Search Results - "LACASSE, E. C"

Detachment-induced upregulation of XIAP and cIAP2 delays anoikis of intestinal epithelial cells by LIU, Z, LI, H, ROSEN, K. V, WU, X, YOO, B. H, YAN, S. R, STADNYK, A. W, SASAZUKI, T, SHIRASAWA, S, LACASSE, E. C, KORNELUK, R. G

“…Detachment of normal epithelial cells from the extracellular matrix triggers apoptosis, a phenomenon called anoikis. Conversely, carcinoma cells tend to be…”
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IAP-targeted therapies for cancer by LaCasse, E C, Mahoney, D J, Cheung, H H, Plenchette, S, Baird, S, Korneluk, R G

“…DNA damage, chromosomal abnormalities, oncogene activation, viral infection, substrate detachment and hypoxia can all trigger apoptosis in normal cells…”
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Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins by LaCasse, Eric C., Lefebvre, Yvonne A.

“…Many proteins are composed of modular domains with each domain being derived from a sequence of amino acid residues that forms a distinctive structure…”
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Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation by Mahoney, D.J, Cheung, H.H, Mrad, R. Lejmi, Plenchette, S, Simard, C, Enwere, E, Arora, V, Mak, T.W, Lacasse, E.C, Waring, J, Korneluk, R.G

“…The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated in the activation of NF-κB by TNFα; however, genetic deletion of…”
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Shiga-like toxin-1 receptor on human breast cancer, lymphoma, and myeloma and absence from CD34+ hematopoietic stem cells : Implications for ex vivo tumor purging and autologous stem cell transplantation by LACASSE, E. C, BRAY, M. R, MILLER, N, BANERJEE, D, SINGH, D, BELCH, A. R, PILARSKI, L. M, GARIEPY, J, PATTERSON, B, LIM, W.-M, PERAMPALAM, S, RADVANYI, L. G, KEATING, A, STEWART, A. K, BUCKSTEIN, R, SANDHU, J. S

“…The ribosome-inactivating protein, Shiga-like toxin-1 (SLT-1), targets cells that express the glycolipid globotriaosylceramide (CD77) on their surface. CD77…”
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The inhibitors of apoptosis (IAPs) and their emerging role in cancer by LaCasse, E C, Baird, S, Korneluk, R G, MacKenzie, A E

“…The inhibitor of apoptosis protein family has been characterized over the past 5 years, initially in baculovirus and more recently in metazoans. The IAPs are a…”
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Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics by MCMANUS, Dan C, LEFEBVRE, Charles A, CHERTON-HORVAT, Gabriele, ST-JEAN, Martine, KANDIMALLA, Ekambar R, AGRAWAL, Sudhir, MORRIS, Stephen J, DURKIN, Jon P, LACASSE, Eric C

“…Stable expression of short-hairpin RNAs (shRNAs) directed against the X-linked inhibitor of apoptosis (XIAP) resulted in the generation of three MDA-MB-231…”
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Shiga-like toxin purges human lymphoma from bone marrow of severe combined immunodeficient mice by LACASSE, E. C, SALEH, M. T, PATTERSON, B, MINDEN, M. D, GARIEPY, J

“…Shiga-like toxin-1 (SLT-1) is a bacterial toxin that kills cells by inhibiting protein synthesis. SLT-1 is composed of one cytotoxic A-subunit and five…”
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Identification of binding proteins for nuclear localization signals of the glucocorticoid and thyroid hormone receptors by LaCasse, E C, Lochnan, H A, Walker, P, Lefebvre, Y A

“…Nuclear entry of proteins the size of the glucocorticoid and thyroid hormone receptors appears to be mediated by an interaction of nuclear localization signals…”
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Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome by Seidl, R, Bajo, M, Böhm, K, LaCasse, E C, MacKenzie, A E, Cairns, N, Lubec, G

“…In Down syndrome (DS), enhanced apoptosis (programmed cell death) may play a role in the pathogenesis of characteristic early mental retardation and precocious…”
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Microsomal dexamethasone binding sites identified by affinity labelling by LaCasse, E C, Howell, G M, Lefebvre, Y A

“…Binding studies with [3H]dexamethasone identified a class of binding sites on male rat liver microsomes. The binding sites were glucocorticoid-dependent and…”
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Penetration and Intracellular Routing of Nucleus-Directed Peptide-Based Shuttles (Loligomers) in Eukaryotic Cells by Singh, Devender, Kiarash, Reza, Kawamura, Kim, LaCasse, Eric C, Gariépy, Jean

“…Loligomers are multitasking, peptide-based shuttles that are able to penetrate cells and self-localize into distinct cellular compartments. In particular,…”
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Evidence for Apoptosis in the Fetal Down Syndrome Brain by Seidl, Rainer, Bidmon, Bettina, Bajo, Michael, Yoo, Byon C., Cairns, Nigel, LaCasse, Eric C., Lubec, Gert

“…In Down syndrome, enhanced apoptosis (programmed cell death) may play a role in the pathogenesis of characteristic early mental retardation and precocious…”
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Nuclear and nuclear envelope binding proteins of the glucocorticoid receptor nuclear localization peptide identified by crosslinking by LaCasse, E C, Lefebvre, Y A

“…The molecular mechanisms underlying the nuclear entry of steroid receptors and possible regulation of steroid hormone action during receptor passage across the…”
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LAP-targeted therapies for cancer: Apoptosis - Part 1 by LACASSE, E. C, MAHONEY, D. J, CHEUNG, H. H, PLENCHETTE, S, BAIRD, S, KORNELUK, R. G

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Identification of binding proteins for nuclear localization signals of the glucocorticoid and thyroid hormone receptors by LaCasse, E C, Lochnan, H A, Walker, P, Lefebvre, Y A

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Both cIAP1 and cIAP2 regulate TNF[alpha]-mediated NF-[kappa]B activation by Mahoney, D J, Cheung, H H, Mrad, R Lejmi, Plenchette, S, Simard, C, Enwere, E, Arora, V, Mak, T W, Lacasse, E C, Waring, J, Korneluk, R G

“…The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated in the activation of NF-...B by TNFagr; however, genetic deletion…”
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Both cIAP1 and cIAP2 regulate TNFa-mediated NF-B activation by Mahoney, D J, Cheung, H H, Mrad, RLejmi, Plenchette, S, Simard, C, Enwere, E, Arora, V, Mak, T W, Lacasse, E C, Waring, J, Korneluk, R G

“…The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated in the activation of NF-B by TNFa; however, genetic deletion of…”
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Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo by Hu, YanPing, Cherton-Horvat, Gabriele, Dragowska, Visia, Baird, Stephen, Korneluk, Robert G, Durkin, Jon P, Mayer, Lawrence D, LaCasse, Eric C

“…Activation of programmed cell death in cancer cells offers novel and potentially useful approaches to improving patient responses to conventional chemotherapy…”
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Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640 by LACASSE, ERIC C., KANDIMALLA, EKAMBAR R., WINOCOUR, PETER, SULLIVAN, TIM, AGRAWAL, SUDHIR, GILLARD, JOHN W., DURKIN, JON

“…Targeting apoptosis control provides a novel therapeutic approach to the treatment of cancer and other proliferative disorders. We summarize the evidence for…”
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