Search Results - "LACAL, Juan C"

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors by Mazarico, José M, Sánchez-Arévalo Lobo, Victor J, Favicchio, Rosy, Greenhalf, William, Costello, Eithne, Carrillo-de Santa Pau, Enrique, Marqués, Miriam, Lacal, Juan C, Aboagye, Eric, Real, Francisco X

“…Choline kinase α (CHKα) plays a crucial role in the regulation of membrane phospholipid synthesis and has oncogenic properties in vitro. We have analyzed the…”
Get full text

The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy by AL-SAFFAR, Nada M. S, JACKSON, L. Elizabeth, RAYNAUD, Florence I, CLARKE, Paul A, DE MOLINA, Ana Ramirez, LACAL, Juan C, WORKMAN, Paul, LEACH, Martin O

“…The phosphoinositide 3-kinase (PI3K) pathway is a major target for cancer drug development. PI-103 is an isoform-selective class I PI3K and mammalian target of…”
Get full text

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models by AL-SAFFAR, Nada M. S, TROY, Helen, CHUNG, Yuen-Li, RAMIREZ DE MOLINA, Ana, JACKSON, Laura E, MADHU, Basetti, GRIFFITHS, John R, LEACH, Martin O, WORKMAN, Paul, LACAL, Juan C, JUDSON, Ian R

“…MN58b is a novel anticancer drug that inhibits choline kinase, resulting in inhibition of phosphocholine synthesis. The aim of this work was to develop a…”
Get full text

Symmetrical Bis-Quinolinium Compounds:  New Human Choline Kinase Inhibitors with Antiproliferative Activity against the HT-29 Cell Line by Sánchez-Martín, Rosario, Campos, Joaquín M, Conejo-García, Ana, Cruz-López, Olga, Báñez-Coronel, Mónica, Rodríguez-González, Agustín, Gallo, Miguel A, Lacal, Juan C, Espinosa, Antonio

“…Studies have been aimed at the establishment of structure−activity relationships that define choline kinase inhibitory and antiproliferative activities of 40…”
Get full text

Choline kinase inhibitory effect and antiproliferative activity of new 1,1′,1″-(benzene-1,3,5-triylmethylene)tris{4-[(disubstituted)amino]pyridinium} tribromides by Conejo-Garcı́a, Ana, Campos, Joaquı́n, Sánchez, Rosario M, Rodrı́guez-González, Agustı́n, Lacal, Juan C, Gallo, Miguel A, Espinosa, Antonio

“…Four derivatives of 1,1′-(benzene-1,3-diylmethylene)bis{4-[(disubstituted)amino]-pyridinium} dibromides ( 2– 5) and six derivatives of…”
Get full text

Signaling from G Protein-coupled Receptors to the c-jun Promoter Involves the MEF2 Transcription Factor by Coso, Omar A., Montaner, Silvia, Fromm, Christian, Lacal, Juan C., Prywes, Ron, Teramoto, Hidemi, Gutkind, J. Silvio

“…The c-Jun amino-terminal kinases (JNKs) are a subfamily of mitogen-activated protein kinases that phosphorylate c-Jun and ATF2, and it has been postulated that…”
Get full text

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells by Chua, Boon Tin, Gallego-Ortega, David, Ramirez de Molina, Ana, Ullrich, Axel, Lacal, Juan Carlos, Downward, Julian

“…The serine/threonine kinase PKB/Akt plays essential role in various cellular processes including cell growth and proliferation, metabolism and cell survival…”
Get full text

Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides by Conejo-García, Ana, Campos, Joaquín, Sánchez, Rosario M, Rodríguez-González, Agustín, Lacal, Juan C, Gallo, Miguel A, Espinosa, Antonio

“…Four derivatives of 1,1'-(benzene-1,3-diylmethylene)bis[4-[(disubstituted)amino]-pyridinium] dibromides (2-5) and six derivatives of…”
Get full text

Potentiation of oncogenic N-ras-induced neurite outgrowth and ornithine decarboxylase activity by phorbol dibutyrate and protein kinase inhibitor H-8 by Trotta, R J, Thomson, T M, Lacal, J C, Pellicer, A, Burstein, D E

“…A recombinant N-ras oncogene, under the transcriptional control of a corticosteroid-inducible mouse mammary tumor virus (MMTV) promoter, has been stably…”
Get more information