Search Results - "Löchte, Sara"

Single Cell GFP-Trap Reveals Stoichiometry and Dynamics of Cytosolic Protein Complexes by Wedeking, Tim, Löchte, Sara, Richter, Christian P, Bhagawati, Maniraj, Piehler, Jacob, You, Changjiang

“…We developed in situ single cell pull-down (SiCPull) of GFP-tagged protein complexes based on micropatterned functionalized surface architectures. Cells…”
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Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy by Yang, Xinbo, Nishimiya, Daisuke, Löchte, Sara, Jude, Kevin M., Borowska, Marta, Savvides, Christina S., Dougan, Michael, Su, Leon, Zhao, Xiang, Piehler, Jacob, Garcia, K. Christopher

“…Monoclonal antibodies (Abs) that recognize major histocompatability complex (MHC)-presented tumor antigens in a manner similar to T cell receptors (TCRs) have…”
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations by Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie A, Winkelmann, Hauke, Löchte, Sara, Stanly, Tess A, Pulgar Prieto, Katiuska D, Poojari, Chetan, Sharma, Vivek, Richter, Christian P, Kurre, Rainer, Hubbard, Stevan R, Garcia, K Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian S, Piehler, Jacob

“…Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are activated by ligand-induced conformational changes. We quantified the…”
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Dynamic Submicroscopic Signaling Zones Revealed by Pair Correlation Tracking and Localization Microscopy by You, Changjiang, Richter, Christian P., Löchte, Sara, Wilmes, Stephan, Piehler, Jacob

“…Unraveling the spatiotemporal organization of signaling complexes within the context of plasma membrane nanodomains has remained a highly challenging task…”
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STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling by Arimoto, Kei-ichiro, Löchte, Sara, Stoner, Samuel A, Burkart, Christoph, Zhang, Yue, Miyauchi, Sayuri, Wilmes, Stephan, Fan, Jun-Bao, Heinisch, Jürgen J, Li, Zhi, Yan, Ming, Pellegrini, Sandra, Colland, Frédéric, Piehler, Jacob, Zhang, Dong-Er

“…STAT2, previously known as a positive effector of interferon signaling, is now shown to participate in negative feedback and suppression of this signaling…”
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Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane by Löchte, Sara, Waichman, Sharon, Beutel, Oliver, You, Changjiang, Piehler, Jacob

“…Interactions of proteins in the plasma membrane are notoriously challenging to study under physiological conditions. We report in this paper a generic approach…”
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Spatiotemporally Controlled Reorganization of Signaling Complexes in the Plasma Membrane of Living Cells by Wedeking, Tim, Löchte, Sara, Birkholz, Oliver, Wallenstein, Alexander, Trahe, Julia, Klingauf, Jürgen, Piehler, Jacob, You, Changjiang

“…Triggered immobilization of proteins in the plasma membrane of living cells into functional micropatterns is established by using an adaptor protein, which is…”
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Self-Controlled Monofunctionalization of Quantum Dots for Multiplexed Protein Tracking in Live Cells by You, Changjiang, Wilmes, Stephan, Beutel, Oliver, Löchte, Sara, Podoplelowa, Yulia, Roder, Friedrich, Richter, Christian, Seine, Thomas, Schaible, Dirk, Uzé, Gilles, Clarke, Samuel, Pinaud, Fabien, Dahan, Maxime, Piehler, Jacob

“…Functionalization of quantum dots (QDs) was achieved by controlling the surface density of functional groups by electrostatic repulsion. These QDs were…”
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Gain of Function Mutations in Membrane Region M2C2 of KtrB Open a Gate Controlling K+ Transport by the KtrAB System from Vibrio alginolyticus by Hänelt, Inga, Löchte, Sara, Sundermann, Lea, Elbers, Katharina, Vor der Brüggen, Marc, Bakker, Evert P.

“…KtrB, the K+-translocating subunit of the Na+-dependent bacterial K+ uptake system KtrAB, consists of four M1PM2 domains, in which M1 and M2 are transmembrane…”
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Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers by Dirscherl, Cindy, Löchte, Sara, Hein, Zeynep, Kopicki, Janine-Denise, Harders, Antonia Regina, Linden, Noemi, Karner, Andreas, Preiner, Johannes, Weghuber, Julian, Garcia-Alai, Maria, Uetrecht, Charlotte, Zacharias, Martin, Piehler, Jacob, Lanzerstorfer, Peter, Springer, Sebastian

“…At the plasma membrane of mammalian cells, major histocompatibility complex class I molecules (MHC-I) present antigenic peptides to cytotoxic T cells…”
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Dissociation of β2m from cell surface MHC class I triggers formation of noncovalent, transient heavy chain dimers by Springer, Sebastian, Dirscherl, Cindy, Löchte, Sara, Hein, Zeynep, Kopicki, Janine-Denise, Harders, Antonia, Linden, Noemi, Weghuber, Julian, Garcia-Alai, Maria, Uetrecht, Charlotte, Zacharias, Martin, Lanzerstorfer, Peter, Piehler, Jacob

“…Abstract Major histocompatibility complex class I molecules (MHC I) that lose the antigenic peptide and the light chain beta-2 microglobulin (β2m) to become…”
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New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2V617F Mutation by Wilmes, Stephan, Hafer, Maximillian, Stanly, Tess A, Moraga, Ignacio, Vuorio, Joni, Poojari, Chetan, Sharma, Vivek, Löchte, Sara, Pulgar Prieto, Katiuska, Tucker, Julie A, Hubbard, Stevan R, Garcia, K.Christopher, Vattulainen, Ilpo, Hitchcock, Ian, Piehler, Jacob

“…Janus kinase (JAK2)V617F is the most common mutation found in patients with Philadelphia chromosome negative myeloproliferative neoplasms (Ph- MPNs). The…”
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Self‐Controlled Monofunctionalization of Quantum Dots for Multiplexed Protein Tracking in Live Cells by You, Changjiang, Wilmes, Stephan, Beutel, Oliver, Löchte, Sara, Podoplelowa, Yulia, Roder, Friedrich, Richter, Christian, Seine, Thomas, Schaible, Dirk, Uzé, Gilles, Clarke, Samuel, Pinaud, Fabien, Dahan, Maxime, Piehler, Jacob

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IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs by Shemesh, Maya, Lochte, Sara, Piehler, Jacob, Schreiber, Gideon

“…Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the…”
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PS1-029. Dynamics of the Type I interferon receptor assembly in the plasma membrane by Wilmes, Stephan, Löchte, Sara, Janning, Dennis, Kroll, Cindy, Beutel, Oliver, You, Changjiang, Richter, Christian Paolo, Pellegrini, Sandra, Piehler, Jacob

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Self-Controlled Monofunctionalization of Quantum Dots for Multiplexed Protein Tracking in Live Cells by You, Changjiang, Wilmes, Stephan, Beutel, Oliver, Löchte, Sara, Podoplelowa, Yulia, Roder, Friedrich, Richter, Christian, Seine, Thomas, Schaible, Dirk, Uzé, Gilles, Clarke, Samuel, Pinaud, Fabien, Dahan, Maxime, Piehler, Jacob

“…Die Funktionalisierung von Quantenpunkten (QDs) gelang, wenn die Oberflächendichte an funktionellen Gruppen durch elektrostatische Abstoßung eingestellt wurde…”
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