Search Results - "Löschmann, Peter‐A."

Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia by Richter, Angelika, Löschmann, Peter‐A, Löscher, Wolfgang

“…In a hamster model (genetic symbol dtsz) of primary paroxysmal non‐kinesiogenic dystonic choreoathetosis, recent studies have shown beneficial effects of…”
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Induction of Nitric Oxide Synthase and Nitric Oxide‐Mediated Apoptosis in Neuronal PC12 Cells After Stimulation with Tumor Necrosis FActor‐α/Lipopolysaccharide by Heneka, Michael T., Löschmann, Peter‐A., Gleichmann, Marc, Weller, Michael, Schulz, Jörg B., Wüllner, Ullrich, Klockgether, Thomas

“…: Exposure of neuronal PC12 cells, differentiated by nerve growth factor, to tumor necrosis factor‐α (TNF‐α) and bacterial lipopolysaccharide (LPS) resulted in…”
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Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets by LÖSCHMANN, P.-A, SMITH, L. A, LANGE, K. W, JÄHNIG, P, JENNER, P, MARSDEN, C. D

“…The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets. Both the…”
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Cooperative Interception of Neuronal Apoptosis by BCL‐2 and BAG‐1 Expression: Prevention of Caspase Activation and Reduced Production of Reactive Oxygen Species by Schulz, Jörg B., Bremen, Dirk, Reed, John C., Lommatzsch, Jürgen, Takayama, Shinichi, Wüllner, Ullrich, Löschmann, Peter‐A., Klockgether, Thomas, Weller, Michael

“…: Neuronally differentiated PC12 cells undergo synchronous apoptosis when deprived of nerve growth factor (NGF). Here we show that NGF withdrawal induces…”
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Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia by Schulz, J B, Weller, M, Matthews, R T, Heneka, M T, Groscurth, P, Martinou, J C, Lommatzsch, J, von Coelln, R, Wüllner, U, Löschmann, P A, Beal, M F, Dichgans, J, Klockgether, T

“…In rats, striatal histotoxic hypoxic lesions produced by the mitochondrial toxin malonate resemble those of focal cerebral ischemia. Intrastriatal injections…”
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Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets by LOSCHMANN, P.-A, SMITH, L. A, LANGE, K. W, JAEHNIG, P, JENNER, P, MARSDEN, C. D

“…In normal common marmosets administration of the D-1/D-2 agonist apomorphine or the selective D-2 agonist quinpirole caused a dose-dependent increase in motor…”
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The NMDA antagonist memantine impairs classical eyeblink conditioning in humans by Schugens, Markus M, Egerter, Ralf, Daum, Irene, Schepelmann, Karsten, Klockgether, Thomas, Löschmann, Peter-A

“…The present study investigated the effects of a single oral dose (30 mg) of the non-competitive N-methyl- d-aspartate (NMDA) receptor antagonist memantine on…”
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Synthesis and biological effects of NO in malignant glioma cells : modulation by cytokines including CD95l and TGF-β, dexamethasone, and p53 gene transfer by RIEGER, J, STÄNDER, M, LÖSCHMANN, P. A, HENEKA, M, DICHGANS, J, KLOCKGETHER, T, WELLER, M

“…Nitric oxide (NO) is thought to play an important role in neurotransmission, inflammation, and regulation of cell death in the mammalian brain. Here, we…”
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Temporal, regional, and cell-specific changes of iNOS expression after intrastriatal microinjection of interferon gamma and bacterial lipopolysaccharide by Heneka, Michael T., Dumitrescu, Lucia, Löschmann, Peter-A., Wüllner, Ulrich, Klockgether, Thomas

“…Here we study expression of the inducible isoform of nitric oxide synthases after intrastriatal microinjection of interferon-γ and bacterial lipopolysaccharide…”
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The AMPA receptor antagonist NBQX exerts antidystonic effects in an animal model of idiopathic dystonia by Richter, A, Löscher, W, Löschmann, P A

“…The effects of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) antagonist NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline) were…”
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Stereoselective reversal of MPTP-induced parkinsonism in the marmoset after dermal application of N-0437 by Löschmann, P A, Chong, P N, Nomoto, M, Tepper, P G, Horn, A S, Jenner, P, Marsden, C D

“…The selective dopamine D-2 receptor agonist N-0437 produced a rapid and dose-dependent reversal of motor deficits lasting 90-120 min following i.p. or oral…”
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Terguride stimulates locomotor activity at 2 months but not 10 months after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets by Lange, K W, Löschmann, P A, Wachtel, H, Horowski, R, Jähnig, P, Jenner, P, Marsden, C D

“…The mixed dopamine (DA) agonist/antagonist terguride acts as a DA antagonist on normosensitive receptors but shows DA agonistic properties at supersensitive DA…”
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Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat by Heneka, M T, Löschmann, P A, Osswald, H

“…Sepsis and its complications, hypotension, shock, and multiorgan failure continue to represent a significant cause of mortality among hospitalized patients,…”
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The non-competitive N-methyl- d-aspartate-antagonist memantine does not affect segmental mono- and polysynaptic reflexes in man by Schepelmann, Karsten, Schugens, Markus M., Löschmann, Peter A., Klockgether, Thomas, Dichgans, Johannes

“…Studies in rats have shown that the polysynaptic flexor reflex (FR) but not the monosynaptic reflexes are affected by N-methyl- d-aspartate (NMDA) receptor…”
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Substantia nigra regulates action of antiepileptic drugs by Turski, L, Andrews, J S, Löschmann, P A, Bressler, K, Bortolotto, Z A, Calderazzo-Filho, L S, Cavalheiro, E A

“…The cholinergic agonist pilocarpine triggers sustained limbic seizures in rodents. Pilocarpine seizures were blocked by systemic administration of…”
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Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram by WACHTEL, H, LÖSCHMANN, P.-A

“…Forskolin, a direct activator of the catalytic subunit of adenylate cyclase (AC), and the cyclic nucleotide analogs dibutyryl cAMP (dBcAMP), 8-bromo cAMP…”
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