Search Results - "Löhr, H F"

Durability of HBeAg seroconversion following antiviral therapy for chronic hepatitis B: relation to type of therapy and pretreatment serum hepatitis B virus DNA and alanine aminotransferase by van Nunen, A B, Hansen, B E, Suh, D J, Löhr, H F, Chemello, L, Fontaine, H, Heathcote, J, Song, B C, Janssen, H L A, de Man, R A, Schalm, S W

“…Background and aims: Interferon (IFN) induced hepatitis B e antigen (HBeAg) seroconversion is durable in 80–90% of chronic hepatitis B patients. Preliminary…”
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Bile duct epithelia as target cells in primary biliary cirrhosis and primary sclerosing cholangitis by DIENES, H. P, LOHSE, A. W, GERKEN, G, SCHIRMACHER, P, GALLATI, H, LÖHR, H. F, MEYER ZUM BÜSCHENFELDE, K. H

“…Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are chronic autoimmune-mediated diseases of the biliary tree, resulting in a loss of…”
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HLA-DRB11301 AND 1302 protect against chronic hepatitis B by Höhler, Thomas, Gerken, Guido, Notghi, Arman, Lubjuhn, Roswitha, Taheri, Homa, Protzer, Ulrike, Löhr, Hans F., Schneider, Peter M., Meyer zum Büschenfelde, Karl-H., Rittner, Christian

“…Background/Aims: The outcome of acute hepatitis B infection may be influenced by host factors like the major histocompatibility complex (MHC). We have…”
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Regulation of the neutralizing anti‐hepatitis B surface (HBs) antibody response in vitro in HBs vaccine recipients and patients with acute or chronic hepatitis B virus (HBV) infection by BÖCHER, W. O., HERZOG‐HAUFF, S., HERR, W., HEERMANN, K., GERKEN, G., MEYER ZUM BÜSCHENFELDE, K.‐H., LÖHR, H. F.

“…Antibodies directed to the HBs antigen indicate viral clearance and the development of life‐long immunity in patients that recovered from HBV infection. In HBs…”
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Low Frequency of Cytotoxic Liver-Infiltrating T Lymphocytes Specific for Endogenous Processed Surface and Core Proteins in Chronic Hepatitis B by Löhr, H. F., Gerken, G., Schlicht, H.-J., zum Büschenfelde, K.-H. Meyer, Fleischer, B.

“…To investigate the role of hepatitis Bvirus (HBV)-specific CD8+ T cells in chronic hepatitis B, the lytic activity of peripheral blood mononuclear cells (PBMC)…”
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Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B – restoration by exogenous interleukin‐12 by LÖHR, H. F., PINGEL, S., BÖCHER, W. O., BERNHARD, H., HERZOG‐HAUFF, S., ROSE‐JOHN, S.

“…SUMMARY Insufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral…”
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Cellular and humoral immune responses induced by intradermal or intramuscular vaccination with the major hepatitis B surface antigen by Rahman, Fareed, Dahmen, Anja, Herzog‐Hauff, Sabine, Böcher, Wulf O., Galle, Peter R., Löhr, Hanns F.

“…The vaccination route may influence the success of immunization against pathogens. The conventional intramuscular (i.m.) application of a vaccine containing…”
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HBV‐specific immune defect in chronic hepatitis B (CHB) is correlated with a dysregulation of pro‐ and anti‐inflammatory cytokines by SCHLAAK, J. F, TULLY, G, LÖHR, H. F, GERKEN, G, BÜSCHENFELDE, K.-H. M. Z

“…The aim of this study was to examine the immunomodulating effects of rhIL‐12 on the immune response induced by hepatitis B virus (HBV) antigens in clinical…”
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Individual and Common Antigen‐Recognition Sites of Liver‐Derived T Cells in Patients with Autoimmune Hepatitis by Löhr, H. F., Pingel, S., Weyer, S., Fritz, T., Galle, P. R.

“…Autoimmune hepatitis (AIH) is characterized by dense T‐cell infiltrations in the liver tissue, but little is known how T cells influence the pathogenesis. To…”
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Kinetics of hepatitis B surface antigen–specific immune responses in acute and chronic hepatitis B or After HBs vaccination: Stimulation of the in vitro antibody response by interferon gamma by Böcher, Wulf Otto, Herzog‐Hauff, Sabine, Schlaak, Jörg, Meyer zum Büschenfelde, Karl‐Hermann, Löhr, Hanns Friedrich

“…Because cellular and humoral immune responses against the hepatitis B virus (HBV) surface antigen (HBs) might be crucial to overcome HBV infection,…”
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Quantitative analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in interferon-α-treated patients with chronic hepatitis C by Hempel, Gerd, Galle, Peter R., Löhr, Hanns F.

“…This study aimed to characterise the immune mechanisms relevant to viral clearance in interferon (IFN)‐α‐treated chronic hepatitis C virus (HCV) infection…”
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Reduced hepatitis B virus surface antigen–specific Th1 helper cell frequency of chronic HBV carriers is associated with a failure to produce antigen‐specific antibodies in the Trimera mouse by Böcher, Wulf Otto, Galun, Eithan, Marcus, Hadar, Daudi, Nili, Terkieltaub, Dov, Shouval, Daniel, Löhr, Hanns Friedrich, Reisner, Yair

“…In chronic hepatitis B virus (HBV) infection weak antiviral immune responses are associated with viral persistence. We studied possible immune deficits…”
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The cellular immune responses induced in the follow-up of interferon-α treated patients with chronic hepatitis C may determine the therapy outcome by Löhr, Hanns F., Gerken, Guido, Roth, Michael, Weyer, Sandra, Schalaak, Jörg F., Büschenfelder, Karl-Hermann Meyer zum

“…Background/Aims: To study whether the host's immune response determines viral clearance in chronic hepatitis C, virological markers and antigen-specific T cell…”
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Relation between autoimmune liver diseases and viral hepatitis: clinical and serological characteristics in 859 patients by Lohse, A W, Gerken, G, Mohr, H, Löhr, H F, Treichel, U, Dienes, H P, Meyer zum Büschenfelde, K H

“…An etiopathological link between hepatitis virus infection and autoimmune liver disease, in particular autoimmune hepatitis has been suggested. In some…”
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The presence of high amounts of HBV-DNA in serum is associated with suppressed costimulatory effects of interleukin 12 on HBV-induced immune response by Schlaak, Jörg F, Tully, Glenn, Löhr, Hanns F, Gerken, Guido, Büschenfelde, Karl-Hermann Meyer zum

“…Background/Aims: The aim of this study was to examine the influence of the viral load on costimulatory effects of rhIL-12 on the hepatitis B virus…”
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Interleukin-2 has no additional therapeutic efficacy in the retreatment of patients with chronic hepatitis C that had not responded to interferon-α plus ribavirin by Barreiros, A. P., Schlaak, J. F., Gerken, G., Galle, P. R., Löhr, H. F.

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Antigen-independent in vitro expansion of T cells does not affect the T cell receptor Vβ repertoire by ARENZ, M, HERZOG-HAUFF, S, MEYER ZUM BÜSCHENFELDE, K.-H, LÖHR, H. F

“…Analysis of the variable chains (V alpha/V beta) of the specific T cell receptor (TCR) of organ-infiltrating T cells may provide further insights into the…”
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Long-term survival in a patient with Rosai-Dorfman disease treated with interferon-α by Löhr, H.F., Gödderz, W., Wölfe, T., Heike, M., Knuth, A., Büschenfelde, K.-H.Meyer zum, Dippold, W.

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HCV replication in mononuclear cells stimulates anti-HCV-secreting B cells and reflects nonresponsiveness to interferon-alpha by Löhr, H F, Goergen, B, Meyer zum Büschenfelde, K H, Gerken, G

“…Recently, it was demonstrated in chronic hepatitis C that the release of IgG and IgM anti-HCV antibodies by mononuclear cells (PBMCs) correlated with…”
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Interleukin 12 enhances deficient HCV-antigen-induced Th1-type immune response of peripheral blood mononuclear cells by Schlaak, Jörg F., Pitz, Tanja, Löhr, Hanns F., zum Büschenfelde, Karl-Hermann Meyer, Gerken, Guido

“…The aim of this study was to examine the possible immunomodulating effects of rhIL‐12 on the immune response induced by different hepatitis C virus (HCV)…”
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