Search Results - "LAETHEM, Ronald M"

Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity by FAUCETTE, Stephanie R, HAWKE, Roy L, LECLUYSE, Edward L, SHORD, Stacy S, BINGFANG YAN, LAETHEM, Ronald M, LINDLEY, Celeste M

“…The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in vitro marker of cytochrome P450 (CYP) 2B6 catalytic activity. Among…”
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Centella asiatica Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions by Wright, Kirsten M, Magana, Armando Alcazar, Laethem, Ronald M, Moseley, Caroline L, Banks, Troy T, Maier, Claudia S, Stevens, Jan F, Quinn, Joseph F, Soumyanath, Amala

“…(CA) shows considerable promise for development as a botanical drug for cognitive decline. Its primary bioactive components include triterpene glycosides…”
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Toward Antibody-directed Enzyme Prodrug Therapy with the T268G Mutant of Human Carboxypeptidase A1 and Novel in VivoStable Prodrugs of Methotrexate by Smith, Gary K., Banks, Sheila, Blumenkopf, Todd A., Cory, Michael, Humphreys, Joan, Laethem, Ronald M., Miller, John, Moxham, Cary P., Mullin, Robert, Ray, Paul H., Walton, Leslie M., Wolfe, Lawrence A.

“…Antibody-directed enzyme prodrug therapy (ADEPT) has the potential of greatly enhancing antitumor selectivity of cancer therapy by synthesizing…”
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Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1 by LAETHEM, R. M, BALAZY, M, FALCK, J. R, LAETHEM, C. L, KOOP, D. R

“…When reconstituted with cytochrome b5 and NADPH cytochrome P450 oxidoreductase, cytochrome P450 2E1 metabolized lauric, stearic, oleic, linoleic, linolenic,…”
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Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate by Smith, G K, Banks, S, Blumenkopf, T A, Cory, M, Humphreys, J, Laethem, R M, Miller, J, Moxham, C P, Mullin, R, Ray, P H, Walton, L M, Wolfe, 3rd, L A

“…Antibody-directed enzyme prodrug therapy (ADEPT) has the potential of greatly enhancing antitumor selectivity of cancer therapy by synthesizing…”
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Increases in Neutral, Mg2+-Dependent and Acidic, Mg2+-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3–Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843 by Laethem, Ronald M., Hannun, Yusuf A., Jayadev, Supriya, Sexton, Connie J., Strum, Jay C., Sundseth, Rebecca, Smith, Gary K.

“…Thymidylate synthase (TS) inhibition causes cell death, and this enzyme is the target for the important chemotherapy regime 5-fluorouracil/leucovorin. GW1843…”
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A high throughput sphingomyelinase assay by Hassler, D F, Laethem, R M, Smith, G K

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Epoxidation of C18 unsaturated fatty acids by cytochromes P4502C2 and P4502CAA by Laethem, R M, Balazy, M, Koop, D R

“…The regioselective epoxidation of oleic, linoleic, alpha-linolenic, and gamma-linolenic acid by cytochromes P4502CAA and P4502C2 was characterized. Epoxide…”
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Identification of rabbit cytochromes P450 2C1 and 2C2 as arachidonic acid epoxygenases by Laethem, R M, Koop, D R

“…Microsomes prepared from COS-1 cells transiently expressing rabbit cytochromes P450 2C1 and 2C2 catalyzed the metabolism of arachidonic acid to predominantly…”
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Purification and properties of a cytochrome P450 arachidonic acid epoxygenase from rabbit renal cortex by LAETHEM, R. M, LAETHEM, C. L, KOOP, D. R

“…A rabbit cytochrome P450 which catalyzes the epoxidation of arachidonic acid to two of the four possible regioisomeric epoxyeicosatrienoic acid metabolites was…”
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Expression and Characterization of Human Pancreatic Preprocarboxypeptidase A1 and Preprocarboxypeptidase A2 by Laethem, Ronald M., Blumenkopf, Todd A., Cory, Michael, Elwell, Lynn, Moxham, Cary P., Ray, Paul H., Walton, Leslie M., Smith, Gary K.

“…We are investigating the potential utility of human carboxypeptidases A in antibody-directed enzyme prodrug therapy (ADEPT). Hybridization screening of a human…”
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Increases in Neutral, Mg2+-Dependent and Acidic, Mg2+-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3–Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843 by Laethem, Ronald M., Hannun, Yusuf A., Jayadev, Supriya, Sexton, Connie J., Strum, Jay C., Sundseth, Rebecca, Smith, Gary K.

“…Thymidylate synthase (TS) inhibition causes cell death, and this enzyme is the target for the important chemotherapy regime 5-fluorouracil/leucovorin. GW1843…”
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Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms by Laethem, R M, Halpert, J R, Koop, D R

“…In the present study we determined the regioselectivity of arachidonic acid epoxidation by several members of the cytochrome P-450 2B subfamily, including rat…”
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Cytochrome P450 expression and metabolism in isolated rabbit renal epithelium by Koop, D R, Laethem, R M, Goldner, A L, Douglas, J G

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