Search Results - "LABURTHE, Marc"

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR Review 1 by Harmar, Anthony J, Fahrenkrug, Jan, Gozes, Illana, Laburthe, Marc, May, Victor, Pisegna, Joseph R, Vaudry, David, Vaudry, Hubert, Waschek, James A, Said, Sami I

“…Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase‐activating polypeptide (PACAP) are members of a superfamily of structurally related peptide…”
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Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease by Fasseu, Magali, Tréton, Xavier, Guichard, Cécile, Pedruzzi, Eric, Cazals-Hatem, Dominique, Richard, Christophe, Aparicio, Thomas, Daniel, Fanny, Soulé, Jean-Claude, Moreau, Richard, Bouhnik, Yoram, Laburthe, Marc, Groyer, André, Ogier-Denis, Eric

“…Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory Bowel Diseases (IBD) affecting the intestinal mucosa. Current understanding of…”
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The family B1 GPCR: structural aspects and interaction with accessory proteins by Couvineau, Alain, Laburthe, Marc

“…G protein coupled receptors (GPCRs) play a crucial role in physiology and pathophysiology in humans. Beside the large family A (rhodopsin-like receptors) and…”
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Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology by Laburthe, Marc, Couvineau, Alain, Tan, Var

“…VIP and PACAP impact strongly on human pathophysiology. Their receptors are very promising targets for developing new drugs in the treatment of inflammatory…”
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Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis by VOISIN, Thierry, EI FIRAR, Aadil, LABURTHE, Marc, FASSEU, Magali, ROUYER-FESSARD, Christiane, DESCATOIRE, Véronique, WALKER, Francine, PARADIS, Valerie, BEDOSSA, Pierre, HENIN, Dominique, LEHY, Thérèse

“…Resistance to apoptosis is a recurrent theme in colon cancer. We have shown previously that the 7-transmembrane spanning receptor OX1R for orexins promotes…”
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Molecular and Conformational Determinants of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) for Activation of the PAC1 Receptor by Bourgault, Steve, Vaudry, David, Ségalas-Milazzo, Isabelle, Guilhaudis, Laure, Couvineau, Alain, Laburthe, Marc, Vaudry, Hubert, Fournier, Alain

“…PAC1 receptor is abundant in the CNS and plays an important role in neuronal survival. To identify the molecular determinants and the conformational components…”
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Novel Receptor Partners and Function of Receptor Activity-modifying Proteins by Christopoulos, Arthur, Christopoulos, George, Morfis, Maria, Udawela, Madhara, Laburthe, Marc, Couvineau, Alain, Kuwasako, Kenji, Tilakaratne, Nanda, Sexton, Patrick M

“…The receptor activity-modifying proteins (RAMPs) comprise a family of three accessory proteins that heterodimerize with the calcitonin receptor-like receptor…”
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Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer Cells by Darmoul, Dalila, Gratio, Valérie, Devaud, Hélène, Lehy, Thérèse, Laburthe, Marc

“…The traditional view on the role of serine proteases in tumor biology has changed with the recent discovery of a family of protease-activated receptors (PARs)…”
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Class-B GPCR activation: is ligand helix-capping the key? by Neumann, Jean-Michel, Couvineau, Alain, Murail, Samuel, Lacapère, Jean-Jacques, Jamin, Nadège, Laburthe, Marc

“…The class B family of G-protein-coupled receptors (GPCRs) regulates essential physiological functions such as exocrine and endocrine secretions, feeding…”
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Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis by El Firar, Aadil, Voisin, Thierry, Rouyer-Fessard, Christiane, Ostuni, Mariano A, Couvineau, Alain, Laburthe, Marc

“…The orexin neuropeptides promote robust apoptosis in cancer cells. We have recently shown that the 7-transmembrane-spanning orexin receptor OX1R mediates…”
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Orexin-Induced Apoptosis: The Key Role of the Seven-Transmembrane Domain Orexin Type 2 Receptor by Voisin, Thierry, Firar, Aadil El, Avondo, Virgile, Laburthe, Marc

“…Orexin-A and orexin-B are regulatory peptides involved in the control of feeding, sleep-wakefulness, and exerting various endocrine and metabolic actions…”
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Activation of Proteinase-Activated Receptor 1 Promotes Human Colon Cancer Cell Proliferation Through Epidermal Growth Factor Receptor Transactivation by Darmoul, Dalila, Gratio, Valérie, Devaud, Hélène, Peiretti, Franck, Laburthe, Marc

“…Serine proteases are now considered as crucial contributors to the development of human colon cancer. We have shown recently that thrombin is a potent growth…”
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Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways by DUCROC, Robert, VOISIN, Thierry, EL FIRAR, Aadil, LABURTHE, Marc

“…Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways Robert Ducroc , Thierry Voisin , Aadil El Firar…”
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PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine by Buyse, M, Berlioz, F, Guilmeau, S, Tsocas, A, Voisin, T, Péranzi, G, Merlin, D, Laburthe, M, Lewin, M J, Rozé, C, Bado, A

“…Dietary proteins are mostly absorbed as di- and tripeptides by the intestinal proton-dependent transporter PepT1. We have examined the effects of leptin on…”
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Orexins Acting at Native OX1 Receptor in Colon Cancer and Neuroblastoma Cells or at Recombinant OX1 Receptor Suppress Cell Growth by Inducing Apoptosis by Patricia Rouet-Benzineb, Christiane Rouyer-Fessard, Anne Jarry, Virgile Avondo, Cécile Pouzet, Masashi Yanagisawa, Christian Laboisse, Marc Laburthe, Thierry Voisin

“…Screening of 26 gut peptides for their ability to inhibit growth of human colon cancer HT29-D4 cells grown in 10% fetal calf serum identified orexin-A and…”
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VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins by Couvineau, Alain, Laburthe, Marc

“…The vasoactive intestinal peptide (VIP) is a neuropeptide with wide distribution in both central and peripheral nervous systems, where it plays important…”
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PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: Involvement of the mitochondrial apoptotic pathway by Aubert, Nicolas, Vaudry, David, Falluel-Morel, Anthony, Desfeux, Arnaud, Fisch, Cécile, Ancian, Philippe, de Jouffrey, Stéphane, Le Bigot, Jean-François, Couvineau, Alain, Laburthe, Marc, Fournier, Alain, Laudenbach, Vincent, Vaudry, Hubert, Gonzalez, Bruno J

“…Abstract Cisplatin is a chemotherapeutic agent whose use is limited by side effects including neuropathies. In proliferating cells, toxic action of cisplatin…”
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Diffuse Pharmacophoric Domains of Vasoactive Intestinal Peptide (VIP) and Further Insights into the Interaction of VIP with the N-terminal Ectodomain of Human VPAC1 Receptor by Photoaffinity Labeling with [Bpa6]-VIP by Tan, Yossan-Var, Couvineau, Alain, Laburthe, Marc

“…The widespread 28-amino acid neuropeptide vasoactive intestinal peptide (VIP) exerts its many biological effects through interaction with serpentine class II G…”
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Photoaffinity Labeling Demonstrates Physical Contact between Vasoactive Intestinal Peptide and the N-terminal Ectodomain of the Human VPAC1 Receptor by Tan, Yossan-Var, Couvineau, Alain, Van Rampelbergh, Jean, Laburthe, Marc

“…Vasoactive intestinal peptide (VIP) is a prominent neuropeptide whose actions are mediated by VPAC receptors belonging to class II G protein-coupled receptors…”
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M1184 Specific Alteration of MicroRNA Expression in Inflammatory Bowel Disease by Treton, Xavier, Fasseu, Magali, Bouhnik, Yoram, Soulé, Jean Claude, Thomas, Aparicio, Cazals-Hatem, Dominique, Laburthe, Marc C, Ogier-Denis, Eric

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