Search Results - "Lönnerholm, G"

The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial by Zachariadis, V, Gauffin, F, Kuchinskaya, E, Heyman, M, Schoumans, J, Blennow, E, Gustafsson, B, Barbany, G, Golovleva, I, Ehrencrona, H, Cavelier, L, Palmqvist, L, Lönnerholm, G, Nordenskjöld, M, Johansson, B, Forestier, E, Nordgren, A

“…The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes…”
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Digital gene expression profiling of primary acute lymphoblastic leukemia cells by Nordlund, J, Kiialainen, A, Karlberg, O, Berglund, E C, Göransson-Kultima, H, Sønderkær, M, Nielsen, K L, Gustafsson, M G, Behrendtz, M, Forestier, E, Perkkiö, M, Söderhäll, S, Lönnerholm, G, Syvänen, A-C

“…We determined the genome-wide digital gene expression (DGE) profiles of primary acute lymphoblastic leukemia (ALL) cells from 21 patients taking advantage of…”
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CD27 expression and its association with clinical outcome in children and adults with pro-B acute lymphoblastic leukemia by Chen, D, Gerasimčik, N, Camponeschi, A, Tan, Y, Wu, Q, Brynjolfsson, S, Zheng, J, Abrahamsson, J, Nordlund, J, Lönnerholm, G, Fogelstrand, L, Mårtensson, I-L

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Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia by Ivanov Öfverholm, Ingegerd, Zachariadis, Vasilios, Taylan, Fulya, Marincevic-Zuniga, Yanara, Tran, Anh Nhi, Saft, Leonie, Nilsson, Daniel, Syvänen, Ann-Christine, Lönnerholm, Gudmar, Harila-Saari, Arja, Nordenskjöld, Magnus, Heyman, Mats, Nordgren, Ann, Nordlund, Jessica, Barbany, Gisela

“…Intrachromosomal amplification of chromosome 21 (iAMP21) is a cytogenetic subtype associated with relapse and poor prognosis in pediatric B-cell precursor…”
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Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome by Norén-Nyström, U, Roos, G, Bergh, A, Botling, J, Lönnerholm, G, Porwit, A, Heyman, M, Forestier, E

“…We retrospectively evaluated reticulin fiber density (RFD) in 166 diagnostic bone marrow (BM) biopsies and 62 biopsies obtained at treatment day 29 from…”
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Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids by Lönnerholm, G, Nordgren, A, Frost, B-M, Jonsson, O G, Kanerva, J, Nygaard, R, Schmiegelow, K, Larsson, R, Forestier, E

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Renal function after autologous bone marrow transplantation in children: a long-term prospective study by FRISK, P, BRATTEBY, L. E, CARLSON, K, LÖNNERHOLM, G

“…We measured glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and the concentrating capacity of the kidneys in children after autologous…”
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Vincristine pharmacokinetics is related to clinical outcome in children with standard risk acute lymphoblastic leukemia by Lönnerholm, Gudmar, Frost, Britt‐Marie, Abrahamsson, Jonas, Behrendtz, Mikael, Castor, Anders, Forestier, Erik, Heyman, Mats, Uges, Donald R. A., de Graaf, Siebold S. N.

“…Summary Vincristine is a key drug in the treatment of childhood and adult acute lymphoblastic leukemia (ALL), and many other childhood malignancies. Despite…”
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Dendritic Cell Regeneration in the Bone Marrow of Children Treated for Acute Lymphoblastic Leukaemia by Laane, E, Björklund, E, Mazur, J, Lönnerholm, G, Söderhäll, S, Porwit, A

“…Dendritic cells (DC) play a pivotal role in coordinating functions of the immune system. Little is known about DC levels in the bone marrow (BM) of patients…”
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Renal function after autologous bone marrow transplantation in children: a long-term prospective study by Frisk, P, Bratteby, L E, Carlson, K, Lonnerholm, G

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No Disadvantage in Outcome of Using Matched Unrelated Donors as Compared With Matched Sibling Donors for Bone Marrow Transplantation in Children With Acute Lymphoblastic Leukemia in Second Remission by Saarinen-Pihkala, U M, Gustafsson, G, Ringdén, O, Heilmann, C, Glomstein, A, Lönnerholm, G, Abrahamsson, J, Bekassy, A N, Schroeder, H, Mellander, L

“…We evaluated the outcome of children with acute lymphoblastic leukemia (ALL) in second remission (2CR), comparing bone marrow transplantation (BMT) using…”
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High-dose methotrexate: on the relationship of methotrexate elimination time vs renal function and serum methotrexate levels in 1164 courses in 264 Swedish children with acute lymphoblastic leukaemia (ALL) by SKÄRBY, T, JÖNSSON, P, HJORTH, L, BEHRENTZ, M, BJÖRK, O, FORESTIER, E, JARFELT, M, LÖNNERHOLM, G, HÖGLUND, P

“…The objectives of the present study were to determine the relationship between methotrexate (MTX) elimination time and various aspects of renal function and to…”
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Cellular drug sensitivity in MLL‐rearranged childhood acute leukaemia is correlated to partner genes and cell lineage by Palle, J., Frost, B. M., Forestier, E., Gustafsson, G., Nygren, P., Hellebostad, M., Jonsson, O. G., Kanerva, J., Schmiegelow, K., Larsson, R., Lönnerholm, G.

“…Summary Rearrangements in the 11q23 region, the site of the mixed lineage leukaemia (MLL) gene, are found in both childhood acute myeloid (AML) and…”
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Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia by Frost, B M, Forestier, E, Gustafsson, G, Nygren, P, Hellebostad, M, Jonmundsson, G, Kanerva, J, Schmiegelow, K, Larsson, R, Lönnerholm, G

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Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia by Frost, Britt-Marie, Forestier, Erik, Gustafsson, Göran, Nygren, Peter, Hellebostad, Marit, Jonsson, Olafur G., Kanerva, Jukka, Schmiegelow, Kjeld, Larsson, Rolf, Lönnerholm, Gudmar

“…The t(12;21) (p13;q22) translocation resulting in ETV6/RUNX1 (previously named TEL/AML1) gene fusion is present in about 25% of children with precursor…”
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Cellular cytotoxic drug sensitivity in children with acute leukemia and Down's syndrome: an explanation to differences in clinical outcome? by Frost, B M, Gustafsson, G, Larsson, R, Nygren, P, Lönnerholm, G

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Increased in vitro cellular drug resistance is related to poor outcome in high‐risk childhood acute lymphoblastic leukaemia by Frost, Britt‐Marie, Nygren, Peter, Gustafsson, Göran, Forestier, Erik, Jonsson, Olafur G., Kanerva, Jukka, Nygaard, Randi, Schmiegelow, Kjeld, Larsson, Rolf, Lönnerholm, Gudmar

“…We determined the in vitro cellular drug resistance in 370 children with newly diagnosed acute lymphoblastic leukaemia (ALL). The resistance to each of 10…”
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In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia by Frost, B-M, Lönnerholm, G, Nygren, P, Larsson, R, Lindhagen, E

“…CHS 828, a pyridyl cyanoguanidine, is a new drug candidate now in phase I/II trials, that has shown promising anticancer activity in experimental tumor models…”
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Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles by Marincevic-Zuniga, Yanara, Dahlberg, Johan, Nilsson, Sara, Raine, Amanda, Nystedt, Sara, Lindqvist, Carl Mårten, Berglund, Eva C, Abrahamsson, Jonas, Cavelier, Lucia, Forestier, Erik, Heyman, Mats, Lönnerholm, Gudmar, Nordlund, Jessica, Syvänen, Ann-Christine

“…Structural chromosomal rearrangements that lead to expressed fusion genes are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed…”
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Immunity to Poliovirus and Immunization with Inactivated Poliovirus Vaccine After Autologous Bone Marrow Transplantation by Pauksen, K., Hammarstrom, V., Ljungman, P., Sjolin, J., Oberg, G., Lonnerholm, G., Magnius, L., Simonsson, B.

“…Titers of antibody to poliovirus in 102 patients were determined with a sensitive neutralization assay before and 1 year after autologous bone marrow…”
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