Search Results - "Lúðvíksdóttir, Dora"
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Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
Published in Nature communications (20-01-2020)“…Asthma is one of the most common chronic diseases affecting both children and adults. We report a genome-wide association meta-analysis of 69,189 cases and…”
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Eosinophilic granulomatosis with polyangiitis, a case report
Published in Laeknabladid (05-01-2024)“…A 72-year-old woman presented to the emergency department due to worsening dyspnea. She had been diagnosed with asthma a year earlier. At arrival, her oxygen…”
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Eight-year follow-up of airway hyperresponsiveness in patients with primary Sjögren's syndrome
Published in Upsala journal of medical sciences (01-03-2017)“…Objective: To evaluate in a longitudinal study the influence of airway hyperresponsiveness (AHR) on lung function in patients with primary Sjögren's syndrome…”
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Application of nitric oxide measurements in clinical conditions beyond asthma
Published in European clinical respiratory journal (01-01-2015)“…Fractional exhaled nitric oxide (FeNO) is a convenient, non-invasive method for the assessment of active, mainly Th2-driven, airway inflammation, which is…”
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Ultrastructure of bronchial biopsies from patients with allergic and non-allergic asthma
Published in Respiratory medicine (01-04-2005)“…Epithelial damage is commonly found in airways of asthma patients. The aim of this study was to investigate epithelial damage in allergic and non-allergic…”
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Heterogeneity in the use of biologics for severe asthma in Europe: a SHARP ERS study
Published in ERJ open research (01-10-2022)“…Introduction Treatment with biologics for severe asthma is informed by international and national guidelines and defined by national regulating bodies, but how…”
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Habitual coughing and its associations with asthma, anxiety, and gastroesophageal reflux
Published in Chest (01-05-1996)“…Coughing was studied in relation to different disorders and objective variables indicative of airway inflammation. A random sample of 800 persons, aged 20 to…”
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A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
Published in Nature genetics (01-02-2019)“…Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide…”
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Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma
Published in American journal of respiratory and critical care medicine (01-12-2000)Get full text
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A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
Published in PLoS genetics (08-03-2017)“…IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic…”
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International Severe Asthma Registry: Mission Statement
Published in Chest (01-04-2020)“…Regional and/or national severe asthma registries provide valuable country-specific information. However, they are often limited in scope within the broader…”
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A partial loss-of-function variant in STAT6 protects against type 2 asthma
Published in Journal of allergy and clinical immunology (16-10-2024)“…Signal transducer and activator of transcription 6 (STAT6) is central to type 2 (T2) inflammation, and common noncoding variants at the STAT6 locus associate…”
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International severe asthma registry (ISAR): protocol for a global registry
Published in BMC medical research methodology (14-08-2020)“…Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients…”
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Clinical aspects of using exhaled NO in asthma diagnosis and management
Published in The clinical respiratory journal (01-10-2012)“…Current guidelines recommend tailoring of asthma management according to disease control, which is largely defined by increased symptoms and deterioration in…”
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A sequence variant on 17q21 is associated with age at onset and severity of asthma
Published in European journal of human genetics : EJHG (01-08-2010)“…A sequence variant (rs7216389-T) near the ORMDL3 gene on chromosome 17q21 was recently found to be associated with childhood asthma. We sought to evaluate the…”
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International Severe Asthma Registry
Published in Chest (01-04-2020)“…Regional and/or national severe asthma registries provide valuable country-specific information. However, they are often limited in scope within the broader…”
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A partial loss-of-function variant in STAT6 protects against T2 asthma
Published in Journal of allergy and clinical immunology (16-10-2024)“…Signal Transducer and Activator of Transcription 6 (STAT6) is central to Type 2 (T2) inflammation and common non-coding variants at the STAT6 locus associate…”
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Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort
Published in ERJ open research (2023)“…Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique…”
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