Search Results - "López Sambrooks, Cecilia"

Arginylated Calreticulin at Plasma Membrane Increases Susceptibility of Cells to Apoptosis by López Sambrooks, Cecilia, Carpio, Marcos A., Hallak, Marta E.

“…Post-translational modifications of proteins are important for the regulation of cell fate and functions; one of these post-translational modifications is…”
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Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors by Lopez Sambrooks, Cecilia, Baro, Marta, Quijano, Amanda, Narayan, Azeet, Cui, Wei, Greninger, Patricia, Egan, Regina, Patel, Abhijit, Benes, Cyril H, Saltzman, W Mark, Contessa, Joseph N

“…Asparagine (N)-linked glycosylation is a posttranslational modification essential for the function of complex transmembrane proteins. However, targeting…”
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The arginylation-dependent association of calreticulin with stress granules is regulated by calcium by Carpio, Marcos A, López Sambrooks, Cecilia, Durand, Edith S, Hallak, Marta E

“…Post-translational modifications of proteins are important for the regulation of cell functions; one of these modifications is post-translational arginylation…”
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Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity by Baro, Marta, Lopez Sambrooks, Cecilia, Quijano, Amanda, Saltzman, W Mark, Contessa, Joseph

“…Parallel signaling reduces the effects of receptor tyrosine kinase (RTK)-targeted therapies in glioma. We hypothesized that inhibition of protein N-linked…”
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Neuregulin Signaling Is a Mechanism of Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma by Baro, Marta, Lopez Sambrooks, Cecilia, Burtness, Barbara A, Lemmon, Mark A, Contessa, Joseph N

“…EGFR signaling confers resistance to radiotherapy and is a validated target in head and neck squamous cell carcinoma (HNSCC). The inhibition of EGFR in…”
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Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells by Lopez-Sambrooks, Cecilia, Shrimal, Shiteshu, Khodier, Carol, Flaherty, Daniel P, Rinis, Natalie, Charest, Jonathan C, Gao, Ningguo, Zhao, Peng, Wells, Lance, Lewis, Timothy A, Lehrman, Mark A, Gilmore, Reid, Golden, Jennifer E, Contessa, Joseph N

“…A high-throughput screen identifies NGI-1 as an inhibitor of oligosaccharyltransferase, preventing transfer of N-linked glycans to proteins. NGI-1 blocked EGFR…”
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Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity by Cazet, Aurélie, Charest, Jonathan, Bennett, Daniel C, Sambrooks, Cecilia Lopez, Contessa, Joseph N

“…Asparagine-linked glycosylation is an endoplasmic reticulum co- and post-translational modification that enables the transit and function of receptor tyrosine…”
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Calreticulin-dimerization induced by post-translational arginylation is critical for stress granules scaffolding by Carpio, Marcos A., Decca, María B., Lopez Sambrooks, Cecilia, Durand, Edith S., Montich, Guillermo G., Hallak, Marta E.

“…Protein arginylation mediated by arginyl-tRNA protein transferase is a post-translational modification that occurs widely in biology, it has been shown to…”
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Abstract 4998: Novel N-glycosilation inhibitor blocks proliferation of EGFR-dependent NSCLC by Lopez Sambrooks, Cecilia, Contessa, Joseph N.

“…Purpose: Receptor Tyrosine Kinase (RTK) are transmembrane glycoproteins that are known to drive cellular proliferation in non-small cell lung cancer (NSCLC)…”
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