Search Results - "Lüchtenborg, Christian"

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites by Malek, Mouhannad, Wawrzyniak, Anna M., Koch, Peter, Lüchtenborg, Christian, Hessenberger, Manuel, Sachsenheimer, Timo, Jang, Wonyul, Brügger, Britta, Haucke, Volker

“…Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of tethers to contact…”
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The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles by Trautz, Birthe, Wiedemann, Hannah, Lüchtenborg, Christian, Pierini, Virginia, Kranich, Jan, Glass, Bärbel, Kräusslich, Hans-Georg, Brocker, Thomas, Pizzato, Massimo, Ruggieri, Alessia, Brügger, Britta, Fackler, Oliver T.

“…The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV, type 1 (HIV-1) particles, and is counteracted by the viral pathogenesis…”
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TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis by Christodoulou, Andri, Maimaris, Giannis, Makrigiorgi, Andri, Charidemou, Evelina, Lüchtenborg, Christian, Ververis, Antonis, Georgiou, Renos, Lederer, Carsten W, Haffner, Christof, Brügger, Britta, Santama, Niovi

“…The structurally and functionally complex endoplasmic reticulum (ER) hosts critical processes including lipid synthesis. Here, we focus on the functional…”
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Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation by Tabata, Keisuke, Prasad, Vibhu, Paul, David, Lee, Ji-Young, Pham, Minh-Tu, Twu, Woan-Ing, Neufeldt, Christopher J., Cortese, Mirko, Cerikan, Berati, Stahl, Yannick, Joecks, Sebastian, Tran, Cong Si, Lüchtenborg, Christian, V’kovski, Philip, Hörmann, Katrin, Müller, André C., Zitzmann, Carolin, Haselmann, Uta, Beneke, Jürgen, Kaderali, Lars, Erfle, Holger, Thiel, Volker, Lohmann, Volker, Superti-Furga, Giulio, Brügger, Britta, Bartenschlager, Ralf

“…Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are…”
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Molecular and structural architecture of polyQ aggregates in yeast by Gruber, Anselm, Hornburg, Daniel, Antonin, Matthias, Krahmer, Natalie, Collado, Javier, Schaffer, Miroslava, Zubaite, Greta, Lüchtenborg, Christian, Sachsenheimer, Timo, Brügger, Britta, Mann, Matthias, Baumeister, Wolfgang, Hartl, F. Ulrich, Hipp, Mark S., Fernández-Busnadiego, Rubén

“…Huntington’s disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-terminal exon of huntingtin (HttEx1), but the cellular mechanisms…”
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Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins by Nůsková, Hana, Serebryakova, Marina V., Ferrer-Caelles, Anna, Sachsenheimer, Timo, Lüchtenborg, Christian, Miller, Aubry K., Brügger, Britta, Kordyukova, Larisa V., Teleman, Aurelio A.

“…Covalent attachment of C16:0 to proteins (palmitoylation) regulates protein function. Proteins are also S-acylated by other fatty acids including C18:0…”
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Metabolic memory underlying minimal residual disease in breast cancer by Radic Shechter, Ksenija, Kafkia, Eleni, Zirngibl, Katharina, Gawrzak, Sylwia, Alladin, Ashna, Machado, Daniel, Lüchtenborg, Christian, Sévin, Daniel C, Brügger, Britta, Patil, Kiran R, Jechlinger, Martin

“…Tumor relapse from treatment‐resistant cells (minimal residual disease, MRD) underlies most breast cancer‐related deaths. Yet, the molecular characteristics…”
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Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver by Aich, Abhishek, Boshnakovska, Angela, Witte, Steffen, Gall, Tanja, Unthan-Fechner, Kerstin, Yousefi, Roya, Chowdhury, Arpita, Dahal, Drishan, Methi, Aditi, Kaufmann, Svenja, Silbern, Ivan, Prochazka, Jan, Nichtova, Zuzana, Palkova, Marcela, Raishbrook, Miles, Koubkova, Gizela, Sedlacek, Radislav, Tröder, Simon E., Zevnik, Branko, Riedel, Dietmar, Michanski, Susann, Möbius, Wiebke, Ströbel, Philipp, Lüchtenborg, Christian, Giavalisco, Patrick, Urlaub, Henning, Fischer, Andre, Brügger, Britta, Jakobs, Stefan, Rehling, Peter

“…Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific…”
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Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects by van Hensbergen, Vincent P, Movert, Elin, de Maat, Vincent, Lüchtenborg, Christian, Le Breton, Yoann, Lambeau, Gérard, Payré, Christine, Henningham, Anna, Nizet, Victor, van Strijp, Jos A G, Brügger, Britta, Carlsson, Fredric, McIver, Kevin S, van Sorge, Nina M

“…Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in…”
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Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia by Chowdhury, Arpita, Aich, Abhishek, Jain, Gaurav, Wozny, Katharina, Lüchtenborg, Christian, Hartmann, Magnus, Bernhard, Olaf, Balleiniger, Martina, Alfar, Ezzaldin Ahmed, Zieseniss, Anke, Toischer, Karl, Guan, Kaomei, Rizzoli, Silvio O., Brügger, Britta, Fischer, Andrè, Katschinski, Dörthe M., Rehling, Peter, Dudek, Jan

“…Mitochondria fulfill vital metabolic functions and act as crucial cellular signaling hubs, integrating their metabolic status into the cellular context. Here,…”
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Oral batyl alcohol supplementation rescues decreased cardiac conduction in ether phospholipid‐deficient mice by Todt, Hannes, Dorninger, Fabian, Rothauer, Peter J., Fischer, Claus M., Schranz, Michael, Bruegger, Britta, Lüchtenborg, Christian, Ebner, Janine, Hilber, Karlheinz, Koenig, Xaver, Erdem, Fatma A., Gawali, Vaibhavkumar S., Berger, Johannes

“…Plasmalogens (Pls) are a class of membrane phospholipids which serve a number of essential biological functions. Deficiency of Pls is associated with common…”
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Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome by Chowdhury, Arpita, Boshnakovska, Angela, Aich, Abhishek, Methi, Aditi, Vergel Leon, Ana Maria, Silbern, Ivan, Lüchtenborg, Christian, Cyganek, Lukas, Prochazka, Jan, Sedlacek, Radislav, Lindovsky, Jiri, Wachs, Dominic, Nichtova, Zuzana, Zudova, Dagmar, Koubkova, Gizela, Fischer, André, Urlaub, Henning, Brügger, Britta, Katschinski, Dörthe M, Dudek, Jan, Rehling, Peter

“…Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS) is a severe disorder, due to dysfunction of the mitochondrial…”
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Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions by Gerl, Mathias J, Bittl, Verena, Kirchner, Susanne, Sachsenheimer, Timo, Brunner, Hanna L, Lüchtenborg, Christian, Özbalci, Cagakan, Wiedemann, Hannah, Wegehingel, Sabine, Nickel, Walter, Haberkant, Per, Schultz, Carsten, Krüger, Marcus, Brügger, Britta

“…Cell membranes contain hundreds to thousands of individual lipid species that are of structural importance but also specifically interact with proteins. Due to…”
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A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis by Zhang, Wanlu, Khan, Azqa, Vitale, Jlenia, Neuner, Annett, Rink, Kerstin, Lüchtenborg, Christian, Brügger, Britta, Söllner, Thomas H, Schiebel, Elmar

“…The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex…”
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Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy by Kleinecke, Sandra, Richert, Sarah, de Hoz, Livia, Brügger, Britta, Kungl, Theresa, Asadollahi, Ebrahim, Quintes, Susanne, Blanz, Judith, McGonigal, Rhona, Naseri, Kobra, Sereda, Michael W, Sachsenheimer, Timo, Lüchtenborg, Christian, Möbius, Wiebke, Willison, Hugh, Baes, Myriam, Nave, Klaus-Armin, Kassmann, Celia Michèle

“…Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease…”
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A novel neurodegenerative spectrum disorder in patients with MLKL deficiency by Faergeman, Soren L., Evans, Hayley, Attfield, Kathrine E., Desel, Christiane, Kuttikkatte, Subita Balaram, Sommerlund, Mette, Jensen, Lise Torp, Frokiaer, Jorgen, Friese, Manuel A., Matthews, Paul M., Luchtenborg, Christian, Brügger, Britta, Oturai, Annette Bang, Dendrou, Calliope A., Fugger, Lars

“…Mixed lineage kinase domain-like (MLKL) is the main executor of necroptosis, an inflammatory form of programmed cell death. Necroptosis is implicated in…”
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Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex by Papagiannidis, Dimitrios, Bircham, Peter W, Lüchtenborg, Christian, Pajonk, Oliver, Ruffini, Giulia, Brügger, Britta, Schuck, Sebastian

“…Cells dynamically adapt organelle size to current physiological demand. Organelle growth requires membrane biogenesis and therefore needs to be coordinated…”
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Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase by Avci, Dönem, Heidasch, Ronny, Costa, Martina, Lüchtenborg, Christian, Kale, Dipali, Brügger, Britta, Lemberg, Marius K.

“…Intramembrane proteolysis regulates important processes such as signaling and transcriptional and posttranslational abundance control of proteins with key…”
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Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis by Zhang, Wanlu, Neuner, Annett, Rüthnick, Diana, Sachsenheimer, Timo, Lüchtenborg, Christian, Brügger, Britta, Schiebel, Elmar

“…The paralogous Brr6 and Brl1 are conserved integral membrane proteins of the nuclear envelope (NE) with an unclear role in nuclear pore complex (NPC)…”
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Lipid Profiles of Five Essential Phospholipid Preparations for the Treatment of Nonalcoholic Fatty Liver Disease: A Comparative Study by Lüchtenborg, Christian, Niederhaus, Birgit, Brügger, Britta, Popovic, Branko, Fricker, Gert

“…Nonalcoholic fatty liver disease (NAFLD) is associated with an imbalance in fatty acid composition and can progress from simple steatosis to steatohepatitis,…”
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