PREVALENCE OF POLYMORPHIC VARIANTS OF GENES HLA SYSTEM IN HEALTHY DONORS OF KRASNODAR REGION

Polymorphism studies major histocompatibility complex human (HLA-system) in the world, held from mid-60s, when serotyping methods revealed that in different populations are determined by different sets of options HLA-antigens. Genes of class II HLA-system determines a significant portion of the gene...

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Bibliographic Details
Published in:	Kubanskiĭ nauchnyĭ medit︠s︡inskiĭ vestnik no. 7; pp. 129 - 132
Main Authors:	A. I. Tlif, E. I. Kondratyeva, N. V. Tarasenko, М. Ya. Zobenko, A. A. T. Kodenev, L. R. Gysaryk
Format:	Journal Article
Language:	Russian
Published:	Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 01-07-2017
Subjects:	alleles antigens hla genes of the system polymorphism population control
Online Access:	Get full text
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Summary:	Polymorphism studies major histocompatibility complex human (HLA-system) in the world, held from mid-60s, when serotyping methods revealed that in different populations are determined by different sets of options HLA-antigens. Genes of class II HLA-system determines a significant portion of the genetic predisposition to the development of the majority of diseases associated with the immune system. In the analysis of allelic polymorphism of the genes HLA-DQA1, HLA-DRB1, HLA-DRB1 found that among healthy donors Krasnodar in absolute terms more common alleles DQA10501, DQA1 0201, DQB1* 0301, DQB1* 0601/8, DRB1 01 DRB1 15. Compare the population do not have significant differences and can be used as control groups in studies aimed at understanding the contribution of genes HLA II class for the development of diseases in the russian group. The results indicate the presence in the population of the Krasnodar territory is not only the «classical» alleles, but found only in Russia and in the region.
ISSN:	1608-6228 2541-9544
DOI:	10.25207/1608-6228-2014-7-129-132