Search Results - "LADERO, J. M"

Leflunomide-induced acute hepatitis by Sevilla-Mantilla, C., Ortega, L., Agúndez, J.A.G., Fernández-Gutiérrez, B., Ladero, J.M., Dı́az-Rubio, M.

“…Leflunomide, a new immunomodulatory agent, was prescribed to a 67-year-old female patient with rheumatoid arthritis. Fifteen days later she developed diarrhoea…”
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Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk by AGUNDEZ, J. A. G, MARTINEZ, C, OLIVERA, M, GALLARDO, L, LADERO, J. M, ROSADO, C, PRADOS, J, RODRIGUEZ-MOLINA, J, RESEL, L, BENITEZ, J

“…The role of two common polymorphisms of enzymes involved in the metabolism of drugs and carcinogens was studied in relation to prostate cancer. The gene…”
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Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population by Agúndez, J A, Ledesma, M C, Ladero, J M, Benítez, J

“…The occurrence of multiple copies of the CYP2D6 gene was investigated 217 white healthy Spaniards by the combined use of Xba I and Eco RI restriction fragment…”
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Influence of polymorphic N-acetyltransferases on non-malignant spontaneous disorders and on response to drugs by Ladero, J M

“…Polymorphic N-acetyl transferases (NAT) 1 and 2 are involved in detoxification of xenobiotic arylamines and hydralazines. These common environmental chemicals…”
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High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population by GARCIA-MARTIN, Elena, MARTINEZ, Carmen, LADERO, José M, GAMITO, Francisco J. G, AGUNDEZ, José A. G

“…To search for ethnic variability in the impact of cytochrome P450 2C9 (CYP2C9) polymorphism. CYP2C9 allelic variants related to impaired CYP2C9 metabolism were…”
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Slow allotypic variants of the NAT2 gene and susceptibility to early-onset Parkinson's disease by AGUNDEZ, J. A. G, JIMENEZ-JIMENEZ, F. J, ALVAREZ-CERMENO, J. C, BENITEZ, J, LUENGO, A, MOLINA, J. A, ORTI-PAREJA, M, VAZQUEZ, A, RAMOS, F, DUARTE, J, CORIA, F, LADERO, J. M

“…To determine the frequency and the linkage distribution of seven mutations at the polymorphic gene coding for the arylamine N-acetyl transferase (NAT2; EC…”
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RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma by Ladero, J M, Agúndez, J A, Rodríguez-Lescure, A, Diaz-Rubio, M, Benítez, J

“…BACKGROUND: CYP2E1, the coding gene for the ethanol inducible cytochrome P4502E1, is polymorphic at the RsaI restriction site in the 5' flanking region. The…”
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N-Acetyltransferase 2 (NAT2) Genotype and Colorectal Carcinoma: Risk Variability According to Tumour Site? by AGUNDEZ, J. A. G, LOZANO, L, LADERO, J. M, SASTRE, J, CERDAN, F. J, DIAZ-RUBIO, M, BENITEZ, J

“…Background: Dietary heterocyclic aromatic amines (HAAs) are members of a family of chemicals that comprise highly mutagenic compounds related to colon cancer…”
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CYP2D6 genes and risk of liver cancer by Agúndez, J A, Ledesma, M C, Benítez, J, Ladero, J M, Rodríguez-Lescure, A, Díaz-Rubio, E, Díaz-Rubio, M

“…We have studied by use of PCR and XbaI and EcoRI restriction-fragment-length polymorphism whether mutations at the polymorphic CYP2D6 (debrisoquine…”
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N -Acetyltransferase 2 Polymorphism Is Not Related to the Risk of Advanced Alcoholic Liver Disease by Agúndez, J. A. G., Ladero, J. M., Olivera, M., Lozano, L., Fernández-Arquero, M., Concha, E. G. de la, Díaz-Rubio, M., Benítez, J.

“…Background: Ethanol abuse is the most prevalent cause of liver cirrhosis in Spain. Genetic polymorphisms affect the activity of the enzymes involved in ethanol…”
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Recurring hepatic hydrothorax: a difficult therapeutic challenge by Ladero, J M

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Hereditary hyperferritinemia-cataract syndrome. Study of a new family in Spain by Ladero, J M, Balas, A, García-Sánchez, F, Vicario, J L, Díaz-Rubio, M

“…The hyperferritinemia-cataract syndrome, inherited as a Mendelian dominant trait, is due to mutations in the 5' non-coding region of the ferritin light chain…”
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Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use by Martínez, Carmen, Blanco, Gerardo, Ladero, José M, García‐Martín, Elena, Taxonera, Carlos, Gamito, Francisco G, Diaz‐Rubio, Manuel, Agúndez, José A G

“…Impaired drug metabolism is a major cause of adverse drug reactions, and it is often caused by mutations at genes coding for drug‐metabolising enzymes. Two…”
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Acetylator polymorphism in human colorectal carcinoma by LADERO, J. M, GONZALEZ, J. F, BENITEZ, J, VARGAS, E, FERNANDEZ, M. J, BAKI, W, DIAZ-RUBIO, M

“…Acetylator phenotype has been determined using sulfamethazine in 109 patients histologically diagnosed with colorectal carcinoma (resected in 74 patients by…”
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The Role of Sonography in the Early Diagnosis of Biliopancreatic Ascaris Infestation by Larrubia, J R, Ladero, J M, Mendoza, J L, Morillas, J D, Diaz-Rubio, M

“…Acute pancreatitis due to ascaris lumbricoides infestation is extraordinarily uncommon in Europe. The diagnosis can be difficult because of the low index of…”
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Molecular analysis of the arylamine N-acetyltransferase polymorphism in a Spanish population by Agúndez, J A, Martínez, C, Olivera, M, Ledesma, M C, Ladero, J M, Benítez, J

“…The arylamine N-acetyltransferase (NAT-2) polymorphism causes impaired drug metabolism in about half of the white population. By the combined use of polymerase…”
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Genetic analysis of the arylamine N-acetyltransferase polymorphism in breast cancer patients by Agúndez, J A, Ladero, J M, Olivera, M, Abildúa, R, Román, J M, Benítez, J

“…The association of the arylamine N-acetyltransferase polymorphism and breast cancer has been investigated by analysis of genomic DNA from 160 breast cancer…”
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Oxidative polymorphism of debrisoquine in Parkinson's disease by Benitez, J, Ladero, J M, Jimenez-Jimenez, F J, Martinez, C, Puerto, A M, Valdivielso, M J, Llerena, A, Cobaleda, J, Muñoz, J J

“…Oxidative phenotype and metabolic ratio (MR) of debrisoquine (DBQ) have been determined in 87 patients with Parkinson's disease and in 556 healthy control…”
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Cigarette Smoking, N-Acetyltransferase 2 Acetylation Status, and Bladder Cancer Risk: A Case-Series Meta-analysis of a Gene-Environment Interaction by Marcus, P M, Hayes, R B, Vineis, P, Garcia-Closas, M, Caporaso, N E, Autrup, H, Branch, R A, Brockmöller, J, Ishizaki, T, Karakaya, A E, Ladero, J M, Mommsen, S, Okkels, H, Romkes, M, Roots, I, Rothman, N

“…Tobacco use is an established cause of bladder cancer. The ability to detoxify aromatic amines, which are present in tobacco and are potent bladder…”
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CYP2D6 genotypes in Spanish women with breast cancer by Ladona, Margarita G., Abildúa, Rosa E., Ladero, JoséM., Román, JoséM., Plaza, María A., Agúndez, JoséA.G., Muñoz, Juan J., Beníez, Julio

“…Wild type and three mutated alleles of the polymorphic CYP2D6 gene were studied in genomic DNA samples from 187 women with breast carcinoma and 151 healthy…”
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