Search Results - "LABRECQUE, P"

Cabozantinib can block growth of neuroendocrine prostate cancer patient-derived xenografts by disrupting tumor vasculature by Labrecque, Mark P, Brown, Lisha G, Coleman, Ilsa M, Nguyen, Holly M, Lin, Daniel W, Corey, Eva, Nelson, Peter S, Morrissey, Colm

“…With the advent of potent second-line anti-androgen therapy, we and others have observed an increased incidence of androgen receptor (AR)-null small cell or…”
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Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines by Labrecque, Mark P, Takhar, Mandeep K, Hollingshead, Brett D, Prefontaine, Gratien G, Perdew, Gary H, Beischlag, Timothy V

“…The activated AHR/ARNT complex (AHRC) regulates the expression of target genes upon exposure to environmental contaminants such as…”
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Epigenetic characterization of the growth hormone gene identifies SmcHD1 as a regulator of autosomal gene clusters by Massah, Shabnam, Hollebakken, Robert, Labrecque, Mark P, Kolybaba, Addie M, Beischlag, Timothy V, Prefontaine, Gratien G

“…Regulatory elements for the mouse growth hormone (GH) gene are located distally in a putative locus control region (LCR) in addition to key elements in the…”
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The aryl hydrocarbon receptor nuclear translocator (ARNT) family of proteins: transcriptional modifiers with multi-functional protein interfaces by Labrecque, M P, Prefontaine, G G, Beischlag, T V

“…The basic Helix-Loop-Helix/PER-ARNT-SIM (bHLH-PAS) domain family of transcription factors mediates cellular responses to a variety of internal and external…”
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Retinoblastoma protein (Rb) links hypoxia to altered mechanical properties in cancer cells as measured by an optical tweezer by Khakshour, S., Labrecque, M. P., Esmaeilsabzali, H., Lee, F. J. S., Cox, M. E., Park, E. J., Beischlag, T. V.

“…Hypoxia modulates actin organization via multiple pathways. Analyzing the effect of hypoxia on the biophysical properties of cancer cells is beneficial for…”
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Thromboxane A2 modulates cisplatin-induced apoptosis through a Siva1-dependent mechanism by Iorio-Morin, C, Germain, P, Roy, S, Génier, S, Labrecque, P, Parent, J-L

“…Thromboxane A 2 (TXA 2 ) is an important lipid mediator whose function in apoptosis is the subject of conflicting reports. Here, a yeast two-hybrid screen for…”
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A TRIP230-retinoblastoma protein complex regulates hypoxia-inducible factor-1α-mediated transcription and cancer cell invasion by Labrecque, Mark P, Takhar, Mandeep K, Jagdeo, Julienne M, Tam, Kevin J, Chiu, Christina, Wang, Te-Yu, Prefontaine, Gratien G, Cox, Michael E, Beischlag, Timothy V

“…Localized hypoxia in solid tumors activates transcriptional programs that promote the metastatic transformation of cells. Like hypoxia-inducible…”
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Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer by Labrecque, Mark P, Coleman, Ilsa M, Brown, Lisha G, True, Lawrence D, Kollath, Lori, Lakely, Bryce, Nguyen, Holly M, Yang, Yu C, da Costa, Rui M Gil, Kaipainen, Arja, Coleman, Roger, Higano, Celestia S, Yu, Evan Y, Cheng, Heather H, Mostaghel, Elahe A, Montgomery, Bruce, Schweizer, Michael T, Hsieh, Andrew C, Lin, Daniel W, Corey, Eva, Nelson, Peter S, Morrissey, Colm

“…Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic…”
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Fate and transport of bromide and mononuclear aromatic hydrocarbons in aqueous solutions through Berea Sandstone by Labrecque, Steven P., Blanford, William J.

“…A series of miscible displacement tests were performed on a 51 mm wide by 76 mm long well-laminated core of Berea Sandstone to determine the transport…”
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The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approaches by Labrecque, Mark P, Alumkal, Joshi J, Coleman, Ilsa M, Nelson, Peter S, Morrissey, Colm

“…The use of androgen deprivation therapy and second-line anti-androgens in prostate cancer has led to the emergence of tumors employing multiple androgen…”
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Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer by DeLucia, Diana C, Cardillo, Thomas M, Ang, Lisa, Labrecque, Mark P, Zhang, Ailin, Hopkins, James E, De Sarkar, Navonil, Coleman, Ilsa, da Costa, Rui M Gil, Corey, Eva, True, Lawrence D, Haffner, Michael C, Schweizer, Michael T, Morrissey, Colm, Nelson, Peter S, Lee, John K

“…Neuroendocrine prostate cancer (NEPC) is an aggressive form of castration-resistant prostate cancer (CRPC) for which effective therapies are lacking. We…”
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Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts by Lam, Hung-Ming, Nguyen, Holly M., Labrecque, Mark P., Brown, Lisha G., Coleman, Ilsa M., Gulati, Roman, Lakely, Bryce, Sondheim, Daniel, Chatterjee, Payel, Marck, Brett T., Matsumoto, Alvin M., Mostaghel, Elahe A., Schweizer, Michael T., Nelson, Peter S., Corey, Eva

“…Androgen deprivation therapy improves the survival of castration-resistant prostate cancer (CRPC) patients, yet ultimately fails with debilitating side…”
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Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1 by Lee, Martin, Wang, Christine, Jin, Steven W., Labrecque, Mark P., Beischlag, Timothy V., Brockman, Mark A., Choy, Jonathan C.

“…The production of nitric oxide (NO) by inducible NO synthase (iNOS) and the regulation of gene expression by hypoxia-inducible factors (HIFs) are important for…”
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BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program by Kim, Dae-Hwan, Sun, Duanchen, Storck, William K, Welker Leng, Katherine, Jenkins, Chelsea, Coleman, Daniel J, Sampson, David, Guan, Xiangnan, Kumaraswamy, Anbarasu, Rodansky, Eva S, Urrutia, Joshua A, Schwartzman, Jacob A, Zhang, Chao, Beltran, Himisha, Labrecque, Mark P, Morrissey, Colm, Lucas, Jared M, Coleman, Ilsa M, Nelson, Peter S, Corey, Eva, Handelman, Samuel K, Sexton, Jonathan Z, Aggarwal, Rahul, Abida, Wassim, Feng, Felix Y, Small, Eric J, Spratt, Daniel E, Bankhead, 3rd, Armand, Rao, Arvind, Gesner, Emily M, Attwell, Sarah, Lakhotia, Sanjay, Campeau, Eric, Yates, Joel A, Xia, Zheng, Alumkal, Joshi J

“…Lineage plasticity in prostate cancer-most commonly exemplified by loss of androgen receptor (AR) signaling and a switch from a luminal to alternate…”
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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer by Labrecque, Mark P, Brown, Lisha G, Coleman, Ilsa M, Lakely, Bryce, Brady, Nicholas J, Lee, John K, Nguyen, Holly M, Li, Dapei, Hanratty, Brian, Haffner, Michael C, Rickman, David S, True, Lawrence D, Lin, Daniel W, Lam, Hung-Ming, Alumkal, Joshi J, Corey, Eva, Nelson, Peter S, Morrissey, Colm

“…Neuroendocrine (NE) differentiation in metastatic castration-resistant prostate cancer (mCRPC) is an increasingly common clinical feature arising from cellular…”
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Targeting the fibroblast growth factor pathway in molecular subtypes of castration‐resistant prostate cancer by Labrecque, Mark P., Brown, Lisha G., Coleman, Ilsa M., Nguyen, Holly M., Dalrymple, Susan, Brennen, W. Nathaniel, Isaacs, John T., Li, Dapei, Lakely, Bryce, DeLucia, Diana C., Lee, John K., Schweizer, Michael T., Lin, Daniel W., Corey, Eva, Nelson, Peter S., Morrissey, Colm

“…Background Androgen receptor (AR) pathway inhibition remains the cornerstone for prostate cancer therapies. However, castration‐resistant prostate cancer…”
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p,p′-Dichlorodiphenyltrichloroethane (p,p′-DDT) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) repress prostate specific antigen levels in human prostate cancer cell lines by Wong, Lilian I.L., Labrecque, Mark P., Ibuki, Naokazu, Cox, Michael E., Elliott, John E., Beischlag, Timothy V.

“…•pp′-DDT and pp′-DDE repress androgen induced PSA expression in prostate cancer cell lines.•pp′-DDT and pp′-DDE prevent androgen receptor occupancy at the PSA…”
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The retinoblastoma protein regulates hypoxia-inducible genetic programs, tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells by Labrecque, Mark P., Takhar, Mandeep K., Nason, Rebecca, Santacruz, Stephanie, Tam, Kevin J., Massah, Shabnam, Haegert, Anne, Bell, Robert H., Altamirano-Dimas, Manuel, Collins, Colin C., Lee, Frank J.S., Prefontaine, Gratien G., Cox, Michael E., Beischlag, Timothy V.

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Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers by Zhang, Ailin, Lau, Nathan A, Wong, Alicia, Brown, Lisha G, Coleman, Ilsa M, De Sarkar, Navonil, Li, Dapei, DeLucia, Diana C, Labrecque, Mark P, Nguyen, Holly M, Conner, Jennifer L, Dumpit, Ruth F, True, Lawrence D, Lin, Daniel W, Corey, Eva, Alumkal, Joshi J, Nelson, Peter S, Morrissey, Colm, Lee, John K

“…Castration-resistant prostate cancer (CRPC) consists of multiple phenotypic subtypes including androgen receptor (AR)-active prostate cancer (ARPC) and…”
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Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity by Perdew, Gary H, Hollingshead, Brett D, Dinatale, Brett C, Morales, J Luis, Labrecque, Mark P, Takhar, Mandeep K, Tam, Kevin J, Beischlag, Timothy V

“…The putative cardioprotective and chemopreventive properties of the red wine phenolic resveratrol (RES) have made it the subject of a growing body of clinical…”
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