Search Results - "L Costa, Silvia"

Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies by de Almeida, Raquel B M, Barbosa, Deyse B, do Bomfim, Mayra R, Amparo, Jéssika A O, Andrade, Bruno S, Costa, Silvia L, Campos, Joaquín M, Cruz, Jorddy N, Santos, Cleydson B R, Leite, Franco H A, Botura, Mariana B

“…The enhancement of cholinergic functions via acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic…”
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Three New Polyprenylated Benzophenone Derivatives Isolated from Clusia burle-marxii by C Silva, Maria do Carmo, V Carvalho, Fernanda, G Ferreira, Antonio, Venâncio, Tiago, G F da Silva, Maria Fátima, A Silva, Victor Diogenes, L Costa, Silvia, G Ferraz, Caline G, Ribeiro, Paulo Roberto

“…Three new polyprenylated benzophenone derivatives named burlemarxione G-I (1-3) were isolated from C. burle-marxii trunks (compound 1) and leaves (compounds 2…”
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Technological Maturity and Systematic Review of Medicinal Plants with Pharmacological Activity in the Central Nervous System by Bastos, Eduardo M S, da Silva, Victor D A, Costa, Silvia L, Hanna, Samira A

“…Medicinal plants present activities against neurodegenerative diseases with potential for the pharmaceutical industries. Therefore, the objective of this study…”
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Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats by do Nascimento, Ravena P, de Jesus, Lívia B, Oliveira-Junior, Markley S, Almeida, Aurea M, Moreira, Eduardo L T, Paredes, Bruno D, David, Jorge M, Souza, Bruno S F, de Fátima D Costa, Maria, Butt, Arthur M, Silva, Victor Diogenes A, Costa, Silvia L

“…Agathisflavone is a flavonoid with anti-neuroinflammatory and myelinogenic properties, being also capable to induce neurogenesis. This study evaluated the…”
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Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite) by Silva, Victor D A, Cuevas, Carlos, Muñoz, Patricia, Villa, Monica, Ahumada-Castro, Ulises, Huenchuguala, Sandro, Santos, Cleonice C Dos, Araujo, Fillipe M DE, Ferreira, Rafael S, Silva, Vanessa B DA, Silva, Juliana H C E, Soares, Érica N, Velozo, Eudes S, Segura-Aguilar, Juan, Costa, Silvia L

“…Prosopis juliflora is a shrub that has been used to feed animals and humans. However, a synergistic action of piperidine alkaloids has been suggested to be…”
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Role of Microgliosis and NLRP3 Inflammasome in Parkinson’s Disease Pathogenesis and Therapy by de Araújo, Fillipe M., Cuenca-Bermejo, Lorena, Fernández-Villalba, Emiliano, Costa, Silvia L., Silva, Victor Diogenes A., Herrero, Maria Trinidad

“…Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting…”
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Combination of a multiplatform metabolite profiling approach and chemometrics as a powerful strategy to identify bioactive metabolites in Lepidium meyenii (Peruvian maca) by Carvalho, Fernanda V., Fonseca Santana, Lucia, Diogenes A. da Silva, Victor, Costa, Silvia L., Zambotti-Villelae, Leonardo, Colepicolo, Pio, Ferraz, Caline G., Ribeiro, Paulo R.

“…[Display omitted] •The chemical profile and bioactivity of L. meyenii extracts were assessed.•Seventy-five metabolites were identified in the extracts by…”
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Identification of bioactive metabolites from corn silk extracts by a combination of metabolite profiling, univariate statistical analysis and chemometrics by da Hora, Natan R.S., Santana, Lucia F., da Silva, Victor Diogenes A., Costa, Silvia L., Zambotti-Villela, Leonardo, Colepicolo, Pio, Ferraz, Caline G., Ribeiro, Paulo R.

“…[Display omitted] •The composition and bioactivity of corn silk extracts were assessed.•Thirty-four metabolites were identified in the extracts by HPLC-MS and…”
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Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression by Santos, Balbino L., Oliveira, Mona N., Coelho, Paulo L.C., Pitanga, Bruno P.S., da Silva, Alessandra B., Adelita, Taís, Silva, Victor Diógenes A., Costa, Maria de F.D., El-Bachá, Ramon S., Tardy, Marcienne, Chneiweiss, Hervé, Junier, Marie-Pierre, Moura-Neto, Vivaldo, Costa, Silvia L.

“…The malignant gliomas are very common primary brain tumors with poor prognosis, which require more effective therapies than the current used, such as with…”
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Reverted effect of mesenchymal stem cells in glioblastoma treated with agathisflavone and its selective antitumoral effect on cell viability, migration, and differentiation via STAT3 by Nascimento, Ravena P., Santos, Balbino L., Silva, Karina C., Amaral da Silva, Victor D., Fátima Costa, Maria, David, Jorge M., David, Juceni P., Moura‐Neto, Vivaldo, Oliveira, Mona das N., Ulrich, Henning, Faria Lopes, Giselle P., Costa, Silvia L.

“…Glioblastoma is the most lethal tumor of the central nervous system, presenting a very poor prognostic, with a survival around 16 months. The interaction of…”
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Apigenin from Croton betulaster Müll restores the immune profile of microglia against glioma cells by Coelho, Paulo L.C., Amparo, Jéssika A.O., Silva, Alessandra B., Silva, Karina C., Braga‐de‐Souza, Suzana, Barbosa, Pedro Rocha, Lopes, Giselle P. de F., Costa, Silvia L.

“…The flavonoid apigenin, extracted from the Brazilian plant Croton betulaster Müll. has demonstrated the ability to inhibit proliferation, induce…”
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Monocrotaline induces acutely cerebrovascular lesions, astrogliosis and neuronal degeneration associated with behavior changes in rats: A model of vascular damage in perspective by Silva, Adriana L., Oliveira, Joana L., do Nascimento, Ravena P., Santos, Letícia O., de Araújo, Fillipe M., dos Santos, Balbino L., Santana, Rejane C., Moreira, Eduardo Luiz T., Batatinha, Maria José M., Alves, Iura M., Velozo, Eudes S., Victor, Mauricio M., Assis, Adriano M., Almeida, Roberto F., de Souza, Diogo O.G., Silva, Victor Diógenes A., Costa, Silvia L.

“…Pyrrolizidine alkaloids (PAs) are secondary plant metabolites playing an important role as phytotoxins in the plant defense mechanisms and can be present as…”
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A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo by Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Hansel, Gisele, Simões Pires, Elisa Nicoloso, Merino, Nelson, Valdes, Odalys, Delgado-Hernández, René, Parra, Alicia Lagarto, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Salbego, Christianne, Costa, Silvia L., Souza, Diogo O., Pardo-Andreu, Gilberto L.

“…We previously showed that JM-20, a novel 1,5-benzodiazepine fused to a dihydropyridine moiety, possessed an anxiolytic profile similar to diazepam and strong…”
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Aminochrome induces microglia and astrocyte activation by Santos, Cleonice C., Araújo, Fillipe M., Ferreira, Rafael S., Silva, Vanessa B., Silva, Juliana H.C., Grangeiro, Maria S., Soares, Érica N., Pereira, Érica Patricia L., Souza, Cleide S., Costa, Silvia L., Segura-Aguilar, Juan, Silva, Victor Diogenes A.

“…Aminochrome has been suggested as a more physiological preclinical model capable of inducing five of the six mechanisms of Parkinson's Disease (PD). Until now,…”
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Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures by de Araújo, Fillipe M., Ferreira, Rafael S., Souza, Cleide S., dos Santos, Cleonice Creusa, Rodrigues, Tácio L.R.S., e Silva, Juliana Helena C., Gasparotto, Juciano, Gelain, Daniel Pens, El-Bachá, Ramon S., D. Costa, Maria de Fátima, Fonseca, José Claudio M., Segura-Aguilar, Juan, Costa, Silvia L., Silva, Victor Diogenes A.

“…•Aminochrome induces toxicity in midbrain slice cultures.•Aminochrome induces neuroinflammation in midbrain slice cultures.•Aminochrome reduces NGF and GDNF…”
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The flavonoid apigenin from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells by Coelho, Paulo L.C, Oliveira, Mona N, da Silva, Alessandra B, Pitanga, Bruno P.S, Silva, Victor D.A, Faria, Giselle P, Sampaio, Geraldo P, Costa, Maria de Fatima D, Braga-de-Souza, Suzana, Costa, Silvia L

“…This study aimed to investigate the antitumor and immunomodulatory properties of the flavonoid apigenin (5,7,4′-trihydroxyflavone), which was extracted from…”
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Rutin improves glutamate uptake and inhibits glutamate excitotoxicity in rat brain slices by Ferreira, Rafael S., Teles-Souza, Jéssica, dos Santos Souza, Cleide, Pereira, Érica P. L., de Araújo, Fillipe M., da Silva, Alessandra Bispo, Castro e Silva, Juliana H., Nonose, Yasmine, Núñez-Figueredo, Yanier, de Assis, Adriano M., Souza, Diogo O., Costa, Maria de Fátima D., Moreira, José Cláudio F., Costa, Silvia L., da Silva, Victor D. A.

“…Rutin is an important flavonoid consumed in the daily diet. It is also known as vitamin P and has been extensively investigated due to its pharmacological…”
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Involvement of astrocytic CYP1A1 isoform in the metabolism and toxicity of the alkaloid pyrrolizidine monocrotaline by Nascimento, Ravena P., Oliveira, Joana L., Carvalho, José Leilton C., Santos, William A., Pires, Thyago Rubens C., Batatinha, Maria José M., El-Bachá, Ramon S., Silva, Victor Diógenes A., Costa, Silvia L.

“…Monocrotaline (MCT) and its pyrrole derivative, dehydromonocrotaline (DHMC), interact with molecular targets in cells of the central nervous system. DHMC…”
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Juliprosopine and Juliprosine from Prosopis juliflora Leaves Induce Mitochondrial Damage and Cytoplasmic Vacuolation on Cocultured Glial Cells and Neurons by Silva, Victor Diogenes A, Pitanga, Bruno P. S, Nascimento, Ravena P, Souza, Cleide S, Coelho, Paulo Lucas C, Menezes-Filho, Noélio, Silva, André Mário M, Costa, Maria de Fátima D, El-Bachá, Ramon S, Velozo, Eudes S, Costa, Silvia L

“…Prosopis juliflora is a shrub largely used for animal and human consumption. However, ingestion has been shown to induce intoxication in animals, which is…”
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Saponin-rich fraction from Agave sisalana: effect against malignant astrocytic cells and its chemical characterisation by ESI-MS/MS by de Oliveira, João Victor A., Botura, Mariana B., dos Santos, Jener D. G., Argolo, Deivison S., da Silva, Victor Diogenes A., da Silva, Gisele D., de Lima, Hélimar G., Braz Filho, Raimundo, Vieira, Ivo Jose C., Branco, Alexsandro, Batatinha, Maria José M., Costa, Silvia L.

“…Astrocytic tumour cells derived from human (GL-15) and rat (C6) gliomas, as well as non-tumoural astrocytic cells, were exposed to the saponin-rich fraction…”
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