Search Results - "L. Kennedy, Catherine"

STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation by Tye, Hazel, Kennedy, Catherine L., Najdovska, Meri, McLeod, Louise, McCormack, William, Hughes, Norman, Dev, Anouk, Sievert, William, Ooi, Chia Huey, Ishikawa, Tomo-o, Oshima, Hiroko, Bhathal, Prithi S., Parker, Andrew E., Oshima, Masanobu, Tan, Patrick, Jenkins, Brendan J.

“…Gastric cancer (GC) is associated with chronic inflammation; however, the molecular mechanisms promoting tumorigenesis remain ill defined. Using a GC mouse…”
Get full text

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism by Tang, Huibin, Inoki, Ken, Brooks, Susan V., Okazawa, Hideki, Lee, Myung, Wang, Junying, Kim, Michael, Kennedy, Catherine L., Macpherson, Peter C. D., Ji, Xuhuai, Van Roekel, Sabrina, Fraga, Danielle A., Wang, Kun, Zhu, Jinguo, Wang, Yoyo, Sharp, Zelton D., Miller, Richard A., Rando, Thomas A., Goldman, Daniel, Guan, Kun‐Liang, Shrager, Joseph B.

“…Aging leads to skeletal muscle atrophy (i.e., sarcopenia), and muscle fiber loss is a critical component of this process. The mechanisms underlying these…”
Get full text

Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation by Tang, Huibin, L. Kennedy, Catherine, Lee, Myung, Gao, Yang, Xia, Hui, Olguin, Francesca, Fraga, Danielle A., Ayers, Kelsey, Choi, Sehoon, Kim, Michael, Tehrani, Amir, Sowb, Yasser A., Rando, Thomas A., Shrager, Joseph B.

“…Prolonged use of mechanical ventilation (MV) leads to atrophy and dysfunction of the major inspiratory muscle, the diaphragm, contributing to ventilator…”
Get full text

Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum by Kennedy, Catherine L, Smith, Danielle J, Lyras, Dena, Chakravorty, Anjana, Rood, Julian I

“…Programmed necrosis is a mechanism of cell death that has been described for neuronal excitotoxicity and ischemia/reperfusion injury, but has not been…”
Get full text

Influential factors when considering reconstruction and post-operative outcomes: A survey of microtia patients and parents by Leto Barone, Angelo A., Harris, Thomas G.W., Schroeder, Michael J., Kennedy, Catherine L., Cooney, Carisa M., Ranganathan, Kavitha L., Steinberg, Jordan P., Redett, Richard J.

Get full text

Molecular and cellular basis of microvascular perfusion deficits induced by Clostridium perfringens and Clostridium septicum by Hickey, Michael J, Kwan, Rain Y Q, Awad, Milena M, Kennedy, Catherine L, Young, Lauren F, Hall, Pam, Cordner, Leanne M, Lyras, Dena, Emmins, John J, Rood, Julian I

“…Reduced tissue perfusion leading to tissue ischemia is a central component of the pathogenesis of myonecrosis caused by Clostridium perfringens. The C…”
Get full text

Pore-Forming Activity of Alpha-Toxin Is Essential for Clostridium septicum-Mediated Myonecrosis by Kennedy, Catherine L, Lyras, Dena, Cordner, Leanne M, Melton-Witt, Jody, Emmins, John J, Tweten, Rodney K, Rood, Julian I

“…Clostridium septicum alpha-toxin is a β-barrel pore-forming cytolysin that is functionally similar to aerolysin. Residues important in receptor binding,…”
Get full text

The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17 by Kennedy, Catherine L, Najdovska, Meri, Jones, Gareth W, McLeod, Louise, Hughes, Norman R, Allison, Cody, Huey Ooi, Chia, Tan, Patrick, Ferrero, Richard L, Jones, Simon A, Dev, Anouk, Sievert, William, Bhathal, Prithi S, Jenkins, Brendan J

“…Chronic activation of the gastric mucosal adaptive immune response is a characteristic trait of gastric cancer. It has recently emerged that a new class of T…”
Get full text

NanI and NanJ Sialidases of Clostridium perfringens Are Not Essential for Virulence by Chiarezza, Martina, Lyras, Dena, Pidot, Sacha J, Flores-Díaz, Marietta, Awad, Milena M, Kennedy, Catherine L, Cordner, Leanne M, Phumoonna, Tongted, Poon, Rachael, Hughes, Meredith L, Emmins, John J, Alape-Girón, Alberto, Rood, Julian I

“…The essential toxin in Clostridium perfringens-mediated gas gangrene or clostridial myonecrosis is alpha-toxin, although other toxins and extracellular enzymes…”
Get full text

Metformin Protects Against Noise-Induced Hearing Loss in Male Mice by Kennedy, Catherine L., Shuster, Benjamin, Amanipour, Reza, Milon, Beatrice, Patel, Priya, Elkon, Ran, Hertzano, Ronna

“…Metformin treatment will protect mice from noise-induced hearing loss (NIHL).HYPOTHESISMetformin treatment will protect mice from noise-induced hearing loss…”
Get full text

A type III effector antagonizes death receptor signalling during bacterial gut infection by Pearson, Jaclyn S., Giogha, Cristina, Ong, Sze Ying, Kennedy, Catherine L., Kelly, Michelle, Robinson, Keith S., Lung, Tania Wong Fok, Mansell, Ashley, Riedmaier, Patrice, Oates, Clare V. L., Zaid, Ali, Mühlen, Sabrina, Crepin, Valerie F., Marches, Olivier, Ang, Ching-Seng, Williamson, Nicholas A., O’Reilly, Lorraine A., Bankovacki, Aleksandra, Nachbur, Ueli, Infusini, Giuseppe, Webb, Andrew I., Silke, John, Strasser, Andreas, Frankel, Gad, Hartland, Elizabeth L.

“…Colonizing enteric bacteria are shown to inhibit the antimicrobial process of host cell apoptosis through the action of NleB1, a type III secretion system…”
Get full text

Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer by Yu, Liang, Wu, Di, Gao, Hugh, Balic, Jesse J, Tsykin, Anna, Han, Tae-Su, Liu, You Dong, Kennedy, Catherine L, Li, Ji Kun, Mao, Jie Qi, Tan, Patrick, Oshima, Masanobu, Goodall, Gregory J, Jenkins, Brendan J

“…The majority of gastric cancer patients are diagnosed with late-stage disease, for which distinct molecular subtypes have been identified that are potentially…”
Get full text

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD) by Scott, Nichollas E., Giogha, Cristina, Pollock, Georgina L., Kennedy, Catherine L., Webb, Andrew I., Williamson, Nicholas A., Pearson, Jaclyn S., Hartland, Elizabeth L.

“…The inhibition of host innate immunity pathways is essential for the persistence of attaching and effacing pathogens such as enteropathogenic Escherichia coli…”
Get full text

Citrobacter rodentium Infection Model for the Analysis of Bacterial Pathogenesis and Mucosal Immunology by Kennedy, Catherine L, Hartland, Elizabeth L

“…Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia,…”
Get more information

Prospective validation of a brief questionnaire for predicting the severity of pediatric obstructive sleep apnea by Kennedy, Catherine L., Onwumbiko, Bella E., Blake, Jasmine, Pereira, Kevin D., Isaiah, Amal

“…Pediatric obstructive sleep apnea (OSA) is diagnosed and stratified by polysomnography. However, due to cost and inaccessibility, up to 90% of children undergo…”
Get full text

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production by Nachbur, Ueli, Stafford, Che A., Bankovacki, Aleksandra, Zhan, Yifan, Lindqvist, Lisa M., Fiil, Berthe K., Khakham, Yelena, Ko, Hyun-Ja, Sandow, Jarrod J., Falk, Hendrik, Holien, Jessica K., Chau, Diep, Hildebrand, Joanne, Vince, James E., Sharp, Phillip P., Webb, Andrew I., Jackman, Katherine A., Mühlen, Sabrina, Kennedy, Catherine L., Lowes, Kym N., Murphy, James M., Gyrd-Hansen, Mads, Parker, Michael W., Hartland, Elizabeth L., Lew, Andrew M., Huang, David C. S., Lessene, Guillaume, Silke, John

“…Intracellular nucleotide binding and oligomerization domain (NOD) receptors recognize antigens including bacterial peptidoglycans and initiate immune responses…”
Get full text

Reply to authors: “Influential factors when considering reconstruction and post-operative outcomes: A survey of microtia patients and parents” by Leto Barone, Angelo A., Harris, Thomas G.W., Schroeder, Michael J., Kennedy, Catherine L., Cooney, Carisa M., Ranganathan, Kavitha L., Steinberg, Jordan P., Redett III, Richard J.

Get full text

Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis by Jones, Gareth W, McLeod, Louise, Kennedy, Catherine L, Bozinovski, Steven, Najdovska, Meri, Jenkins, Brendan J

“…Abstract Objective Interleukin (IL)-6 is a key modulator of the acute phase response (APR), and while both are implicated in atherosclerosis, the pathological…”
Get full text

Fas regulates neutrophil lifespan during viral and bacterial infection by O’Donnell, Joanne A., Kennedy, Catherine L., Pellegrini, Marc, Nowell, Cameron J., Zhang, Jian‐Guo, O’Reilly, Lorraine A., Cengia, Louise, Dias, Stuart, Masters, Seth L., Hartland, Elizabeth L., Roberts, Andrew W., Gerlic, Motti, Croker, Ben A.

“…Neutrophils use Toll‐like receptor and IL‐18 signaling to reprogram Fas‐induced death. The regulation of neutrophil lifespan is critical for a circumscribed…”
Get full text

The α‐toxin of Clostridium septicum is essential for virulence by Kennedy, Catherine L., Krejany, Efrosinia O., Young, Lauren F., O'Connor, Jennifer R., Awad, Milena M., Boyd, Richard L., Emmins, John J., Lyras, Dena, Rood, Julian I.

“…Summary Clostridium septicum is the causative agent of spontaneous gas gangrene or atraumatic myonecrosis, a sudden and frequently fatal infection that is…”
Get full text