Search Results - "L. Morse, David"

The Damaging Effect of Passenger Mutations on Cancer Progression by McFarland, Christopher D, Yaglom, Julia A, Wojtkowiak, Jonathan W, Scott, Jacob G, Morse, David L, Sherman, Michael Y, Mirny, Leonid A

“…Genomic instability and high mutation rates cause cancer to acquire numerous mutations and chromosomal alterations during its somatic evolution; most are…”
Get full text

Development of Targeted Alpha Particle Therapy for Solid Tumors by Tafreshi, Narges K, Doligalski, Michael L, Tichacek, Christopher J, Pandya, Darpan N, Budzevich, Mikalai M, El-Haddad, Ghassan, Khushalani, Nikhil I, Moros, Eduardo G, McLaughlin, Mark L, Wadas, Thaddeus J, Morse, David L

“…Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-particles (cytotoxic payload) to tumors by chelation to monoclonal…”
Get full text

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases by ROBEY, Ian F, BAGGETT, Brenda K, GILLIES, Robert J, KIRKPATRICK, Nathaniel D, ROE, Denise J, DOSESCU, Julie, SLOANE, Bonnie F, IBRAHIM HASHIM, Arig, MORSE, David L, RAGHUNAND, Natarajan, GATENBY, Robert A

“…The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor…”
Get full text

Welcome to the Glass Age by Morse, David L., Evenson, Jeffrey W.

“…Glass is one of the world's most transformative materials. Featuring tremendous versatility and distinctive technical capabilities, glass has been responsible…”
Get full text

Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases by Tafreshi, Narges K, Lloyd, Mark C, Bui, Marilyn M, Gillies, Robert J, Morse, David L

“…Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. It is constitutively…”
Get more information

A Corning perspective on the future of technical glass in our evolving world by Kohli, Jeffrey T., Hubert, Mathieu, Youngman, Randall E., Morse, David L.

“…Glass is a material with a rich history and a bright future. Due to its outstanding properties and its versatility, it is a key material in many applications…”
Get full text

Photoacoustic tomography and fluorescence molecular tomography: A comparative study based on indocyanine green by Wang, Bo, Zhao, Qing, Barkey, Natalie M., Morse, David L., Jiang, Huabei

“…Purpose: Both photoacoustic tomography (PAT) and fluorescence molecular tomography (FMT) can be used for molecular imaging when contrast agents are…”
Get full text

A Monte Carlo Method for Determining the Response Relationship between Two Commonly Used Detectors to Indirectly Measure Alpha Particle Radiation Activity by Tichacek, Christopher J, Budzevich, Mikalai M, Wadas, Thaddeus J, Morse, David L, Moros, Eduardo G

“…Using targeted ligands to deliver alpha-emitting radionuclides directly to tumor cells has become a promising therapeutic strategy. To calculate the radiation…”
Get full text

Analysis techniques for coherent airborne radar sounding: Application to West Antarctic ice streams by Peters, Matthew E., Blankenship, Donald D., Morse, David L.

“…Analysis of coherent radar sounding echoes from polar ice sheets can provide information suitable for classifying the subglacial environment. Echoes from a…”
Get full text

Heterobivalent ligands target cell-surface receptor combinations in vivo by Xu, Liping, Josan, Jatinder S., Vagner, Josef, Caplan, Michael R., Hruby, Victor J., Mash, Eugene A., Lynch, Ronald M., Morse, David L., Gillies, Robert J.

“…A challenge in tumor targeting is to deliver payloads to cancers while sparing normal tissues. A limited number of antibodies appear to meet this challenge as…”
Get full text

Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells by Morse, David L, Gray, Heather, Payne, Claire M, Gillies, Robert J

“…Apoptosis has long been considered to be the prevailing mechanism of cell death in response to chemotherapy. Currently, a more heterogeneous model of tumor…”
Get full text

Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells by Huynh, Amanda Shanks, Abrahams, Dominique F, Torres, Monica S, Baldwin, Margaret K, Gillies, Robert J, Morse, David L

“…Mice have been employed as models of cancer for over a century, providing significant advances in our understanding of this multifaceted family of diseases. In…”
Get full text

Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes by TAFRESHI, Narges K, BUI, Marilyn M, GILLIES, Robert J, MORSE, David L, BISHOP, Kellsey, LLOYD, Mark C, ENKEMANN, Steven A, LOPEZ, Alexis S, ABRAHAMS, Dominique, CARTER, Bradford W, VAGNER, Josef, GOBMYER, Stephen R

“…To develop targeted molecular imaging probes for the noninvasive detection of breast cancer lymph node metastasis. Six cell surface or secreted markers were…”
Get full text

In vivo magnetic resonance spectroscopy in cancer by Gillies, Robert J, Morse, David L

“…Magnetic resonance spectroscopy (MRS) has been used for more than two decades to interrogate metabolite distributions in living cells and tissues. Techniques…”
Get full text

Targeting Ligand Specificity Linked to Tumor Tissue Topological Heterogeneity via Single-Cell Micro-Pharmacological Modeling by Karolak, Aleksandra, Estrella, Veronica C., Huynh, Amanda S., Chen, Tingan, Vagner, Josef, Morse, David L., Rejniak, Katarzyna A.

“…Targeted therapy has held promise to be a successful anticancer treatment due to its specificity towards tumor cells that express the target receptors…”
Get full text

Diffusion MRI and novel texture analysis in osteosarcoma xenotransplants predicts response to anti-checkpoint therapy by Foroutan, Parastou, Kreahling, Jenny M, Morse, David L, Grove, Olya, Lloyd, Mark C, Reed, Damon, Raghavan, Meera, Altiok, Soner, Martinez, Gary V, Gillies, Robert J

“…Combinations of targeted drugs have been employed to treat sarcomas, however, response rates have not improved notably, therefore emphasizing the need for…”
Get full text

The role of toll-like receptors in colorectal cancer progression: evidence for epithelial to leucocytic transition by Luddy, Kimberly A, Robertson-Tessi, Mark, Tafreshi, Narges K, Soliman, Hatem, Morse, David L

“…Toll-like receptors (TLRs) are expressed by immune cells, intestinal epithelium, and tumor cells. In the homeostatic setting, they help to regulate control…”
Get full text

Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents by Martinez, Gary V., Zhang, Xiaomeng, García-Martín, María L., Morse, David L., Woods, Mark, Sherry, A. Dean, Gillies, Robert J.

“…The extracellular pH (pHe) of solid tumors is acidic, and there is evidence that an acidic pHe is related to invasiveness. Herein, we describe an MRI…”
Get full text

New boundary conditions for the West Antarctic ice sheet: Subglacial topography beneath Pine Island Glacier by Vaughan, David G., Corr, Hugh F. J., Ferraccioli, Fausto, Frearson, Nicholas, O'Hare, Aidan, Mach, Dieter, Holt, John W., Blankenship, Donald D., Morse, David L., Young, Duncan A.

“…Predictions about future changes in the Amundsen Sea sector of the West Antarctic ice sheet (WAIS) have been hampered by poorly known subglacial topography…”
Get full text

A Mammaglobin-A Targeting Agent for Noninvasive Detection of Breast Cancer Metastasis in Lymph Nodes by TAFRESHI, Narges K, ENKEMANN, Steven A, GILLIES, Robert J, MORSE, David L, BUI, Marilyn M, LLOYD, Mark C, ABRAHAMS, Dominique, HUYNH, Amanda S, KIM, Jongphil, GROBMYER, Stephen R, CARTER, W. Bradford, VAGNER, Josef

“…Pathologic axillary lymph node (ALN) status is an important prognostic factor for staging breast cancer. Currently, status is determined by histopathology…”
Get full text