Search Results - "LABAN, Sandra"

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes by Kracht, Maria J L, van Lummel, Menno, Nikolic, Tatjana, Joosten, Antoinette M, Laban, Sandra, van der Slik, Arno R, van Veelen, Peter A, Carlotti, Françoise, de Koning, Eelco J P, Hoeben, Rob C, Zaldumbide, Arnaud, Roep, Bart O

“…Use of an alternative open reading frame, potentially as a result of cellular stress, drives production of an unconventional insulin epitope that is recognized…”
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Induction of Treg by monocyte-derived DC modulated by vitamin D₃ or dexamethasone: Differential role for PD-L1 by Unger, Wendy W.J, Laban, Sandra, Kleijwegt, Fleur S, van der Slik, Arno R, Roep, Bart O

“…Specific therapy with modulated DC may restore immunological tolerance, thereby obviating the need for chronic immunosuppression in transplantation or…”
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Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus by Laban, Sandra, Suwandi, Jessica S, van Unen, Vincent, Pool, Jos, Wesselius, Joris, Höllt, Thomas, Pezzotti, Nicola, Vilanova, Anna, Lelieveldt, Boudewijn P F, Roep, Bart O

“…Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these…”
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Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients by Nikolic, Tatjana, Suwandi, Jessica S, Wesselius, Joris, Laban, Sandra, Joosten, Antoinette M, Sonneveld, Petra, Mul, Dick, Aanstoot, Henk-Jan, Kaddis, John S, Zwaginga, Jaap Jan, Roep, Bart O

“…Restoration of immune tolerance may halt progression of autoimmune diseases. Tolerogenic dendritic cells (tolDC) inhibit antigen-specific proinflammatory…”
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Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry by van der Zwan, Anita, van Unen, Vincent, Beyrend, Guillaume, Laban, Sandra, van der Keur, Carin, Kapsenberg, Hanneke J M, Höllt, Thomas, Chuva de Sousa Lopes, Susana M, van der Hoorn, Marie-Louise P, Koning, Frits, Claas, Frans H J, Eikmans, Michael, Heidt, Sebastiaan

“…During healthy pregnancy, a balanced microenvironment at the maternal-fetal interface with coordinated interaction between various immune cells is necessary to…”
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Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice by Unger, Wendy W J, Pearson, Todd, Abreu, Joana R F, Laban, Sandra, van der Slik, Arno R, der Kracht, Sacha Mulder-van, Kester, Michel G D, Serreze, Dave V, Shultz, Leonard D, Griffioen, Marieke, Drijfhout, Jan Wouter, Greiner, Dale L, Roep, Bart O

“…Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells,…”
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TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program by Chamorro, Sonia, Garcia-Vallejo, Juan J, Unger, Wendy W. J, Fernandes, Rosette J, Bruijns, Sven C. M, Laban, Sandra, Roep, Bart O, t Hart, Bert A, van Kooyk, Yvette

“…Tolerogenic dendritic cells (TDC) offer a promising therapeutic potential to ameliorate autoimmune diseases. Reported to inhibit adaptive immune responses,…”
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Induction of Treg by monocyte‐derived DC modulated by vitamin D 3 or dexamethasone: Differential role for PD‐L1 by Unger, Wendy W. J., Laban, Sandra, Kleijwegt, Fleur S., van der Slik, Arno R., Roep, Bart O.

“…Specific therapy with modulated DC may restore immunological tolerance, thereby obviating the need for chronic immunosuppression in transplantation or…”
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β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1 by Thomaidou, Sofia, Kracht, Maria J L, van der Slik, Arno, Laban, Sandra, de Koning, Eelco J, Carlotti, Francoise, Hoeben, Rob C, Roep, Bart O, Zaldumbide, Arnaud

“…The signal peptide of preproinsulin is a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)-mediated β-cell destruction in type 1…”
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T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex by Beringer, Dennis X, Kleijwegt, Fleur S, Wiede, Florian, van der Slik, Arno R, Loh, Khai Lee, Petersen, Jan, Dudek, Nadine L, Duinkerken, Gaby, Laban, Sandra, Joosten, Antoinette, Vivian, Julian P, Chen, Zhenjun, Uldrich, Adam P, Godfrey, Dale I, McCluskey, James, Price, David A, Radford, Kristen J, Purcell, Anthony W, Nikolic, Tatjana, Reid, Hugh H, Tiganis, Tony, Roep, Bart O, Rossjohn, Jamie

“…To date, structural analysis has demonstrated a highly consistent binding pattern of the TCR to the MHC molecule. Rossjohn and colleagues reveal the first…”
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Helminth infections drive heterogeneity in human type 2 and regulatory cells by de Ruiter, Karin, Jochems, Simon P, Tahapary, Dicky L, Stam, Koen A, König, Marion, van Unen, Vincent, Laban, Sandra, Höllt, Thomas, Mbow, Moustapha, Lelieveldt, Boudewijn P F, Koning, Frits, Sartono, Erliyani, Smit, Johannes W A, Supali, Taniawati, Yazdanbakhsh, Maria

“…Helminth infections induce strong type 2 and regulatory responses, but the degree of heterogeneity of such cells is not well characterized. Using mass…”
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Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells by Kleijwegt, Fleur S, Laban, Sandra, Duinkerken, Gaby, Joosten, Antoinette M, Zaldumbide, Arnaud, Nikolic, Tatjana, Roep, Bart O

“…TNF is a pleiotropic cytokine with differential effects on immune cells and diseases. Anti-TNF therapy was shown to be effective in rheumatoid arthritis but…”
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Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes by Claessens, Laura A., Wesselius, Joris, van Lummel, Menno, Laban, Sandra, Mulder, Flip, Mul, Dick, Nikolic, Tanja, Aanstoot, Henk-Jan, Koeleman, Bobby P. C., Roep, Bart O.

“…Aims/hypothesis Heterogeneity in individuals with type 1 diabetes has become more generally appreciated, but has not yet been extensively and systematically…”
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A unique immune signature in blood separates therapy-refractory from therapy-responsive acute graft-versus-host disease by van Halteren, Astrid G. S., Suwandi, Jessica S., Tuit, Sander, Borst, Jelske, Laban, Sandra, Tsonaka, Roula, Struijk, Ada, Wiekmeijer, Anna-Sophia, van Pel, Melissa, Roep, Bart O., Zwaginga, Jaap Jan, Lankester, Arjan C., Schepers, Koen, van Tol, Maarten J. D., Fibbe, Willem E.

“…•aGVHD triggers the generation of CD11b+CD163+ monocytes and TCRαβ+ or TCRγδ+ effector T cells with skin- or gut-homing properties.•Additional CD11b– dendritic…”
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1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications by van Megen, Kayleigh M., Chen, Zhuo, Joosten, Antoinette M., Laban, Sandra, Zwaginga, Jaap-Jan, Natarajan, Rama, Nikolic, Tatjana, Roep, Bart O.

“…Autologous, antigen-specific, tolerogenic dendritic cells (tolDCs) are presently assessed to reverse and possibly cure autoimmune diseases such as type 1…”
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GPA33 is expressed on multiple human blood cell types and distinguishes CD4+ central memory T cells with and without effector function by Opstelten, Rianne, Suwandi, Jessica S, Slot, Manon C., Morgana, Florencia, Scott, Andrew M, Laban, Sandra, Nikolic, Tatjana, Turksma, Annelies W, Kroeze, Anna, Voermans, Carlijn, Zwaginga, Jaap‐Jan, Roep, Bart O, Amsen, Derk

“…The Ig superfamily protein glycoprotein A33 (GPA33) has been implicated in immune dysregulation, but little is known about its expression in the immune…”
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Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule by van Lummel, Menno, van Veelen, Peter A, de Ru, Arnoud H, Pool, Jos, Nikolic, Tatjana, Laban, Sandra, Joosten, Antoinette, Drijfhout, Jan W, Gómez-Touriño, Iria, Arif, Sefina, Aanstoot, Henk J, Peakman, Mark, Roep, Bart O

“…HLA-DQ2/8 heterozygous individuals are at far greater risk for type 1 diabetes (T1D) development by expressing HLA-DQ8trans on antigen-presenting cells…”
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Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells by Kleijwegt, Fleur S, Laban, Sandra, Duinkerken, Gaby, Joosten, Antoinette M, Koeleman, Bobby P C, Nikolic, Tatjana, Roep, Bart O

“…Infectious tolerance is a term generally assigned to the process through which regulatory T cells (Tregs) transfer immunoregulatory properties to other T…”
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Multidimensional analyses of proinsulin peptide-specific regulatory T cells induced by tolerogenic dendritic cells by Suwandi, Jessica S., Laban, Sandra, Vass, Kincsὅ, Joosten, Antoinette, van Unen, Vincent, Lelieveldt, Boudewijn P.F., Höllt, Thomas, Zwaginga, Jaap Jan, Nikolic, Tatjana, Roep, Bart O.

“…Induction of antigen-specific regulatory T cells (Tregs) in vivo is the holy grail of current immune-regulating therapies in autoimmune diseases, such as type…”
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Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR by van Lummel, Menno, van Veelen, Peter A, de Ru, Arnoud H, Janssen, George M C, Pool, Jos, Laban, Sandra, Joosten, Antoinette M, Nikolic, Tatjana, Drijfhout, Jan W, Mearin, M Luisa, Aanstoot, Henk J, Peakman, Mark, Roep, Bart O

“…Identifying T cell epitopes of islet autoantigens is important for understanding type 1 diabetes (T1D) immunopathogenesis and to design immune monitoring and…”
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