Search Results - "L.V. Costa-Lotufo"

Genotoxic effects of aluminum chloride in cultured human lymphocytes treated in different phases of cell cycle by Lima, P.D.L., Leite, D.S., Vasconcellos, M.C., Cavalcanti, B.C., Santos, R.A., Costa-Lotufo, L.V., Pessoa, C., Moraes, M.O., Burbano, R.R.

“…Aluminum (Al) is the most abundant metal and the third common chemical element on earth. It is known that Al is toxic, especially its trivalent form (Al 3+),…”
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IDENTIFICATION AND EVALUATION OF POTENTIAL STATHMIN 1 INHIBITORS IN ACUTE LEUKEMIA CELLULAR MODELS by J.A.E.G. Carlos, K. Lima, L.V. Costa-Lotufo, A. Leitão, J.A. Machado-Neto

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ANÁLOGOS DE INIBIDORES DE FENIL-HIDROXAMATO REDUZEM A ATIVIDADE DE HDAC E APRESENTAM EFEITOS ANTIPROLIFERATIVOS EM LEUCEMIA LINFOBLÁSTICA AGUDA by L.C. Almeida, M.T. Tavares, R. Parise-Filho, J.A. Machado-Neto, L.V. Costa-Lotufo

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In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper by Bezerra, D P, Castro, F O, Alves, A P N N, Pessoa, C, Moraes, M O, Silveira, E R, Lima, M A S, Elmiro, F J M, Costa-Lotufo, L V

“…Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} and piperine…”
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EMBELINA POTENCIALIZA A APOPTOSE INDUZIDA POR VENETOCLAX EM LINHAGEM CELULAR DE LEUCEMIA MIELODE AGUDA KASUMI 1 by C.S.M. Reis-Silva, P.C. Branco, F.L. Silva, P.R. Moreno, K. Lima, J.A. Machado-Neto, L.V. Costa-Lotufo

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INIBIÇÃO FARMACOLÓGICA DE EZRINA REDUZ A VIABILIDADE, A CLONOGENICIDADE E A ATIVAÇÃO DA VIA PI3K/AKT/MTOR EM MODELOS CELULARES DE LEUCEMIA MIELOIDE AGUDA by J.C.L. Silva, J.L. Coelho-Silva, K. Lima, H.P. Vicari, L.V. Costa-Lotufo, F. Traina, J.A. Machado-Neto

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CARACTERIZAÇÃO CELULAR E MOLECULAR DA ATIVIDADE ANTILEUCÊMICA DE UM NOVO CICLOPENTA[B]INDOL SINTÉTICO EM MODELOS DE LEUCEMIA PROMIELOCÍTICA AGUDA SENSÍVEIS E RESISTENTES AO ATRA by H.P. Vicari, F. Coelho, K. Lima, R.C. Gomes, J.C.L. Silva, D.C. Gomes, M.T.R. Junior, A.S.B. Oliveira, L.V. Costa-Lotufo, J.A. Machado-Neto

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OBATOCLAX REDUCES CELL VIABILITY OF ACUTE MYELOID LEUKEMIA CELLS INDEPENDENTLY OF THEIR SENSITIVITY TO VENETOCLAX by K. Lima, H.P. Vicari, C. Hirakata, J.A.E.G. Carlos, J.C.L. Silva, F. Traina, L.L.F. Pontes, L.V. Costa-Lotufo, E.M. Rego, J.A. Machado-Neto

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The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea by da Silva, D.B., Tulli, E.C.O., Militão, G.C.G., Costa-Lotufo, L.V., Pessoa, C., de Moraes, M.O., Albuquerque, S., de Siqueira, J.M.

“…The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following…”
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Genotoxicity evaluation of kaurenoic acid, a bioactive diterpenoid present in Copaiba oil by Cavalcanti, B.C., Costa-lotufo, L.V., Moraes, M.O., Burbano, R.R., Silveira, E.R., Cunha, K.M.A., Rao, V.S.N., Moura, D.J., Rosa, R.M., Henriques, J.A.P., Pessoa, C.

“…Copaiba oil extracted from the Amazon traditional medicinal plant Copaifera langsdorffii is rich in kaurenoic acid (ent-kaur-16-en-19-oic acid), a diterpene…”
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Structural, thermal, electronic, vibrational, magnetic, and cytotoxic properties of chloro(glycinato-N,O)(1,10-phenanthroline-N,N′)‑copper(II) trihydrate coordination complex by de Oliveira Neto, J.G., Filho, J.G. Silva, Bittar, E.M., Silva, L.M., de Sousa, F.F., Domingos, H.V., Costa-Lotufo, L.V., Reis, A.S., dos Santos, A.O.

“…Chloro(glycinato-N,O)(1,10-phenanthroline-N,N′)‑copper(II) trihydrate complex was synthesized through the slow evaporation method. The crystal's structural,…”
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Toxicity to sea urchin egg development of the quinone fraction obtained from Auxemma oncocalyx by Costa-Lotufo, L V, Ferreira, M A D, Lemos, T L G, Pessoa, O D L, Viana, G S B, Cunha, G M A

“…Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the…”
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Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia) by Kerchove, C M, Markus, R P, Freitas, J C, Costa-Lotufo, L V

“…Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable…”
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In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells by Moura, A.F., Lima, K.S.B., Sousa, T.S., Marinho-Filho, J.D.B., Pessoa, C., Silveira, E.R., Pessoa, O.D.L., Costa-Lotufo, L.V., Moraes, M.O., Araújo, A.J.

“…The use of natural products in therapeutics has been growing over the years. Lignans are compounds with large pharmaceutical use, which has aroused interest in…”
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Studies of the anticancer potential of plants used in Bangladeshi folk medicine by Costa-Lotufo, Letícia Veras, Khan, Mahmud Tareq Hassan, Ather, Arjumand, Wilke, Diego Veras, Jimenez, Paula Christine, Pessoa, Cláudia, de Moraes, Maria Elisabete Amaral, de Moraes, Manoel Odorico

“…The present study evaluated the anticancer potential of 11 plants used in Bangladeshi folk medicine. The extracts were tested for cytotoxicity using the brine…”
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Growth inhibitory effects of 3′-nitro-3-phenylamino nor-beta-lapachone against HL-60: A redox-dependent mechanism by Araújo, A.J., de Souza, A.A., da Silva Júnior, E.N., Marinho-Filho, J.D.B., de Moura, M.A.B.F., Rocha, D.D., Vasconcellos, M.C., Costa, C.O., Pessoa, C., de Moraes, M.O., Ferreira, V.F., de Abreu, F.C., Pinto, A.V., Montenegro, R.C., Costa-Lotufo, L.V., Goulart, M.O.F.

“…► 3′-Nitro-3-phenylamino nor-β-lapachone (QPhNO2) is more active than its precursor. ► QPhNO2 suffers auto-oxidation and is DNA-reactive. ► QPhNO2 induces…”
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Structure–mutagenicity relationship of kaurenoic acid from Xylopia sericeae (Annonaceae) by Cavalcanti, B.C., Ferreira, J.R.O., Moura, D.J., Rosa, R.M., Furtado, G.V., Burbano, R.R., Silveira, E.R., Lima, M.A.S., Camara, C.A.G., Saffi, J., Henriques, J.A.P., Rao, V.S.N., Costa-Lotufo, L.V., Moraes, M.O., Pessoa, C.

“…Kaurane diterpenes are considered important compounds in the development of new highly effective anticancer chemotherapeutic agents. Genotoxic effects of…”
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The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin by Costa-Lotufo, L.V., Cunha, G.M.A., Farias, P.A.M., Viana, G.S.B., Cunha, K.M.A., Pessoa, C., Moraes, M.O., Silveira, E.R., Gramosa, N.V., Rao, V.S.N.

“…In this work, we studied the effects of kaurenoic acid, a diterpene isolated from the oleo-resin of Copaifera langsdorffii in developing sea urchin (…”
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Genotoxic and cytotoxic effects of manganese chloride in cultured human lymphocytes treated in different phases of cell cycle by Lima, P.D.L., Vasconcellos, M.C., Bahia, M.O., Montenegro, R.C., Pessoa, C.O., Costa-Lotufo, L.V., Moraes, M.O., Burbano, R.R.

“…Manganese (Mn) has a natural occurrence and is necessary during the initial periods of the development. However, in high concentrations, Mn can be related to…”
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Cytotoxic Flavonoids from Platymiscium floribundum by Falcão, Maria José C, Pouliquem, Yvone Brígido M, Lima, Mary Anne S, Gramosa, Nilce Viana, Costa-Lotufo, Letícia V, Militão, Gardênia Carmen G, Pessoa, Cláudia, Odorico de Moraes, Manoel, Silveira, Edilberto R

“…Two new isoflavonoids, 7-hydroxy-6,4‘-dimethoxy-isoflavonequinone (1) and 2‘-hydroxy-6,4‘,6‘ ‘,4‘ ‘‘-tetramethoxy-[7-O-7‘ ‘]-bisisoflavone (2), and seven other…”
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