Search Results - "L. Holliman, Christopher"

A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker by Luo, Lina, Ramanathan, Ragu, Horlbogen, Lauren, Mathialagan, Sumathy, Costales, Chester, Vourvahis, Manoli, Holliman, Christopher L, Rodrigues, A. David

“…There is a growing interest in using endogenous compounds as drug transporter biomarkers to facilitate drug–drug interaction (DDI) risk assessment in early…”
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A multiplex HRMS assay for quantifying selected human plasma bile acids as candidate OATP biomarkers by Rago, Brian, Tierney, Brendan, Rodrigues, A. David, L. Holliman, Christopher, Ramanathan, Ragu

“…Selected bile acids (BAs) in plasma have been proposed as endogenous probes for assessing drug-drug interactions involving hepatic drug transporters such as…”
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A highly selective and sensitive LC-MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers by Ramanathan, Ragu, King-Ahmad, Amanda J, Holliman, Christopher L, Rodrigues, A David

“…Coproporphyrin-I (CP-I) and coproporphyrin-III (CP-III) in plasma and urine have been proposed as biomarkers for assessing drug-drug interactions involving…”
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Inception and development of a LC-MS/MS assay for the multiplexed quantitation of nine human drug transporter biomarkers by Kadar, Eugene P, Holliman, Christopher L, Vourvahis, Manoli, Rodrigues, A David

“…It has become common practice to assess solute carrier transporter (SLC)-mediated drug-drug interactions (DDIs) by quantitating various individual endogenous…”
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Bioanalysis of Targeted Nanoparticles in Monkey Plasma via LC-MS/MS by Song, Wei, Tweed, Joseph A, Visswanathan, Ravi, Saunders, James P, Gu, Zhenhua, Holliman, Christopher L

“…This work represents the first reporting of a comprehensive bioanalytical GLP methodology detailing the mass spectrometric quantitation of PF-05212384 dosed as…”
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Development of a sensitive LC-MS/MS assay to support human microdose study for an oral agonist of the GLP-1 receptor by Kadar, Eugene P, Eng, Heather, Kalgutkar, Amit S, Holliman, Christopher L, Steeno, Gregory S

“…The purpose of this work was to determine the feasibility of supporting a clinical microdose study for PF-06882961 (danuglipron), an oral small molecule…”
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Evaluation of OptiFlow™-MS/MS for bioanalysis of pharmaceutical drugs and metabolites by Barricklow, Jason, Tweed, Joseph, Holliman, Christopher L, Ramanathan, Ragu

“…Microflow tandem mass spectrometry-based methods have been proposed as options to improve sensitivity and selectivity while improving sample utility and…”
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Development and implementation of urinary transporter biomarkers to facilitate assessment of drug–drug interaction by Luo, Lina, Vourvahis, Manoli, Horlbogen, Lauren, Patel, Roshan, Mathialagan, Sumathy, Holliman, Christopher L, Rodrigues, A David

“…Novel urinary biomarker evaluation approaches to support inhibition assessment for renal transporters (e.g., OCT2, multidrug and toxin extrusion proteins…”
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LC–MS/MS Assay for N 1 -Methylnicotinamide in Humans, an Endogenous Probe for Renal Transporters by Luo, Lina, Kay, Jared, Zhang, Jenny, Holliman, Christopher L, Rodrigues, A David, Dowty, Martin, Banfield, Christopher, Ramanathan, Ragu

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Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion by Brown, Alan P., Courtney, Cynthia L., Criswell, Kay A., Holliman, Christopher L., Evering, Winston, Jessen, Bart A.

“…Purpose Cyclin-dependent kinases (CDKs) play a significant role in the control of cell-cycle progression and exhibit aberrant regulation in various neoplastic…”
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Accelerating drug development: methodology to support first-in-man pharmacokinetic studies by the use of drug candidate microdosing by McLean, Matthew A., Tam, Chi-Yan J., Baratta, Michael T., Holliman, Christopher L., Ings, Robert M., Galluppi, Gerald R.

“…Microdosing of experimental therapeutics in humans offers a number of benefits to the drug development process. Microdosing, conducted under an exploratory…”
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Precursors to Endohedral Metal Fullerene Complexes:  Synthesis and X-ray Structure of a Flexible Acetylenic Cyclophane C60H18 by Rubin, Yves, Parker, Timothy C, Khan, Saeed I, Holliman, Christopher L, McElvany, Stephen W

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The .beta.-distonic ion from the reaction of pyridine radical cation and ethene: a demonstration of high-pressure trapping in Fourier transform mass spectrometry by Yu, Sophia J, Holliman, Christopher L, Rempel, Don L, Gross, Michael L

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Recent advances in drug transporter sciences: highlights from the year 2020 by Chothe, Paresh P., Nakakariya, Masanori, Rotter, Charles J., Sandoval, Philip, Tohyama, Kimio

“…Drug Metabolism Reviews has an impressive track record of providing scientific reviews in the area of xenobiotic biotransformation over 47 years. It has…”
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LC-MS/MS assay for N by Luo, Lina, Kay, Jared, Zhang, Jenny, Holliman, Christopher L, Rodrigues, AD, Dowty, Martin, Banfield, Christopher, Ramanathan, Ragu

“…N -methylnicotinamide (1-NMN) has been proposed as a potential clinical biomarker to assess drug-drug interactions involving organic cation transporters (OCT2)…”
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Precursors to Endohedral Metal Fullerene Complexes:  Synthesis and X-ray Structure of a Flexible Acetylenic Cyclophane C 60 H 18 by Rubin, Yves, Parker, Timothy C., Khan, Saeed I., Holliman, Christopher L., McElvany, Stephen W.

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