Search Results - "LACKNER, Andrew"

Type 3 innate lymphoid cell depletion is mediated by TLRs in lymphoid tissues of simian immunodeficiency virus‐infected macaques by Xu, Huanbin, Wang, Xiaolei, Lackner, Andrew A., Veazey, Ronald S.

“…ABSTRACT Innate lymphoid cells (ILCs) type 3, also known as lymphoid tissue inducer cells, plays a major role in both the development and remodeling of…”
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CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells by Micci, Luca, Alvarez, Xavier, Iriele, Robin I, Ortiz, Alexandra M, Ryan, Emily S, McGary, Colleen S, Deleage, Claire, McAtee, Brigitte B, He, Tianyu, Apetrei, Cristian, Easley, Kirk, Pahwa, Savita, Collman, Ronald G, Derdeyn, Cynthia A, Davenport, Miles P, Estes, Jacob D, Silvestri, Guido, Lackner, Andrew A, Paiardini, Mirko

“…In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent…”
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In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis by Gautam, Uma S., Foreman, Taylor W., Bucsan, Allison N., Veatch, Ashley V., Alvarez, Xavier, Adekambi, Toidi, Golden, Nadia A., Gentry, Kaylee M., Doyle-Meyers, Lara A., Russell-Lodrigue, Kasi E., Didier, Peter J., Blanchard, James L., Kousoulas, K. Gus, Lackner, Andrew A., Kalman, Daniel, Rengarajan, Jyothi, Khader, Shabaana A., Kaushal, Deepak, Mehra, Smriti

“…Mycobacterium tuberculosis continues to cause devastating levels of mortality due to tuberculosis (TB). The failure to control TB stems from an incomplete…”
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Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells by Xu, Huanbin, Wang, Xiaolei, Malam, Naomi, Aye, Pyone P, Alvarez, Xavier, Lackner, Andrew A, Veazey, Ronald S

“…CD4(+) follicular T helper (Tfh) cells play a prominent role in humoral immune responses, but the mechanisms of their accumulation and infection in AIDS remain…”
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Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques by Liu, Li, Wei, Qiang, Alvarez, Xavier, Wang, Haibo, Du, Yanhua, Zhu, Hua, Jiang, Hong, Zhou, Jingying, Lam, Pokman, Zhang, Linqi, Lackner, Andrew, Qin, Chuan, Chen, Zhiwei

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis by Kaushal, Deepak, Foreman, Taylor W., Gautam, Uma S., Alvarez, Xavier, Adekambi, Toidi, Rangel-Moreno, Javier, Golden, Nadia A., Johnson, Ann-Marie F., Phillips, Bonnie L., Ahsan, Muhammad H., Russell-Lodrigue, Kasi E., Doyle, Lara A., Roy, Chad J., Didier, Peter J., Blanchard, James L., Rengarajan, Jyothi, Lackner, Andrew A., Khader, Shabaana A., Mehra, Smriti

“…Tuberculosis (TB) is a global pandaemic, partially due to the failure of vaccination approaches. Novel anti-TB vaccines are therefore urgently required. Here…”
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Nonhuman Primate Models and Understanding the Pathogenesis of HIV Infection and AIDS by Veazey, Ronald S, Lackner, Andrew A

“…Abstract Research using nonhuman primates (NHPs) as models for human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) has…”
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Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques by Mohan, Mahesh, Kumar, Vinay, Lackner, Andrew A, Alvarez, Xavier

“…Persistent gastrointestinal inflammation, a hallmark of progressive HIV/SIV infection, causes disruption of the gastrointestinal epithelial barrier, microbial…”
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Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS by Xu, Huanbin, Wang, Xiaolei, Malam, Naomi, Lackner, Andrew A, Veazey, Ronald S

“…CD4(+) T follicular helper (Tfh) cells are critical for the generation of humoral immune responses to pathogenic infections, providing help for B cell…”
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Translational Research in the Nonhuman Primate Model of Tuberculosis by Foreman, Taylor W, Mehra, Smriti, Lackner, Andrew A, Kaushal, Deepak

“…Abstract Infection with Mycobacterium tuberculosis predominantly establishes subclinical latent infection over the lifetime of an individual, with a fraction…”
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CD4⁺ T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection by Foreman, Taylor W., Mehra, Smriti, LoBato, Denae N., Malek, Adel, Alvarez, Xavier, Golden, Nadia A., Bucşan, Allison N., Didier, Peter J., Doyle-Meyers, Lara A., Russell-Lodrigue, Kasi E., Roy, Chad J., Blanchard, James, Kuroda, Marcelo J., Lackner, Andrew A., Chan, John, Khader, Shabaana A., Jacobs, William R., Kaushal, Deepak

“…The synergy between Mycobacterium tuberculosis (Mtb) and HIV in coinfected patients has profoundly impacted global mortality because of tuberculosis (TB) and…”
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The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence by Mehra, Smriti, Foreman, Taylor W, Didier, Peter J, Ahsan, Muhammad H, Hudock, Teresa A, Kissee, Ryan, Golden, Nadia A, Gautam, Uma S, Johnson, Ann-Marie, Alvarez, Xavier, Russell-Lodrigue, Kasi E, Doyle, Lara A, Roy, Chad J, Niu, Tianhua, Blanchard, James L, Khader, Shabaana A, Lackner, Andrew A, Sherman, David R, Kaushal, Deepak

“…Hypoxia promotes dormancy by causing physiologic changes to actively replicating Mycobacterium tuberculosis. DosR controls the response of M. tuberculosis to…”
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The Role of Defensins in HIV Pathogenesis by Pahar, Bapi, Porter, Edith, Lackner, Andrew A., Pace, Barcley T.

“…Profound loss of CD4+ T cells, progressive impairment of the immune system, inflammation, and sustained immune activation are the characteristics of human…”
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The stress-response factor SigH modulates the interaction between Mycobacterium tuberculosis and host phagocytes by Dutta, Noton K, Mehra, Smriti, Martinez, Alejandra N, Alvarez, Xavier, Renner, Nicole A, Morici, Lisa A, Pahar, Bapi, Maclean, Andrew G, Lackner, Andrew A, Kaushal, Deepak

“…The Mycobacterium tuberculosis stress response factor SigH plays a crucial role in modulating the pathogen's response to heat, oxidative-stress, envelope…”
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Granuloma Correlates of Protection Against Tuberculosis and Mechanisms of Immune Modulation by Mycobacterium tuberculosis by Mehra, Smriti, Alvarez, Xavier, Didier, Peter J., Doyle, Lara A., Blanchard, James L., Lackner, Andrew A., Kaushal, Deepak

“…Background. The BCG vaccine is ineffective against adult tuberculosis. Hence, new antituberculosis vaccines are needed. Correlates of protection against…”
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Genetic Requirements for the Survival of Tubercle Bacilli in Primates by Dutta, Noton K., Mehra, Smriti, Didier, Peter J., Roy, Chad J., Doyle, Lara A., Alvarez, Xavier, Ratterree, Marion, Be, Nicholas A., Lamichhane, Gyanu, Jain, Sanjay K., Lacey, Michelle R., Lackner, Andrew A., Kaushal, Deepak

“…Background. Tuberculosis (TB) leads to the death of 1.7 million people annually. The failure of the bacille Calmette-Guérin vaccine, synergy between AIDS and…”
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Recently Infiltrating MAC387+ Monocytes/ Macrophages: A Third Macrophage Population Involved in SIV and HIV Encephalitic Lesion Formation by SOULAS, Caroline, CONERLY, Cecily, KIM, Woong-Ki, BURDO, Tricia H, ALVAREZ, Xavier, LACKNER, Andrew A, WILLIAMS, Kenneth C

“…Monocytes/macrophages are critical components of HIV and SIV encephalitic lesions. We used in vivo BrdU labeling and markers specific to stages of macrophage…”
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The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis by McKenna, Philip, Hoffmann, Christian, Minkah, Nana, Aye, Pyone Pyone, Lackner, Andrew, Liu, Zongzhi, Lozupone, Catherine A, Hamady, Micah, Knight, Rob, Bushman, Frederic D

“…The vertebrate gut harbors a vast community of bacterial mutualists, the composition of which is modulated by the host immune system. Many gastrointestinal…”
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The Gastrointestinal Tract and AIDS Pathogenesis by Lackner, Andrew A, Mohan, Mahesh, Veazey, Ronald S

“…Gastrointestinal disease has been recognized as a major manifestation of human immunodeficiency virus infection since the earliest recognition of acquired…”
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Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development by Sugimoto, Chie, Hasegawa, Atsuhiko, Saito, Yohei, Fukuyo, Yayoi, Chiu, Kevin B, Cai, Yanhui, Breed, Matthew W, Mori, Kazuyasu, Roy, Chad J, Lackner, Andrew A, Kim, Woong-Ki, Didier, Elizabeth S, Kuroda, Marcelo J

“…Monocyte and dendritic cell (DC) development was evaluated using in vivo BrdU pulse-chase analyses in rhesus macaques, and phenotype analyses of these cells in…”
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