Search Results - "Lüthi, U"

The CASBAH: a searchable database of caspase substrates by Lüthi, A U, Martin, S J

“…Apoptosis is coordinated by members of the caspase family of aspartic acid-specific proteases. Other members of this protease family also play essential roles…”
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Ongoing MRI remodeling 3–7 years after collagen meniscus implantation in stable knees by Schenk, L., Bethge, L., Hirschmann, A., Berbig, R., Lüthi, U., Arnold, M. P., Hirschmann, Michael T.

“…Purpose The purpose of the present study was to evaluate the clinical and radiological 3–7 years outcomes of patients who underwent collagen meniscus…”
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Executioner caspase-3 and caspase-7 are functionally distinct proteases by Walsh, John G, Cullen, Sean P, Sheridan, Clare, Lüthi, Alexander U, Gerner, Christopher, Martin, Seamus J

“…Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis. Because the major…”
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Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α by Afonina, Inna S., Tynan, Graham A., Logue, Susan E., Cullen, Sean P., Bots, Michael, Lüthi, Alexander U., Reeves, Emer P., McElvaney, Noel G., Medema, Jan P., Lavelle, Ed C., Martin, Seamus J.

“…Granzyme B is a cytotoxic lymphocyte-derived protease that plays a central role in promoting apoptosis of virus-infected target cells, through direct…”
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Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases by Lüthi, Alexander U., Cullen, Sean P., McNeela, Edel A., Duriez, Patrick J., Afonina, Inna S., Sheridan, Clare, Brumatti, Gabriela, Taylor, Rebecca C., Kersse, Kristof, Vandenabeele, Peter, Lavelle, Ed C., Martin, Seamus J.

“…Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to…”
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Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme by Walsh, John G., Logue, Susan E., Lüthi, Alexander U., Martin, Seamus J.

“…Members of the caspase family of cysteine proteases coordinate the highly disparate processes of apoptosis and inflammation. However, although hundreds of…”
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One-year clinical and MR imaging outcome after partial meniscal replacement in stabilized knees using a collagen meniscus implant by Hirschmann, M. T., Keller, L., Hirschmann, A., Schenk, L., Berbig, R., Lüthi, U., Amsler, F., Friederich, N. F., Arnold, M. P.

“…Purpose The purpose of the study was to evaluate the clinical and radiological outcomes after medial/lateral collagen meniscus substitution (CMI) at 12 months…”
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Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53 by Grob, T J, Novak, U, Maisse, C, Barcaroli, D, Lüthi, A U, Pirnia, F, Hügli, B, Graber, H U, De Laurenzi, V, Fey, M F, Melino, G, Tobler, A

“…Inactivation of the tumour suppressor p53 is the most common defect in cancer cells. p53 is a sequence specific transcription factor that is activated in…”
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Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins by Bordoli, L, Netsch, M, Lüthi, U, Lutz, W, Eckner, R

“…p300 and CBP participate as transcriptional coregulators in the execution of a wide spectrum of cellular gene expression programs controlling cell…”
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Functional analysis of the p300 acetyltransferase domain: the PHD finger of p300 but not of CBP is dispensable for enzymatic activity by Bordoli, L, Hüsser, S, Lüthi, U, Netsch, M, Osmani, H, Eckner, R

“…Acetylation of nucleosomal histones is a major regulatory step during activation of eukaryotic gene expression. Among the known acetyltransferase (AT)…”
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Manufacture of a Cell-free Amnion Matrix Scaffold that Supports Amnion Cell Outgrowth In Vitro by Portmann-Lanz, C.B, Ochsenbein-Kölble, N, Marquardt, K, Lüthi, U, Zisch, A, Zimmermann, R

“…Abstract We manufactured a cell-free extracellular matrix scaffolds in order to obtain a support material for amnion cell outgrowth, eventually being used for…”
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Human and murine granzyme B exhibit divergent substrate preferences by Cullen, Sean P, Adrain, Colin, Lüthi, Alexander U, Duriez, Patrick J, Martin, Seamus J

“…The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can…”
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Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase by Raghunath, M, Höpfner, B, Aeschlimann, D, Lüthi, U, Meuli, M, Altermatt, S, Gobet, R, Bruckner-Tuderman, L, Steinmann, B

“…Since transglutaminases create covalent gamma-glutamyl-epsilon-lysine cross-links between extracellular matrix proteins they are prime candidates for…”
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Some, but not all, glycine substitution mutations in COL7A1 result in intracellular accumulation of collagen VII, loss of anchoring fibrils, and skin blistering by Hammami-Hauasli, N, Schumann, H, Raghunath, M, Kilgus, O, Lüthi, U, Luger, T, Bruckner-Tuderman, L

“…COL7A1 gene mutations cause dystrophic epidermolysis bullosa, a skin blistering disorder. The phenotypes result from defects of collagen VII, the major…”
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Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase by Middendorp, Oliver, Lüthi, Urs, Hausch, Felix, Barberis, Alcide

“…The beta-secretase BACE1 is an attractive drug target for reducing the level of the Alzheimer's disease-promoting Abeta peptide in the brain. Whereas potent…”
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Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing by Cullen, Sean P., Afonina, Inna S., Donadini, Roberta, Lüthi, Alexander U., Medema, Jan Paul, Bird, Phillip I., Martin, Seamus J.

“…Natural killer (NK) cells kill virus-infected or transformed target cells by delivering cytotoxic proteases called granzymes to the target cell cytosol. One of…”
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Analysis of apoptosis in cell-free systems by Cullen, Sean P., Lüthi, Alexander U., Martin, Seamus J.

“…Cell-free systems have been instrumental in the identification of several important components of the cell death machinery such as cytochrome c, APAF-1,…”
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Rheumatic symptoms in a malignant disease by Röpke, B, Lüthi, U, Bargetzi, M, Michot, M

“…We report a case of a 75 year old women with increasing deterioration of her general condition. We found a massive lymphadenopathy, an impressive exanthem and…”
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Three Novel Homozygous Point Mutations and a New Polymorphism in the COL17A1 Gene: Relation to Biological and Clinical Phenotypes of Junctional Epidermolysis Bullosa by Schumann, Hauke, Hammami-Hauasli, Nadja, Pulkkinen, Leena, Mauviel, Alain, Küster, Wolfgang, Lüthi, Ursula, Owaribe, Katsushi, Uitto, Jouni, Bruckner-Tuderman, Leena

“…Junctional epidermolysis bullosa (JEB) is a clinically and biologically heterogeneous genodermatosis, characterized by trauma-induced blistering and healing…”
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Irrigation drainage with intracatheter in severe infections of the hand by Mark, G, Lüthi, U, Geel, C, Rüedi, T

“…Severe infections of the hand and fingers still challenge the surgeon's skill in spite of modern antibiotics. Very often patients are referred too late, with…”
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