Search Results - "Löck, Steffen"

Assessing robustness of radiomic features by image perturbation by Zwanenburg, Alex, Leger, Stefan, Agolli, Linda, Pilz, Karoline, Troost, Esther G. C., Richter, Christian, Löck, Steffen

“…Image features need to be robust against differences in positioning, acquisition and segmentation to ensure reproducibility. Radiomic models that only include…”
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The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping by Zwanenburg, Alex, Vallières, Martin, Abdalah, Mahmoud A, Aerts, Hugo J W L, Andrearczyk, Vincent, Apte, Aditya, Ashrafinia, Saeed, Bakas, Spyridon, Beukinga, Roelof J, Boellaard, Ronald, Bogowicz, Marta, Boldrini, Luca, Buvat, Irène, Cook, Gary J R, Davatzikos, Christos, Depeursinge, Adrien, Desseroit, Marie-Charlotte, Dinapoli, Nicola, Dinh, Cuong Viet, Echegaray, Sebastian, El Naqa, Issam, Fedorov, Andriy Y, Gatta, Roberto, Gillies, Robert J, Goh, Vicky, Götz, Michael, Guckenberger, Matthias, Ha, Sung Min, Hatt, Mathieu, Isensee, Fabian, Lambin, Philippe, Leger, Stefan, Leijenaar, Ralph T H, Lenkowicz, Jacopo, Lippert, Fiona, Losnegård, Are, Maier-Hein, Klaus H, Morin, Olivier, Müller, Henning, Napel, Sandy, Nioche, Christophe, Orlhac, Fanny, Pati, Sarthak, Pfaehler, Elisabeth A G, Rahmim, Arman, Rao, Arvind U K, Scherer, Jonas, Siddique, Muhammad Musib, Sijtsema, Nanna M, Socarras Fernandez, Jairo, Spezi, Emiliano, Steenbakkers, Roel J H M, Tanadini-Lang, Stephanie, Thorwarth, Daniela, Troost, Esther G C, Upadhaya, Taman, Valentini, Vincenzo, van Dijk, Lisanne V, van Griethuysen, Joost, van Velden, Floris H P, Whybra, Philip, Richter, Christian, Löck, Steffen

“…Background Radiomic features may quantify characteristics present in medical imaging. However, the lack of standardized definitions and validated reference…”
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Identification of Patient Benefit From Proton Therapy for Advanced Head and Neck Cancer Patients Based on Individual and Subgroup Normal Tissue Complication Probability Analysis by Jakobi, Annika, MSc, Bandurska-Luque, Anna, MD, Stützer, Kristin, PhD, Haase, Robert, Dipl Inf (FH), Löck, Steffen, PhD, Wack, Linda-Jacqueline, MSc, Mönnich, David, PhD, Thorwarth, Daniela, PhD, Perez, Damien, MSc, Lühr, Armin, PhD, Zips, Daniel, MD, Krause, Mechthild, MD, PhD, Baumann, Michael, MD, PhD, Perrin, Rosalind, PhD, Richter, Christian, PhD

“…Purpose The purpose of this study was to determine, by treatment plan comparison along with normal tissue complication probability (NTCP) modeling, whether a…”
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Can Local Ablative Radiotherapy Revert Castration-resistant Prostate Cancer to an Earlier Stage of Disease? by Lohaus, Fabian, Zöphel, Klaus, Löck, Steffen, Wirth, Manfred, Kotzerke, Jörg, Krause, Mechthild, Baumann, Michael, Troost, Esther G.C., Hölscher, Tobias

“…In prostate cancer, disease progression after primary treatment and subsequent androgen deprivation therapy is common. Intensification of systemic treatment is…”
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Radiomics-based tumor phenotype determination based on medical imaging and tumor microenvironment in a preclinical setting by Müller, Johannes, Leger, Stefan, Zwanenburg, Alex, Suckert, Theresa, Lühr, Armin, Beyreuther, Elke, von Neubeck, Cläre, Krause, Mechthild, Löck, Steffen, Dietrich, Antje, Bütof, Rebecca

“…•Correlation of MRI-derived texture features with tumor microenvironment parameters.•Examination of a heterogeneous cohort with different treatment- and beam…”
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Regular-to-chaotic tunneling rates: from the quantum to the semiclassical regime by Löck, Steffen, Bäcker, Arnd, Ketzmerick, Roland, Schlagheck, Peter

“…We derive a prediction of dynamical tunneling rates from regular to chaotic phase-space regions combining the direct regular-to-chaotic tunneling mechanism in…”
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Multivariate statistical modelling to improve particle treatment verification: Implications for prompt gamma-ray timing by Schellhammer, Sonja M., Wiedkamp , Julia, Löck , Steffen, Kögler, Toni

“…We present an improved method for in-vivo proton range verification by prompt gamma-ray timing based on multivariate statistical modelling. To this end, prompt…”
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Value of PET imaging for radiation therapy by Lapa, Constantin, Nestle, Ursula, Albert, Nathalie L., Baues, Christian, Beer, Ambros, Buck, Andreas, Budach, Volker, Bütof, Rebecca, Combs, Stephanie E., Derlin, Thorsten, Eiber, Matthias, Fendler, Wolfgang P., Furth, Christian, Gani, Cihan, Gkika, Eleni, Grosu, Anca-L., Henkenberens, Christoph, Ilhan, Harun, Löck, Steffen, Marnitz-Schulze, Simone, Miederer, Matthias, Mix, Michael, Nicolay, Nils H., Niyazi, Maximilian, Pöttgen, Christoph, Rödel, Claus M., Schatka, Imke, Schwarzenboeck, Sarah M., Todica, Andrei S., Weber, Wolfgang, Wegen, Simone, Wiegel, Thomas, Zamboglou, Constantinos, Zips, Daniel, Zöphel, Klaus, Zschaeck, Sebastian, Thorwarth, Daniela, Troost, Esther G. C.

“…This comprehensive review written by experts in their field gives an overview on the current status of incorporating positron emission tomography (PET) into…”
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Comparative analysis of radiomics and deep-learning algorithms for survival prediction in hepatocellular carcinoma by Schön, Felix, Kieslich, Aaron, Nebelung, Heiner, Riediger, Carina, Hoffmann, Ralf-Thorsten, Zwanenburg, Alex, Löck, Steffen, Kühn, Jens-Peter

“…To examine the comparative robustness of computed tomography (CT)-based conventional radiomics and deep-learning convolutional neural networks (CNN) to predict…”
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Radiomics for residual tumour detection and prognosis in newly diagnosed glioblastoma based on postoperative [11C] methionine PET and T1c-w MRI by Shahzadi, Iram, Seidlitz, Annekatrin, Beuthien-Baumann, Bettina, Zwanenburg, Alex, Platzek, Ivan, Kotzerke, Jörg, Baumann, Michael, Krause, Mechthild, Troost, Esther G. C., Löck, Steffen

“…Personalized treatment strategies based on non-invasive biomarkers have potential to improve patient management in patients with newly diagnosed glioblastoma…”
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Prediction of clinically relevant postoperative pancreatic fistula using radiomic features and preoperative data by Bhasker, Nithya, Kolbinger, Fiona R., Skorobohach, Nadiia, Zwanenburg, Alex, Löck, Steffen, Weitz, Jürgen, Hoffmann, Ralf-Thorsten, Distler, Marius, Speidel, Stefanie, Leger, Stefan, Kühn, Jens-Peter

“…Clinically relevant postoperative pancreatic fistula (CR-POPF) can significantly affect the treatment course and outcome in pancreatic cancer patients…”
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Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models by Shahzadi, Iram, Zwanenburg, Alex, Lattermann, Annika, Linge, Annett, Baldus, Christian, Peeken, Jan C., Combs, Stephanie E., Diefenhardt, Markus, Rödel, Claus, Kirste, Simon, Grosu, Anca-Ligia, Baumann, Michael, Krause, Mechthild, Troost, Esther G. C., Löck, Steffen

“…Radiomics analyses commonly apply imaging features of different complexity for the prediction of the endpoint of interest. However, the prognostic value of…”
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HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG) by Lohaus, Fabian, Linge, Annett, Tinhofer, Inge, Budach, Volker, Gkika, Eleni, Stuschke, Martin, Balermpas, Panagiotis, Rödel, Claus, Avlar, Melanie, Grosu, Anca-Ligia, Abdollahi, Amir, Debus, Jürgen, Bayer, Christine, Belka, Claus, Pigorsch, Steffi, Combs, Stephanie E, Mönnich, David, Zips, Daniel, von Neubeck, Cläre, Baretton, Gustavo B, Löck, Steffen, Thames, Howard D, Krause, Mechthild, Baumann, Michael

“…Abstract Objective To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received…”
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Type I conventional dendritic cells and CD8 + T cells predict favorable clinical outcome of head and neck squamous cell carcinoma patients by Kirchner, Johanna, Plesca, Ioana, Rothe, Rebecca, Resag, Antonia, Löck, Steffen, Benešová, Iva, Rupp, Luise, Linge, Annett, Wehner, Rebekka, Krause, Mechthild, Schmitz, Marc

“…Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumor entities worldwide, with human papillomavirus (HPV) infection contributing to…”
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Prognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts by Koi, Lydia, Bitto, Verena, Weise, Corina, Möbius, Lisa, Linge, Annett, Löck, Steffen, Yaromina, Ala, Besso, María José, Valentini, Chiara, Pfeifer, Manuel, Overgaard, Jens, Zips, Daniel, Kurth, Ina, Krause, Mechthild, Baumann, Michael

“…Abstract Background Tumor hypoxia is associated with resistance to radiotherapy and chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole,…”
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Specific requirements for translation of biological research into clinical radiation oncology by Krause, Mechthild, Alsner, Jan, Linge, Annett, Bütof, Rebecca, Löck, Steffen, Bristow, Rob

“…Radiotherapy has been optimized over the last decades not only through technological advances, but also through the translation of biological knowledge into…”
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Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy by Cordes, Nils, Ney, Michael, Beleites, Thomas, Aust, Daniela, Baretton, Gustavo, Thames, Howard, Baumann, Michael, Krause, Mechthild, Löck, Steffen, Appold, Steffen

“…This retrospective study evaluated the expression of β1 integrins and associated proteins as prognostic markers for primary radio(chemo)therapy outcome of…”
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The dresden platform is a research hub for ultra-high dose rate radiobiology by Metzkes-Ng, Josefine, Brack, Florian-Emanuel, Kroll, Florian, Bernert, Constantin, Bock, Stefan, Bodenstein, Elisabeth, Brand, Michael, Cowan, Thomas E., Gebhardt, René, Hans, Stefan, Helbig, Uwe, Horst, Felix, Jansen, Jeannette, Kraft, Stephan D., Krause, Mechthild, Leßmann, Elisabeth, Löck, Steffen, Pawelke, Jörg, Püschel, Thomas, Reimold, Marvin, Rehwald, Martin, Richter, Christian, Schlenvoigt, Hans-Peter, Schramm, Ulrich, Schürer, Michael, Seco, Joao, Szabó, Emília Rita, Umlandt, Marvin E. P., Zeil, Karl, Ziegler, Tim, Beyreuther, Elke

“…The recently observed FLASH effect describes the observation of normal tissue protection by ultra-high dose rates (UHDR), or dose delivery in a fraction of a…”
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Heterogeneity of γH2AX Foci Increases in Ex Vivo Biopsies Relative to In Vivo Tumors by Rassamegevanon, Treewut, Löck, Steffen, Baumann, Michael, Krause, Mechthild, von Neubeck, Cläre

“…The biomarker for DNA double stand breaks, gammaH2AX (γH2AX), holds a high potential as an intrinsic radiosensitivity predictor of tumors in clinical practice…”
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Hybrid treatment verification based on prompt gamma rays and fast neutrons: multivariate modelling for proton range determination by Schellhammer, Sonja M., Meric, Ilker, Löck, Steffen, Kögler, Toni

“…Robust and fast in vivo treatment verification is expected to increase the clinical efficacy of proton therapy. The combined detection of prompt gamma rays and…”
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