Search Results - "L. Berg, Ellen"

Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches by Lee, Jonathan A, Berg, Ellen L

“…Innovation and new molecular entity production by the pharmaceutical industry has been below expectations. Surprisingly, more first-in-class small-molecule…”
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Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery by L. Berg, Ellen, Hsu, Yu-Chih, Lee, Jonathan A.

“…There is renewed interest in phenotypic approaches to drug discovery, using cell-based assays to select new drugs, with the goal of improving pharmaceutical…”
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Phenotypic chemical biology for predicting safety and efficacy by Berg, Ellen L.

“…[Display omitted] •Improved clinical relevance of screening assays increases the quality of new drugs.•Modern drug discovery combines phenotypic and…”
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Human Cell-Based in vitro Phenotypic Profiling for Drug Safety-Related Attrition by Berg, Ellen L

“…Ensuring the safety of new drugs is critically important to regulators, pharmaceutical researchers and patients alike. Even so, unexpected toxicities still…”
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Building predictive models for mechanism-of-action classification from phenotypic assay data sets by Berg, Ellen L, Yang, Jian, Polokoff, Mark A

“…Compound mechanism-of-action information can be critical for drug development decisions but is often challenging for phenotypic drug discovery programs. One…”
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Bioassay protocol metadata annotation: Proposed standards adoption by Balakrishnan, Rama, Berg, Ellen L., Butler, Christopher C., Clark, Alex M., Denker, Sheryl P., Feierberg, Isabella, Harris, Jason, Ikeda, Timothy P., Jeschonek, Samantha, Makarov, Vladimir A., Southan, Christopher, Vanderwall, Dana, Winstanley, Peter

“…We present a standardized metadata template for assays used in pharmaceutical drug discovery research, according to the FAIR principles. We also describe the…”
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Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects by Berg, Ellen L, Polokoff, Mark A, O'Mahony, Alison, Nguyen, Dat, Li, Xitong

“…Here we describe a chemical biology approach for elucidating potential toxicity mechanisms for thrombosis-related side effects. This work takes advantage of a…”
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Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation by Melton, Andrew C, Melrose, Jennifer, Alajoki, Liisa, Privat, Sylvie, Cho, Hannah, Brown, Naomi, Plavec, Ana Marija, Nguyen, Dat, Johnston, Elijah D, Yang, Jian, Polokoff, Mark A, Plavec, Ivan, Berg, Ellen L, O'Mahony, Alison

“…Improper regulation of B cell responses leads to excessive production of antibodies and contributes to the development of autoimmune disease. T helper 17…”
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Systems biology in drug discovery and development by Berg, Ellen L.

“…The complexity of human biology makes it challenging to develop safe and effective new medicines. Systems biology omics-based efforts have led to an explosion…”
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Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes by Simms, Liam, Mason, Elizabeth, Berg, Ellen L., Yu, Fan, Rudd, Kathryn, Czekala, Lukasz, Trelles Sticken, Edgar, Brinster, Oleg, Wieczorek, Roman, Stevenson, Matthew, Walele, Tanvir

“…[Display omitted] A growing number of public health bodies, regulators and governments around the world consider electronic vapor products a lower risk…”
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Characterization of compound mechanisms and secondary activities by BioMAP analysis by Berg, Ellen L., Kunkel, Eric J., Hytopoulos, Evangelos, Plavec, Ivan

“…Unexpected drug activities account for many of the failures of new chemical entities in clinical trials. These activities can be target-dependent, resulting…”
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The activities of drug inactive ingredients on biological targets by Pottel, Joshua, Armstrong, Duncan, Zou, Ling, Fekete, Alexander, Huang, Xi-Ping, Torosyan, Hayarpi, Bednarczyk, Dallas, Whitebread, Steven, Bhhatarai, Barun, Liang, Guiqing, Jin, Hong, Ghaemi, S Nassir, Slocum, Samuel, Lukacs, Katalin V, Irwin, John J, Berg, Ellen L, Giacomini, Kathleen M, Roth, Bryan L, Shoichet, Brian K, Urban, Laszlo

“…Excipients, considered "inactive ingredients," are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their…”
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A Direct Comparison of Selectin-Mediated Transient, Adhesive Events Using High Temporal Resolution by Smith, McRae J., Berg, Ellen L., Lawrence, Michael B.

“…Leukocyte capture and rolling on the vascular endothelium is mediated principally by the selectin family of cell adhesion receptors. In a parallel plate flow…”
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Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms by Kleinstreuer, Nicole C, Yang, Jian, Berg, Ellen L, Knudsen, Thomas B, Richard, Ann M, Martin, Matthew T, Reif, David M, Judson, Richard S, Polokoff, Mark, Dix, David J, Kavlock, Robert J, Houck, Keith A

“…Results from screening hundreds of compounds on panels of primary human cells supports the use of such data for chemical safety testing. Addressing the safety…”
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An integrative biology approach for analysis of drug action in models of human vascular inflammation by Kunkel, Eric J., Dea, Marlene, Ebens, Allen, Hytopoulos, Evangelos, Melrose, Jennifer, Nguyen, Dat, Ota, Ken S., Plavec, Ivan, Wang, Yuker, Watson, Susan R., Butcher, Eugene C., Berg, Ellen L.

“…ABSTRACT Unexpected drug activities discovered during clinical testing establish the need for better characterization of compounds in human disease‐relevant…”
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Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators by Shah, Falgun, Stepan, Antonia F, O'Mahony, Alison, Velichko, Sharlene, Folias, Alexandra E, Houle, Christopher, Shaffer, Christopher L, Marcek, John, Whritenour, Jessica, Stanton, Robert, Berg, Ellen L

“…Cutaneous reactions represent one of the most common adverse drug effects observed in clinical trials leading to substantial compound attrition. Three negative…”
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Method for Analyzing Signaling Networks in Complex Cellular Systems by Plavec, Ivan, Sirenko, Oksana, Privat, Sylvie, Wang, Yuker, Dajee, Maya, Melrose, Jennifer, Nakao, Brian, Hytopoulos, Evangelos, Berg, Ellen L., Butcher, Eugene C.

“…Now that the human genome has been sequenced, the challenge of assigning function to human genes has become acute. Existing approaches using microarrays or…”
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Systems biology in drug discovery by Butcher, Eugene C, Berg, Ellen L, Kunkel, Eric J

“…The hope of the rapid translation of 'genes to drugs' has foundered on the reality that disease biology is complex, and that drug development must be driven by…”
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Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells by Houck, Keith A, Friedman, Katie Paul, Feshuk, Madison, Patlewicz, Grace, Smeltz, Marci, Clifton, M Scott, Wetmore, Barbara A, Velichko, Sharlene, Berenyi, Antal, Berg, Ellen L

“…A structurally diverse set of 147 per- and polyfluoroalkyl substances (PFAS) was screened in a panel of 12 human primary cell systems by measuring 148…”
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Phenotypic profiling for understanding mechanisms of cardiovascular adverse reactions by Berg, Ellen L., Velichko, Sharlene, Nguyen, Dat T., Melrose, Jennifer, O'Mahony, Alison

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