Search Results - "LABEIKOVSKY, WLADIMIR"

Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer’s disease with metabolic syndrome by Tyagi, Alpna, Musa, Musa, Labeikovsky, Wladimir, Pugazhenthi, Subbiah

“…SIRT3 deacetylates mitochondrial proteins, thereby enhancing their function. We have previously demonstrated that Sirt3 gene deletion leads to brain…”
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Molecular Mechanism of Pin1–Tau Recognition and Catalysis by Eichner, Timo, Kutter, Steffen, Labeikovsky, Wladimir, Buosi, Vanessa, Kern, Dorothee

“…Human peptidyl-prolyl isomerase (PPIase) Pin1 plays key roles in developmental processes, cell proliferation, and neuronal function. Extensive phosphorylation…”
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MSCAT: A Machine Learning Assisted Catalog of Metabolomics Software Tools by Dekermanjian, Jonathan, Labeikovsky, Wladimir, Ghosh, Debashis, Kechris, Katerina

“…The bottleneck for taking full advantage of metabolomics data is often the availability, awareness, and usability of analysis tools. Software tools…”
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Intrinsic dynamics of an enzyme underlies catalysis by Millet, Oscar, Labeikovsky, Wladimir, Bosco, Daryl A, Eisenmesser, Elan Z, Korzhnev, Dmitry M, Wolf-Watz, Magnus, Skalicky, Jack J, Kern, Dorothee, Kay, Lewis E

“…A unique feature of chemical catalysis mediated by enzymes is that the catalytically reactive atoms are embedded within a folded protein. Although current…”
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Structure and Dynamics of Pin1 During Catalysis by NMR by Labeikovsky, Wladimir, Eisenmesser, Elan Z., Bosco, Daryl A., Kern, Dorothee

“…The link between internal enzyme motions and catalysis is poorly understood. Correlated motions in the microsecond-to-millisecond timescale may be critical for…”
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Changes in the mitochondrial proteome from mouse hearts deficient in creatine kinase by KERNEC, FLORENCE, UNLU, MUSTAFA, LABEIKOVSKY, WLADIMIR, MINDEN, JONATHAN S, KORETSKY, ALAN P

“…1 Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 2 Carnegie Mellon…”
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Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein by Gardino, Alexandra K., Villali, Janice, Kivenson, Aleksandr, Lei, Ming, Liu, Ce Feng, Steindel, Phillip, Eisenmesser, Elan Z., Labeikovsky, Wladimir, Wolf-Watz, Magnus, Clarkson, Michael W., Kern, Dorothee

“…Phosphorylation is a common mechanism for activating proteins within signaling pathways. Yet, the molecular transitions between the inactive and active…”
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Solution Characterization of the Extracellular Region of CD147 and Its Interaction with Its Enzyme Ligand Cyclophilin A by Schlegel, Jennifer, Redzic, Jasmina S., Porter, Christopher C., Yurchenko, Vyacheslav, Bukrinsky, Michael, Labeikovsky, Wladimir, Armstrong, Geoffrey S., Zhang, Fengli, Isern, Nancy G., DeGregori, James, Hodges, Robert, Eisenmesser, Elan Zohar

“…The CD147 receptor plays an integral role in numerous diseases by stimulating the expression of several protein families and serving as the receptor for…”
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Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the Biological HIV-1 Capsid Substrate by NMR by Bosco, Daryl A., Eisenmesser, Elan Zohar, Clarkson, Michael W., Wolf-Watz, Magnus, Labeikovsky, Wladimir, Millet, Oscar, Kern, Dorothee

“…Peptidyl–prolyl isomerases (PPIases) are emerging as key regulators of many diverse biological processes. Elucidating the role of PPIase activity in vivo has…”
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Mesodynamics in the SARS nucleocapsid measured by NMR field cycling by Clarkson, Michael W, Lei, Ming, Eisenmesser, Elan Z, Labeikovsky, Wladimir, Redfield, Alfred, Kern, Dorothee

“…Protein motions on all timescales faster than molecular tumbling are encoded in the spectral density. The dissection of complex protein dynamics is typically…”
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Dissecting the microscopic steps of the cyclophilin a enzymatic cycle on the biological substrate HIV-capsid by NMR by Bosco, Daryl A, Eisenmesser, Elan Zohar, Clarkson, Michael W, Wolf-Watz, Magnus, Labeikovsky, Wladimir, Millet, Oscar, Kern, Dorothee

“…Peptidyl-prolyl isomerases (PPIases) are emerging as key regulators of many diverse biological processes. Elucidating the role of PPIase activity in vivo has…”
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Proline isomerase dynamics and the modulation of Tau function by Pin1 by Labeikovsky, Wladimir

“…Peptidyl-prolyl isomerases (PPIases) constitute a superfamily of enzymes that catalyze the cis/trans isomerization of prolyl bonds. A number of natural…”
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