Search Results - "L Spires"

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease by Spires-Jones, Tara L., Hyman, Bradley T.

“…The collapse of neural networks important for memory and cognition, including death of neurons and degeneration of synapses, causes the debilitating dementia…”
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Interactions of pathological proteins in neurodegenerative diseases by Spires-Jones, Tara L., Attems, Johannes, Thal, Dietmar Rudolf

“…Neurodegenerative diseases such as Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTD), Lewy body disease (LBD), Parkinson’s disease (PD), and…”
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Potential neurobiological links between social isolation and Alzheimer's disease risk by Drinkwater, Elizabeth, Davies, Caitlin, Spires‐Jones, Tara L.

“…It is estimated that 40% of dementia cases could be prevented by modification of lifestyle factors that associate with disease risk. One of these potentially…”
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Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis by Henstridge, Christopher M., Hyman, Bradley T., Spires-Jones, Tara L.

“…The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests…”
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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease by de Calignon, Alix, Polydoro, Manuela, Suárez-Calvet, Marc, William, Christopher, Adamowicz, David H., Kopeikina, Kathy J., Pitstick, Rose, Sahara, Naruhiko, Ashe, Karen H., Carlson, George A., Spires-Jones, Tara L., Hyman, Bradley T.

“…Neurofibrillary tangles advance from layer II of the entorhinal cortex (EC-II) toward limbic and association cortices as Alzheimer's disease evolves. However,…”
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Pathological Tau Disrupts Ongoing Network Activity by Menkes-Caspi, Noa, Yamin, Hagar G., Kellner, Vered, Spires-Jones, Tara L., Cohen, Dana, Stern, Edward A.

“…Pathological tau leads to dementia and neurodegeneration in tauopathies, including Alzheimer’s disease. It has been shown to disrupt cellular and synaptic…”
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Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer's disease by Kurucu, Hatice, Colom‐Cadena, Martí, Davies, Caitlin, Wilkins, Lewis, King, Declan, Rose, Jamie, Tzioras, Makis, Tulloch, Jane H., Smith, Colin, Spires‐Jones, Tara L.

“…Background and purpose Synapse degeneration in Alzheimer's disease (AD) correlates strongly with cognitive decline. There is well‐established excitatory…”
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Synaptic pathology: a shared mechanism in neurological disease by Henstridge, Christopher M, Pickett, Eleanor, Spires-Jones, Tara L

“…Graphical abstract…”
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity by Izzo, Nicholas J, Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A, Arancio, Ottavio, Mach, Robert H, Craven, Rolf, Head, Elizabeth, LeVine, 3rd, Harry, Spires-Jones, Tara L, Catalano, Susan M

“…Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that…”
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Tau association with synaptic vesicles causes presynaptic dysfunction by Zhou, Lujia, McInnes, Joseph, Wierda, Keimpe, Holt, Matthew, Herrmann, Abigail G., Jackson, Rosemary J., Wang, Yu-Chun, Swerts, Jef, Beyens, Jelle, Miskiewicz, Katarzyna, Vilain, Sven, Dewachter, Ilse, Moechars, Diederik, De Strooper, Bart, Spires-Jones, Tara L., De Wit, Joris, Verstreken, Patrik

“…Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer’s disease. Under pathological conditions, Tau dissociates from axonal…”
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Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review by Saunders, Tyler S., Gadd, Danni A., Spires‐Jones, Tara L., King, Declan, Ritchie, Craig, Muniz‐Terrera, Graciela

“…A biomarker associated with cognition in neurodegenerative dementias would aid in the early detection of disease progression, complement clinical staging and…”
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Alzheimer's disease‐like neuropathology in three species of oceanic dolphin by Vacher, Marissa C., Durrant, Claire S., Rose, Jamie, Hall, Ailsa J., Spires‐Jones, Tara L., Gunn‐Moore, Frank, Dagleish, Mark P.

“…Alzheimer's disease (AD) is the most common neurodegenerative disease and the primary cause of disability and dependency among elderly humans worldwide. AD is…”
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Alzheimer's disease and related dementias: From risk factors to disease pathogenesis by Porsteinsson, Anton P., Rangaraju, Srikant, Spires‐Jones, Tara L., O'Banion, M. Kerry

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PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins by Corbett, Grant T., Wang, Zemin, Hong, Wei, Colom-Cadena, Marti, Rose, Jamie, Liao, Meichen, Asfaw, Adhana, Hall, Tia C., Ding, Lai, DeSousa, Alexandra, Frosch, Matthew P., Collinge, John, Harris, David A., Perkinton, Michael S., Spires-Jones, Tara L., Young-Pearse, Tracy L., Billinton, Andrew, Walsh, Dominic M.

“…Neurodegenerative diseases are an enormous public health problem, affecting tens of millions of people worldwide. Nearly all of these diseases are…”
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Tau pathophysiology in neurodegeneration: a tangled issue by Spires-Jones, Tara L, Stoothoff, William H, de Calignon, Alix, Jones, Phillip B, Hyman, Bradley T

“…Neurodegenerative tauopathies are marked by their common pathologic feature of aggregates formed of hyperphosphorylated tau protein, which are associated with…”
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Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging by Koffie, Robert M, Farrar, Christian T, Saidi, Laiq-Jan, William, Christopher M, Hyman, Bradley T, Spires-Jones, Tara L

“…Several imaging modalities are suitable for in vivo molecular neuroimaging, but the blood–brain barrier (BBB) limits their utility by preventing brain delivery…”
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Region-specific Dissociation of Neuronal Loss and Neurofibrillary Pathology in a Mouse Model of Tauopathy by Spires, Tara L., Orne, Jennifer D., SantaCruz, Karen, Pitstick, Rose, Carlson, George A., Ashe, Karen H., Hyman, Bradley T.

“…Neurofibrillary tangles form in a specific spatial and temporal pattern in Alzheimer's disease. Although tangle formation correlates with dementia and neuronal…”
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Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo by Kuchibhotla, Kishore V., Wegmann, Susanne, Kopeikina, Katherine J., Hawkes, Jonathan, Rudinskiy, Nikita, Andermann, Mark L., Spires-Jones, Tara L., Bacskai, Brian J., Hyman, Bradley T.

“…Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular amyloid-β plaques and intracellular aggregation of tau protein in…”
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Alzheimer's disease: synapses gone cold by Koffie, Robert M, Hyman, Bradley T, Spires-Jones, Tara L

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by insidious cognitive decline and memory dysfunction. Synapse loss is the…”
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Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques by Koffie, Robert M, Meyer-Luehmann, Melanie, Hashimoto, Tadafumi, Adams, Kenneth W, Mielke, Matthew L, Garcia-Alloza, Monica, Micheva, Kristina D, Smith, Stephen J, Kim, M. Leo, Lee, Virginia M, Hyman, Bradley T, Spires-Jones, Tara L

“…Synapse loss correlates with a cognitive decline in Alzheimer's disease (AD), but whether this is caused by fibrillar deposits known as senile plaques or…”
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