Virginie, Faget, Julien, Bonnefoy, Nathalie, Michaud, Henri-Alexandre

“…Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial, stromal, and immune) cell types constantly interact. Importantly, the…”
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