Search Results - "Lüscher, P."

Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis oocytes system by Clémençon, Benjamin, Lüscher, Benjamin P, Fine, Michael, Baumann, Marc U, Surbek, Daniel V, Bonny, Olivier, Hediger, Matthias A

“…The urate transporter, GLUT9, is responsible for the basolateral transport of urate in the proximal tubule of human kidneys and in the placenta, playing a…”
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Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice by Deisl, Christine, Anderegg, Manuel, Albano, Giuseppe, Lüscher, Benjamin P, Cerny, David, Soria, Rodrigo, Bouillet, Elisa, Rimoldi, Stefano, Scherrer, Urs, Fuster, Daniel G

“…We previously demonstrated that the sodium/hydrogen exchanger NHA2, also known as NHEDC2 or SLC9B2, is critical for insulin secretion by β-cells. To gain more…”
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Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system by Clémençon, Benjamin, Lüscher, Benjamin P., Hediger, Matthias A.

“…Membrane proteins represent roughly one third of the human proteome and many of them serve as targets of therapeutic drugs. An exception is the SLC solute…”
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Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System by Lüscher, Benjamin P, Albrecht, Christiane, Stieger, Bruno, Surbek, Daniel V, Baumann, Marc U

“…Hyperuricemia is a common laboratory finding in pregnant women compromised by preeclampsia. A growing body of evidence suggests that uric acid is involved in…”
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Different Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia by Lüscher, Benjamin P, Surbek, Daniel V, Clémençon, Benjamin, Huang, Xiao, Albrecht, Christiane, Marini, Camilla, Hediger, Matthias A, Baumann, Marc U

“…Glucose transporter 9 (GLUT9/SLC2A9) is the major regulator of uric acid homeostasis in humans. Hyperuricemia due to impaired regulation by GLUT9 in pregnancy…”
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Use of concatamers to study GABAA receptor architecture and function: application to delta-subunit-containing receptors and possible pitfalls by Sigel, Erwin, Kaur, Kuldeep H, Lüscher, Benjamin P, Baur, Roland

“…Many membrane proteins, including the GABA(A) [GABA (gamma-aminobutyric acid) type A] receptors, are oligomers often built from different subunits. As an…”
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Cl - as a bona fide signaling ion by Lüscher, Benjamin P, Vachel, Laura, Ohana, Ehud, Muallem, Shmuel

“…Cl is the major extracellular (Cl ) and intracellular (Cl ) anion whose concentration is actively regulated by multiple transporters. These transporters…”
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Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding site by Lüscher, Benjamin P, Baur, Roland, Goeldner, Maurice, Sigel, Erwin

“…Classical benzodiazepines, such as diazepam, interact with α(x)β(2)γ(2) GABA(A) receptors, x = 1, 2, 3, 5 and modulate their function. Modulation of different…”
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Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia by Lüscher, Benjamin P., PhD, Marini, Camilla, Joerger-Messerli, Marianne, Huang, Xiao, Hediger, Matthias A, Albrecht, Christiane, Surbek, Daniel V, Baumann, Marc U

“…Abstract Introduction Transplacental fetal glucose supply is predominantly regulated by glucose transporter-1 (GLUT1). Altered expression and/or function of…”
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Duration of Pregnancy After Carbon Dioxide Laser Conization of the Cervix: Influence of Cone Height by Raio, Luigi, Ghezzi, Fabio, Di Naro, Edoardo, Gomez, Ricardo, Lüscher, Klaus P

“…Objective: To determine if carbon dioxide laser conization of the cervix is a risk factor for preterm delivery in subsequent gestations and to evaluate whether…”
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Neurotoxin Merging: A Strategy Deployed by the Venom of the Spider Cupiennius salei to Potentiate Toxicity on Insects by Clémençon, Benjamin, Kuhn-Nentwig, Lucia, Langenegger, Nicolas, Kopp, Lukas, Peigneur, Steve, Tytgat, Jan, Nentwig, Wolfgang, Lüscher, Benjamin P

“…The venom of is composed of dozens of neurotoxins, with most of them supposed to act on ion channels. Some insecticidal monomeric neurotoxins contain an…”
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Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice by Lüscher, Benjamin P, Schoeberlein, Andreina, Surbek, Daniel V, Baumann, Marc U

“…Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria. The role of…”
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Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria by Dhayat, Nasser, Simonin, Alexandre, Anderegg, Manuel, Pathare, Ganesh, Lüscher, Benjamin P, Deisl, Christine, Albano, Giuseppe, Mordasini, David, Hediger, Matthias A, Surbek, Daniel V, Vogt, Bruno, Sass, Jörn Oliver, Kloeckener-Gruissem, Barbara, Fuster, Daniel G

“…A heterozygous mutation (c.643C>A; p.Q215X) in the monocarboxylate transporter 12-encoding gene MCT12 (also known as SLC16A12) that mediates creatine transport…”
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Influence of GABAA Receptor α Subunit Isoforms on the Benzodiazepine Binding Site by Lüscher, Benjamin P., Baur, Roland, Goeldner, Maurice, Sigel, Erwin

“…Classical benzodiazepines, such as diazepam, interact with αxβ2γ2 GABAA receptors, x = 1, 2, 3, 5 and modulate their function. Modulation of different receptor…”
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GLUT1-down-regulation leads to a “premature senescence” in preeclamptic syncytiotrophoblasts by Marini, Camilla, Lüscher, Benjamin P, Surbek, Daniel V, Baumann, Marc U

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Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs by Baur, Roland, Tan, Kelly R, Lüscher, Benjamin P, Gonthier, Anne, Goeldner, Maurice, Sigel, Erwin

“…Classical benzodiazepines, for example diazepam, interact with αxβ₂γ₂ GABAA receptors, x = 1, 2, 3, 5. Little is known about effects of α subunits on the…”
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Prenatal assessment of Wharton's jelly in umbilical cords with single artery by Raio, L., Ghezzi, F., Di Naro, E., Franchi, M., Brühwiler, H., Lüscher, K. P.

“…Objective To investigate whether the amount of Wharton's jelly in non‐malformed fetuses with a single umbilical artery is different from that of fetuses with a…”
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A Venom-derived Neurotoxin, CsTx-1, from the Spider Cupiennius salei Exhibits Cytolytic Activities by Kuhn-Nentwig, Lucia, Fedorova, Irina M., Lüscher, Benjamin P., Kopp, Lukas S., Trachsel, Christian, Schaller, Johann, Vu, Xuan Lan, Seebeck, Thomas, Streitberger, Kathrin, Nentwig, Wolfgang, Sigel, Erwin, Magazanik, Lev G.

“…Background: CsTx-1, an ICK motif containing neurotoxin, acts as L-type Ca2+-channel inhibitor. Results: The partial α-helical C terminus of CsTx-1 exhibits…”
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505: Down-regulation of placental glucose transporter (GLUT)-1 in pre-eclampsia by marini, camilla, Lüscher, Benjamin P, Joerger-Messerli, Marianne, Huang, Xiao, Albrecht, Christiane, Hediger, Matthias A, Surbek, Daniel V, Baumann, Marc U

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Does mycorrhizal inoculation improve plant survival, aggregate stability, and fine root development on a coarse‐grained soil in an alpine eco‐engineering field experiment? by Bast, A., Wilcke, W., Graf, F., Lüscher, P., Gärtner, H.

“…Steep vegetation‐free talus slopes in high mountain environments are prone to superficial slope failures and surface erosion. Eco‐engineering measures can…”
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