Childhood adverse experiences and clinical manifestations in women with systemic lupus erythematosus

Background Patients with a history of adverse childhood experiences (ACEs) have a higher incidence of developing autoimmune diseases such as systemic lupus erythematosus. Objective The objective is to associate the ACE with the clinical manifestations of SLE in adult women. Methods This is a cross-s...

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Bibliographic Details
Published in:	Lupus Vol. 33; no. 5; pp. 511 - 519
Main Authors:	Esteves Rossini, Elisa, Lourival Zanoveli Cunha, Jonatas, L B Costa, Gabriela, Araujo Melo, Karin, Cassemiro Micheleto, José Pedro, Miranda Pereira Fausto, Vanessa, Quintiliano Pedroza, Laís, Sotero Fragoso, Thiago, Leão de Melo Neto, Valfrido, Cavalcante Oliveira, Michelle Jacintha
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-04-2024 Sage Publications Ltd
Subjects:	Adverse childhood experiences Autoimmune diseases Children Diabetes mellitus Lupus Medical records Nephritis Photosensitivity Sjogren's syndrome Systemic lupus erythematosus Trauma Ulcers Womens health clinical manifestations Adverse childhood experiences systemic lupus erythematosus
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Summary:	Background Patients with a history of adverse childhood experiences (ACEs) have a higher incidence of developing autoimmune diseases such as systemic lupus erythematosus. Objective The objective is to associate the ACE with the clinical manifestations of SLE in adult women. Methods This is a cross-sectional observational analytical study in a sample of women diagnosed with SLE, whose data were collected through interviews and a review of medical records. The ACE were identified using the Childhood Trauma Questionnaire (CTQ) and were associated with sociodemographic and clinical data, as well as the presence of harm. Results The sample was composed of 97 women. In this study, significant associations were found between physical abuse and oral ulcers (p = .006) and nephritis (p = .032); between sexual abuse and Sjogren’s syndrome (p = .024) and oral ulcers (p = .035); between physical neglect and photosensitivity (p = .024) and oral ulcers (p = .039); and between emotional neglect and diabetes mellitus (p = .033). Conclusion Individuals with a positive history of ACE have significant associations with certain clinical manifestations of SLE and subtypes of ACE, underscoring the importance of preventing childhood trauma to improve adult health. Further studies are needed to elucidate the impact of ACE on adult health.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0961-2033 1477-0962
DOI:	10.1177/09612033241238056