Search Results - "LACOURCIERE, Yves"

Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study by Ruilope, Luis Miguel, Prof, Dukat, Andrej, Prof, Böhm, Michael, Prof, Lacourcière, Yves, MD, Gong, Jianjian, PhD, Lefkowitz, Martin P, MD

“…Summary Background LCZ696 is a first-in-class inhibitor of the angiotensin II receptor and neprilysin. We aimed to establish whether the dual actions of LCZ696…”
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Triple Antihypertensive Therapy With Amlodipine, Valsartan, and Hydrochlorothiazide: A Randomized Clinical Trial by Calhoun, David A, Lacourcière, Yves, Chiang, Yann Tong, Glazer, Robert D

“…Many patients with hypertension require ≥3 agents to achieve target blood pressure (BP). The efficacy/safety of the dual combinations of valsartan…”
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β-Blockers in Hypertension: Studies and Meta-analyses Over the Years by Larochelle, Pierre, MD, PhD, Tobe, Sheldon W., MD, MScCH (HPTE), FRCPC, FACP, FASH, Lacourcière, Yves, MD

“…Abstract β-Blockers are among the most commonly used medications in the treatment of hypertension. However, 45 years after their initial indication for that…”
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Telmisartan or Valsartan Alone or in Combination with Hydrochlorothiazide: A Review by Lacourcière, Yves

“…The aim of this review was to compare telmisartan and valsartan in the treatment of hypertension. PubMed searches were conducted to identify randomized trials…”
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The Evolving Role of β-Adrenergic Receptor Blockers in Managing Hypertension by Poirier, Luc, BPharm, MSc, Lacourcière, Yves, MD, FRCPC, FACP

“…Abstract β-Adrenergic blocking agents (or β-blockers) have been widely used for the treatment of hypertension for the past 50 years, and continue to be…”
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Clinic and ambulatory blood pressure lowering effect of aliskiren/amlodipine/hydrochlorothiazide combination in patients with moderate-to-severe hypertension: a randomized active-controlled trial by Lacourcière, Yves, Taddei, Stefano, Konis, George, Fang, Hui, Severin, Thomas, Zhang, Jack

“…OBJECTIVES:To evaluate the clinic and ambulatory blood pressure (BP)-lowering efficacy and safety of an aliskiren/amlodipine/hydrochlorothiazide (HCT) triple…”
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Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study by Sharma, Arya M, Davidson, Jaime, Koval, Stephen, Lacourcière, Yves

“…The Study of Micardis (telmisartan) in Overweight/Obese patients with Type 2 diabetes and Hypertension (SMOOTH) compared hydrochlorothiazide (HCTZ) plus…”
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Effects of demographics on the antihypertensive efficacy of triple therapy with amlodipine, valsartan, and hydrochlorothiazide for moderate to severe hypertension by Calhoun, David A., Lacourcière, Yves, Crikelair, Nora, Jia, Yan, Glazer, Robert D.

“…Abstract Objective: To compare the antihypertensive efficacy and safety of once-daily triple therapy with amlodipine (Aml) 10 mg, valsartan (Val) 320 mg, and…”
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Augmentation Index and Central Aortic Stiffness in Middle-Aged to Elderly Individuals by Vyas, Mitul, Izzo, Joseph L., Lacourcière, Yves, Arnold, J. Malcolm O., Dunlap, Mark E., Amato, Jennifer L., Pfeffer, Marc A., Mitchell, Gary F.

“…Increased aortic stiffness contributes to systolic hypertension and increased cardiovascular risk. The augmentation index (AI), ie, the percentage of central…”
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Increasing the doses of both diuretics and angiotensin receptor blockers is beneficial in subjects with uncontrolled systolic hypertension by Lacourcière, Yves, MD, Poirier, Luc, BPharm MSc, Lefebvre, Jean, PhD, Ross, Stuart A., MD, Leenen, Frans H., MD PhD

“…Background Blood pressure (BP) control is frequently difficult to achieve in patients with predominantly elevated systolic BP. Consequently, these patients…”
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The effect of telmisartan and ramipril on early morning blood pressure surge: a pooled analysis of two randomized clinical trials by Gosse, Philippe, Neutel, Joel M, Schumacher, Helmut, Lacourcière, Yves, Williams, Bryn, Davidai, Giora

“…The period of early morning blood pressure surge is associated with a higher incidence of cardiovascular events than at other times of the day…”
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Effects of force-titrated valsartan/hydrochlorothiazide versus amlodipine/hydrochlorothiazide on ambulatory blood pressure in patients with stage 2 hypertension: the EVALUATE study by Lacourcière, Yves, Wright, Jr, Jackson T, Samuel, Rita, Zappe, Dion, Purkayastha, Das, Black, Henry R

“…Previous studies using the combination of angiotensin-receptor blockers and hydrochlorothiazide (HCTZ) have shown superior ambulatory blood pressure (ABP)…”
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24‐Hour Ambulatory Blood Pressure Response to Combination Valsartan/Hydrochlorothiazide and Amlodipine/Hydrochlorothiazide in Stage 2 Hypertension by Ethnicity: The EVALUATE Study by Wright Jr, Jackson T., Lacourcière, Yves, Samuel, Rita, Zappe, Dion, Purkayastha, Das, Black, Henry R.

“…J Clin Hypertens (Greenwich). Several studies reported racial/ethnic differences in blood pressure (BP) response to antihypertensive monotherapy. In a 10‐week…”
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Aortic Diameter, Wall Stiffness, and Wave Reflection in Systolic Hypertension by Mitchell, Gary F, Conlin, Paul R, Dunlap, Mark E, Lacourcière, Yves, Arnold, J Malcolm O, Ogilvie, Richard I, Neutel, Joel, Izzo, Joseph L, Pfeffer, Marc A

“…Systolic hypertension is associated with increased pulse pressure (PP) and increased risk for adverse cardiovascular outcomes. However the pathogenesis of…”
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Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension by Lacourcière, Yves, MD, Poirier, Luc, BPharm MSc, Lefebvre, Jean, BPharm MSc

“…Objectives The present study investigated whether initiating therapy with a combination of losartan (L) and hydrochlorothiazide (HCTZ) allows for faster blood…”
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Effects of graded-release diltiazem versus ramipril, dosed at bedtime, on early morning blood pressure, heart rate, and the rate-pressure product by White, William B., Lacourciere, Yves, Gana, Theophilus, Pascual, Maria G., Smith, David H., Albert, Kenneth S.

“…Therapeutic agents for the treatment of hypertension may differ in their efficacy during the early morning period, a time when both morbid and mortal…”
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Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial by Solomon, Scott D, Dr, Janardhanan, Rajesh, MD, Verma, Anil, MD, Bourgoun, Mikhail, MD, Daley, William L, MD, Purkayastha, Das, PhD, Lacourcière, Yves, MD, Hippler, Stephen E, MD, Fields, Harold, MD, Naqvi, Tasneem Z, MD, Mulvagh, Sharon L, MD, Arnold, J Malcolm O, MD, Thomas, James D, MD, Zile, Michael R, MD, Aurigemma, Gerard P, MD

“…Summary Background Diastolic dysfunction might represent an important pathophysiological intermediate between hypertension and heart failure. Our aim was to…”
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Determinants of elevated pulse pressure in middle-aged and older subjects with uncomplicated systolic hypertension: The role of proximal aortic diameter and the aortic pressure-flow relationship by MITCHELL, Gary F, LACOURCIERE, Yves, OUELLET, Jean-Pascal, IZZO, Joseph L, NEUTEL, Joel, KERWIN, Linda J, BLOCK, Alan J, PFEFFER, Marc A

“…Elevated pulse pressure (PP) is associated with increased cardiovascular risk and is thought to be secondary to elastin fragmentation with secondary collagen…”
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Principal Results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) Trial by Black, Henry R, Elliott, William J, Grandits, Gregory, Grambsch, Patricia, Lucente, Tracy, White, William B, Neaton, James D, Grimm, Jr, Richard H, Hansson, Lennart, Lacourcière, Yves, Muller, James, Sleight, Peter, Weber, Michael A, Williams, Gordon, Wittes, Janet, Zanchetti, Alberto, Anders, Robert J

“…CONTEXT Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is…”
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Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: Results of the conduit hemodynamics of omapatrilat international research study by MITCHELL, Gary F, IZZO, Joseph L, LACOURCIERE, Yves, OUELLET, Jean-Pascal, NEUTEL, Joel, CHUNLIN QIAN, KERWIN, Linda J, BLOCK, Alan J, PFEFFER, Marc A

“…Increased pulse pressure, an indicator of conduit vessel stiffness, is a strong independent predictor of cardiovascular events in hypertensive cohorts, which…”
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