Search Results - "LAAGE, Rico"

Monitoring regulated protein-protein interactions using split TEV by Laage, Rico, Rossner, Moritz J, Wehr, Michael C, Bolz, Ulrike, Fischer, Tobias M, Grünewald, Sylvia, Scheek, Sigrid, Bach, Alfred, Nave, Klaus-Armin

“…Signaling cascades integrate extracellular stimuli primarily through regulated protein-protein interactions (PPIs). Intracellular signal transduction strictly…”
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A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF) by Schäbitz, Wolf-Rüdiger, Krüger, Carola, Pitzer, Claudia, Weber, Daniela, Laage, Rico, Gassler, Nikolaus, Aronowski, Jaroslaw, Mier, Walter, Kirsch, Friederike, Dittgen, Tanjew, Bach, Alfred, Sommer, Clemens, Schneider, Armin

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine responsible for the proliferation, differentiation, and maturation of…”
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Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injury by Dittgen, Tanjew, Pitzer, Claudia, Plaas, Christian, Kirsch, Friederike, Vogt, Gerhard, Laage, Rico, Schneider, Armin

“…Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured…”
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Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis by Pitzer, Claudia, Krüger, Carola, Plaas, Christian, Kirsch, Friederike, Dittgen, Tanjew, Müller, Ralph, Laage, Rico, Kastner, Stefan, Suess, Stefanie, Spoelgen, Robert, Henriques, Alexandre, Ehrenreich, Hannelore, Schäbitz, Wolf-Rüdiger, Bach, Alfred, Schneider, Armin

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results in progressive loss of motoneurons, motor weakness and death within…”
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Early Brain Volume Changes After Stroke: Subgroup Analysis From the AXIS-2 Trial by Bu, Ning, Churilov, Leonid, Khlif, Mohamed Salah, Lemmens, Robin, Wouters, Anke, Fiebach, Jochen B, Chamorro, Angel, Ringelstein, E Bernd, Norrving, Bo, Laage, Rico, Grond, Martin, Wilms, Guido, Brodtmann, Amy, Thijs, Vincent

“…The evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain…”
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First‐in‐human, randomized, double‐blind, placebo‐controlled, dose escalation trial of the anti‐herpes simplex virus monoclonal antibody HDIT101 in healthy volunteers by Blank, Antje, Hohmann, Nicolas, Dettmer, Marlen, Manka‐Stuhlik, Anette, Mikus, Gerd, Stoll, Felicitas, Stützle‐Schnetz, Marlies, Thomas, Daniel, Exner, Evelyn, Schmitt‐Bormann, Beate, Schaller, Torsten, Laage, Rico, Schönborn‐Kellenberger, Oliver, Arndt, Michaela, Haefeli, Walter E., Krauss, Jürgen

“…HDIT101 is a first‐in‐class humanized monoclonal antibody recognizing a conserved epitope in glycoprotein B, a target present on the surface of herpes simplex…”
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Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease by FRANK, Tobias, KLINKER, Florian, BÄHR, Mathias, WEISHAUPT, Jochen H, FALKENBURGER, Bjorn H, LAAGE, Rico, LÜHDER, Fred, GÖRICKE, Bettina, SCHNEIDER, Armin, NEURATH, Hartmud, DESEL, Herbert, LIEBETANZ, David

“…Recent proof-of-principle data showed that the haematopoietic growth factor granulocyte colony-stimulating factor (filgrastim) mediates neuroprotection in…”
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Granulocyte-colony stimulating factor (G-CSF) in stroke patients with concomitant vascular disease--a randomized controlled trial by Floel, Agnes, Warnecke, Tobias, Duning, Thomas, Lating, Yvonne, Uhlenbrock, Jan, Schneider, Armin, Vogt, Gerhard, Laage, Rico, Koch, Winfried, Knecht, Stefan, Schäbitz, Wolf-Rüdiger

“…G-CSF has been shown in animal models of stroke to promote functional and structural regeneration of the central nervous system. It thus might present a…”
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hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury by Pitzer, Claudia, Klussmann, Stefan, Krüger, Carola, Letellier, Elisabeth, Plaas, Christian, Dittgen, Tanjew, Kirsch, Friederike, Stieltjes, Bram, Weber, Daniela, Laage, Rico, Martin-Villalba, Ana, Schneider, Armin

“…J. Neurochem. (2010) 113, 930-942. Granulocyte-colony stimulating factor (G-CSF) is a potent hematopoietic factor that drives differentiation of neutrophilic…”
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The hematopoietic factor GM-CSF (granulocyte-macrophage colony-stimulating factor) promotes neuronal differentiation of adult neural stem cells in vitro by Krüger, Carola, Laage, Rico, Pitzer, Claudia, Schäbitz, Wolf-Rüdiger, Schneider, Armin

“…Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and…”
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Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease by Meuer, Katrin, Pitzer, Claudia, Teismann, Peter, Krüger, Carola, Göricke, Bettina, Laage, Rico, Lingor, Paul, Peters, Kerstin, Schlachetzki, Johannes C.M, Kobayashi, Kazuto, Dietz, Gunnar P.H, Weber, Daniela, Ferger, Boris, Schäbitz, Wolf-Rüdiger, Bach, Alfred, Schulz, Jörg B, Bähr, Mathias, Schneider, Armin, Weishaupt, Jochen H

“…We have recently shown that the hematopoietic Granulocyte-Colony Stimulating Factor (G-CSF) is neuroprotective in rodent stroke models, and that this action…”
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An extended window of opportunity for G-CSF treatment in cerebral ischemia by Schneider, Armin, Wysocki, Rainer, Pitzer, Claudia, Krüger, Carola, Laage, Rico, Schwab, Stefan, Bach, Alfred, Schäbitz, Wolf-Rüdiger

“…Granulocyte-colony stimulating factor (G-CSF) is known as a powerful regulator of white blood cell proliferation and differentiation in mammals. We, and…”
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A Heptad Motif of Leucine Residues Found in Membrane Proteins Can Drive Self-assembly of Artificial Transmembrane Segments by Gurezka, R, Laage, R, Brosig, B, Langosch, D

“…Specific interactions between α-helical transmembrane segments are important for folding and/or oligomerization of membrane proteins. Previously, we have…”
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A Cycle of Vam7p Release from and PtdIns 3-P-Dependent Rebinding to the Yeast Vacuole Is Required for Homotypic Vacuole Fusion by Boeddinghaus, Christine, Merz, Alexey J., Laage, Ricco, Ungermann, Christian

“…Vacuole fusion requires a coordinated cascade of priming, docking, and fusion. SNARE proteins have been implicated in the fusion itself, although their precise…”
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Strategies for Prokaryotic Expression of Eukaryotic Membrane Proteins by Laage, Rico, Langosch, Dieter

“…High‐level heterologous expression of integral membrane proteins at full‐length is a useful tool for their structural and functional characterization. Here,…”
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Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4 by Schneider, Armin, Laage, Rico, Von Ahsen, Oliver, Fischer, Achim, Rossner, Moritz, Scheek, Sigrid, Grünewald, Sylvia, Kuner, Rohini, Weber, Daniela, Krüger, Carola, Klaussner, Bettina, Götz, Bernhard, Hiemisch, Holger, Newrzella, Dieter, Martin‐Villalba, Ana, Bach, Alfred, Schwaninger, Markus

“…Cerebral ischaemia induces transcriptional changes in a number of pathophysiologically important genes. Here we have systematically studied gene expression…”
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Initial Lesion Volume Is an Independent Predictor of Clinical Stroke Outcome at Day 90: An Analysis of the Virtual International Stroke Trials Archive (VISTA) Database by Vogt, Gerhard, Laage, Rico, Shuaib, Ashfaq, Schneider, Armin

“…Age and National Institutes of Health Stroke Scale early after stroke onset have been identified as important determinants of final stroke outcome. We analyzed…”
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A Conserved Membrane-spanning Amino Acid Motif Drives Homomeric and Supports Heteromeric Assembly of Presynaptic SNARE Proteins by Laage, Rico, Rohde, Jan, Brosig, Bettina, Langosch, Dieter

“…Assembly of the SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 to binary and ternary complexes is important for docking and/or fusion of presynaptic…”
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Imaging Markers of Brain Frailty and Outcome in Patients With Acute Ischemic Stroke by Bu, Ning, Khlif, Mohamed Salah, Lemmens, Robin, Wouters, Anke, Fiebach, Jochen B., Chamorro, Angel, Ringelstein, E. Bernd, Norrving, Bo, Laage, Rico, Grond, Martin, Wilms, Guido, Brodtmann, Amy, Thijs, Vincent

“…Functional outcome after stroke may be related to preexisting brain health. Several imaging markers of brain frailty have been described including brain…”
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Association Between Time From Stroke Onset and Fluid-Attenuated Inversion Recovery Lesion Intensity Is Modified by Status of Collateral Circulation by Wouters, Anke, Dupont, Patrick, Christensen, Soren, Norrving, Bo, Laage, Rico, Thomalla, Götz, Albers, Greg, Thijs, Vincent, Lemmens, Robin

“…BACKGROUND AND PURPOSE—In patients with acute stroke, the intensity of a fluid-attenuated inversion recovery (FLAIR) lesion in the region of diffusion…”
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