Search Results - "LADERACH, Diego J"
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A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease
Published in Cancer research (Chicago, Ill.) (2013)“…Galectins, a family of glycan-binding proteins, influence tumor progression by modulating interactions between tumor, endothelial, stromal, and immune cells…”
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Galectin-1 Triggers Epithelial-Mesenchymal Transition in Human Hepatocellular Carcinoma Cells
Published in Journal of cellular physiology (01-06-2015)“…Galectin‐1 (Gal1), a β‐galactoside‐binding protein abundantly expressed in tumor microenvironments, is associated with the development of metastasis in…”
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Dissecting the signal transduction pathways triggered by galectin–glycan interactions in physiological and pathological settings
Published in IUBMB life (01-01-2010)“…Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified…”
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Delineating the "galectin signature" of the tumor microenvironment
Published in Oncoimmunology (01-04-2013)“…Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a…”
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Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers
Published in Prostate Cancer (01-01-2013)“…A better understanding of multimolecular interactions involved in tumor dissemination is required to identify new effective therapies for advanced prostate…”
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In Vivo Hemin Conditioning Targets the Vascular and Immunologic Compartments and Restrains Prostate Tumor Development
Published in Clinical cancer research (01-09-2017)“…Conditioning strategies constitute a relatively unexplored and exciting opportunity to shape tumor fate by targeting the tumor microenvironment. In this study,…”
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Glycans and galectins in prostate cancer biology, angiogenesis and metastasis
Published in Glycobiology (Oxford) (01-10-2014)“…Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. While localized prostate cancer can…”
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Study of galectins in tumor immunity: strategies and methods
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2015)“…During the past decade, a better understanding of the cellular and molecular mechanisms underlying tumor immunity has provided the appropriate framework for…”
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Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2015)“…Formation of an aberrant and heterogeneous vascular network is a key pathological event in the multistep process of tumor growth and metastasis. Pro-angiogenic…”
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Abstract 3960: Low doses of Docetaxel in combination with anti-prostate cancer immunotherapy lead to complete tumor-free outcome through Galectin-3 silencing
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Based on animal model results and the analysis of clinical data from metastatic and castration resistant prostate cancer (mCRPC) patients, we were able to…”
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Abstract 453: Engineering the tumor microenvironment: Hemin conditioning in vivo impairs tumor growth and reprograms the immune-modulatory response in prostate cancer
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States, and inflammation is recognized as a risk factor. In this regard…”
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