Search Results - "Löser, Heike"

Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma by Quaas, Alexander, Pamuk, Aylin, Klein, Sebastian, Quantius, Jennifer, Rehkaemper, Jan, Barutcu, Atakan G., Rueschoff, Josef, Zander, Thomas, Gebauer, Florian, Hillmer, Axel, Buettner, Reinhard, Schroeder, Wolfgang, Bruns, Christiane J., Löser, Heike, Schoemig-Markiefka, Birgid, Alakus, Hakan

“…Background Tumor-associated neutrophils (TANs) have recently been identified as a relevant component of the tumor microenvironment (TME) in solid tumors…”
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Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains by Klein, Sebastian, Quaas, Alexander, Quantius, Jennifer, Löser, Heike, Meinel, Jörn, Peifer, Martin, Wagner, Steffen, Gattenlöhner, Stefan, Wittekindt, Claus, von Knebel Doeberitz, Magnus, Prigge, Elena-Sophie, Langer, Christine, Noh, Ka-Won, Maltseva, Margaret, Reinhardt, Hans Christian, Büttner, Reinhard, Klussmann, Jens Peter, Wuerdemann, Nora

“…Human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC) is tumorigenic and has been associated with a favorable prognosis compared with…”
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Tumor budding assessed according to the criteria of the International Tumor Budding Consensus Conference determines prognosis in resected esophageal adenocarcinoma by Lohneis, Philipp, Hieggelke, Lena, Gebauer, Florian, Ball, Markus, Bruns, Christiane, Büttner, Reinhard, Löser, Heike, Quaas, Alexander

“…Only few studies examined the prognostic effect of tumor budding in esophageal adenocarcinomas so far. However, different quantification approaches were used,…”
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Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma by Schiffmann, Lars M, Göbel, Heike, Löser, Heike, Schorn, Fabian, Werthenbach, Jan Paul, Fuchs, Hans F, Plum, Patrick S, Bludau, Marc, Zander, Thomas, Schröder, Wolfgang, Bruns, Christiane J, Kashkar, Hamid, Quaas, Alexander, Gebauer, Florian

“…Molecular markers predicting survival in esophageal adenocarcinoma (EAC) are rare. Specifically, in favorable oncologic situations, e.g. nodal negativity or…”
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Integrin beta1 (ITGB1) as a prognostic marker in esophageal adenocarcinoma by Damanakis, Alexander I., Wahler, Isabell, Fuchs, Hans, Löser, Heike, Schröder, Wolfgang, Zander, Thomas, Chon, Seung-Hun, Bruns, Christiane, Quaas, Alexander, Gebauer, Florian

“…Today, individual prognosis in patients with adenocarcinoma of the esophagus (EAC) is based on post-surgical TNM staging and valid biomarkers are still not…”
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Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma by Raters, Verena Maria, Gebauer, Florian, Löser, Heike, Schröder, Wolfgang, Schlösser, Hans Anton, Fuchs, Hans, Bruns, Christiane, Quaas, Alexander, Zander, Thomas

“…Background Staging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity. Therefore, we evaluated…”
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GATA binding protein 6 (GATA6) is co-amplified with PIK3CA in patients with esophageal adenocarcinoma and is linked to neoadjuvant therapy by Plum, Patrick Sven, Löser, Heike, Zander, Thomas, Essakly, Ahlem, Bruns, Christiane J., Hillmer, Axel M., Alakus, Hakan, Schröder, Wolfgang, Büttner, Reinhard, Gebauer, Florian, Quaas, Alexander

“…Purpose Driver mutations are typically absent in esophageal adenocarcinoma (EAC). Mostly, oncogenes are amplified as driving molecular events (including…”
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First reported case of a collision tumor composed of pancreatic adenocarcinoma and retroperitoneal liposarcoma: a case report by Buchner, Denise, Hieggelke, Lena, Löser, Heike, Bruns, Christiane Josephine, Quaas, Alexander, Ghadimi, Markus Philipp Hussein

“…Collision tumors are rare cases with two different tumor entities growing synchronously. While adenocarcinoma of the pancreas is the most common pancreatic…”
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Cell type‐specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics by Krämer, Max, Plum, Patrick S., Velazquez Camacho, Oscar, Folz‐Donahue, Kat, Thelen, Martin, Garcia‐Marquez, Isabel, Wölwer, Christina, Büsker, Sören, Wittig, Jana, Franitza, Marek, Altmüller, Janine, Löser, Heike, Schlößer, Hans, Büttner, Reinhard, Schröder, Wolfgang, Bruns, Christiane J., Alakus, Hakan, Quaas, Alexander, Chon, Seung‐Hun, Hillmer, Axel M.

“…Single‐cell transcriptomics have revolutionized our understanding of the cell composition of tumors and allowed us to identify new subtypes of cells. Despite…”
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CD86 + Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses by Wennhold, Kerstin, Thelen, Martin, Lehmann, Jonas, Schran, Simon, Preugszat, Ella, Garcia-Marquez, Maria, Lechner, Axel, Shimabukuro-Vornhagen, Alexander, Ercanoglu, Meryem S, Klein, Florian, Thangarajah, Fabinshy, Eidt, Sebastian, Löser, Heike, Bruns, Christiane, Quaas, Alexander, von Bergwelt-Baildon, Michael, Schlößer, Hans A

“…The role of B cells in antitumor immunity and their impact on emerging immunotherapies is increasingly gaining attention. B-cell effector functions include not…”
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Predicting the HER2 status in oesophageal cancer from tissue microarrays using convolutional neural networks by Pisula, Juan I., Datta, Rabi R., Valdez, Leandra Börner, Avemarg, Jan-Robert, Jung, Jin-On, Plum, Patrick, Löser, Heike, Lohneis, Philipp, Meuschke, Monique, dos Santos, Daniel Pinto, Gebauer, Florian, Quaas, Alexander, Walch, Axel, Bruns, Christiane J., Lawonn, Kai, Popp, Felix C., Bozek, Katarzyna

“…Background Fast and accurate diagnostics are key for personalised medicine. Particularly in cancer, precise diagnosis is a prerequisite for targeted therapies,…”
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Extensive Analysis of Immunecheckpoint Receptors and Tumor Infiltrating T-Cells with Respect to Their Prognostic Relevance in Esophageal Adenocarcinoma by Gebauer, Florian, Löser, Heike, Schröder, Wolfgang, Zander, Thomas, Fuchs, Hans, Schiffmann, Lars, Alexander, Quaas, Bruns, Christiane

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Vimentin 3, the New Hope, Differentiating RCC versus Oncocytoma by Fries, Jochen W. U., Störkel, Stefan, Gödde, Daniel, Kallinowski, Joachim P., Löser, Heike, Schlosser, Monika, Puetz, Katharina, von Brandenstein, Melanie, Büttner, Reinhard

“…Vimentin is currently used to differentiate between malignant renal carcinomas and benign oncocytomas. Recent reports showing Vimentin positive oncocytomas…”
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Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance by Datta, Rabi R, Schran, Simon, Persa, Oana-Diana, Aguilar, Claire, Thelen, Martin, Lehmann, Jonas, Garcia-Marquez, Maria A, Wennhold, Kerstin, Preugszat, Ella, Zentis, Peter, von Bergwelt-Baildon, Michael S, Quaas, Alexander, Bruns, Christiane J, Kurschat, Christine, Mauch, Cornelia, Löser, Heike, Stippel, Dirk L, Schlößer, Hans A

“…An increased risk to develop cancer is one of the most challenging negative side effects of long-term immunosuppression in organ transplant recipients and…”
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International Tumor Budding Consensus Conference criteria determine the prognosis of oesophageal adenocarcinoma with poor response to neoadjuvant treatment by Lohneis, Philipp, Rohmann, Julia, Gebauer, Florian, Hieggelke, Lena, Bruns, Christiane, Schröder, Wolfgang, Büttner, Reinhard, Löser, Heike, Quaas, Alexander

“…Neoadjuvant therapy regimens followed by surgery represent the current standard treatment of locally advanced oesophageal adenocarcinomas. Tumour regression…”
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Post-transplant malignancies show reduced T-cell abundance and tertiary lymphoid structures as correlates of impaired cancer immunosurveillance by Datta, Rabi R, Schran, Simon, Persa, Oana-Diana, Aguilar, Claire, Thelen, Martin, Lehmann, Jonas, García-Marquez, Maria A, Wennhold, Kerstin, Preugszat, Ella, Zentis, Peter, von Bergwelt-Baildon, Michael S, Quaas, Alexander, Bruns, Christiane J, Kurschat, Christine, Mauch, Cornelia, Löser, Heike, Stippel, Dirk L, Schlößer, Hans A

“…An increased risk to develop cancer is one of the most challenging negative side effects of long-term immunosuppression in organ transplant recipients and…”
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White-Light or Narrow-Band Imaging Colonoscopy in Surveillance of Ulcerative Colitis: A Prospective Multicenter Study by Leifeld, Ludger, Rogler, Gerhard, Stallmach, Andreas, Schmidt, Carsten, Zuber-Jerger, Ina, Hartmann, Franz, Plauth, Mathias, Drabik, Attyla, Hofstädter, Ferdinand, Dienes, Hans Peter, Kruis, Wolfgang

“…Background & Aims Early detection of neoplastic lesions is essential in patients with long-standing ulcerative colitis but the best technique of colonoscopy…”
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Expression of Immune Checkpoint Regulators IDO, VISTA, LAG3, and TIM3 in Resected Pancreatic Ductal Adenocarcinoma by Popp, Felix C, Capino, Ingracia, Bartels, Joana, Damanakis, Alexander, Li, Jiahui, Datta, Rabi R, Löser, Heike, Zhao, Yue, Quaas, Alexander, Lohneis, Philipp, Bruns, Christiane J, On Behalf Of The Pancalyze Study Group

“…Pancreatic cancer features elaborate mechanisms of immune evasion. The potential of new immune molecules was explored to restore the antitumor immune response…”
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PS02.197: UPREGULATION OF IMP3 HAS A NEGATIVE PROGNOSTIC IMPACT IN EARLY INVASIVE ESOPHAGEAL ADENOCARCINOMA by Plum, Patrick, Ulase, Dita, Chon, Seung-Hun, Berlth, Felix, Zander, Thomas, Alakus, Hakan, Bollschweiler, Elfriede, Hölscher, Arnulf, Bruns, Christiane, Quaas, Alexander, Löser, Heike

“…Abstract Background Despite improvements in perioperative treatments, the overall survival of patients with esophageal adenocarcinoma (EAC) remains low. In…”
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Aldo-keto reductase family 1 member B10 (AKR1B10), a metabolic target for gemcitabine resistance and metastasis of pancreatic cancer: Implications based on cancer stem cells and niche by Li, Jiahui, Lohmann, Judith, Popp, Felix, Popp, Marie, Wartmann, Thomas, Renner, Andrea, Kalinski, Thomas, Quaas, Alexander, Qin, Jie, Zhao, Jiangang, Löser, Heike, Knösel, Thomas, Altendorf-Hofmann, Annelore, Schlößer, Hans A., Jauch, Karl Walter, Nelson, Peter J., Dong, Qiong Zhu, Bruns, Christiane, Zhao, Yue

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