Search Results - "López N, Mercedes"

Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape by Salazar-Onfray, Flavio, Lopez, Mercedes N, Mendoza-Naranjo, Ariadna

“…Abstract The role of cytokines in modulating the formation of new tumors is mediated by their ability to regulate antigen-specific anti-tumor responses and by…”
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Role of Dendritic Cells in the Induction of Lymphocyte Tolerance by Osorio, Fabiola, Fuentes, Camila, López, Mercedes N, Salazar-Onfray, Flavio, González, Fermín E

“…The ability of dendritic cells (DCs) to trigger tolerance or immunity is dictated by the context in which an antigen is encountered. A large body of evidence…”
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Prolonged Survival of Dendritic Cell–Vaccinated Melanoma Patients Correlates With Tumor-Specific Delayed Type IV Hypersensitivity Response and Reduction of Tumor Growth Factor β-Expressing T Cells by Mercedes N. López, Cristian Pereda, Gabriela Segal, Leonel Muñoz, Raquel Aguilera, Fermín E. González, Alejandro Escobar, Alexandra Ginesta, Diego Reyes, Rodrigo González, Ariadna Mendoza-Naranjo, Milton Larrondo, Alvaro Compán, Carlos Ferrada, Flavio Salazar-Onfray

“…The aim of this work was to assess immunologic response, disease progression, and post-treatment survival of melanoma patients vaccinated with autologous…”
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Tumor cell lysates as immunogenic sources for cancer vaccine design by González, Fermín E, Gleisner, Alejandra, Falcón-Beas, Felipe, Osorio, Fabiola, López, Mercedes N, Salazar-Onfray, Flavio

“…Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the…”
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Haptoglobin Induces a Specific Proteomic Profile and a Mature-Associated Phenotype on Primary Human Monocyte-Derived Dendritic Cells by Torres, Alfredo, Vivanco, Sheilah, Lavín, Francisca, Pereda, Cristián, Chernobrovkin, Alexey, Gleisner, Alejandra, Alcota, Marcela, Larrondo, Milton, López, Mercedes N., Salazar-Onfray, Flavio, Zubarev, Roman A., González, Fermín E.

“…Damage-associated molecular patterns (DAMPs) play a critical role in dendritic cells (DCs) ability to trigger a specific and efficient adaptive immune response…”
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Heat-shock induction of tumor-derived danger signals mediates rapid monocyte differentiation into clinically effective dendritic cells by Aguilera, Raquel, Saffie, Carlos, Tittarelli, Andrés, González, Fermín E, Ramírez, Marcos, Reyes, Diego, Pereda, Cristián, Hevia, Daniel, García, Tamara, Salazar, Lorena, Ferreira, Arturo, Hermoso, Marcela, Mendoza-Naranjo, Ariadna, Ferrada, Carlos, Garrido, Paola, López, Mercedes N, Salazar-Onfray, Flavio

“…This study characterizes, biologically and clinically, a novel type of dendritic cells (DC) produced in the short term and called tumor antigen-presenting…”
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Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory functions by Falcón-Beas, Cristián, Tittarelli, Andrés, Mora-Bau, Gabriela, Tempio, Fabián, Pérez, Claudio, Hevia, Daniel, Behrens, Carolina, Flores, Iván, Falcón-Beas, Felipe, Garrido, Paola, Ascui, Gabriel, Pereda, Cristián, González, Fermín E., Salazar-Onfray, Flavio, López, Mercedes N.

“…Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on…”
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Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside by Palacios, Miriam, Tampe, Ricardo, Del Campo, Miguel, Zhong, Ta-Ying, López, Mercedes N., Salazar-Onfray, Flavio, Becker, María Inés

“…Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated…”
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Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro by Falcón-Beas, Cristian, Falcón-Beas, Felipe, Galindo, Mario, Salazar-Onfray, Flavio, González, Fermín E., López, Mercedes N., Fuentes, Camila, Tempio, Fabián, Pereda, Cristián, Rojas-Sepúlveda, Daniel, Soto, Dafne, Tittarelli, Andrés, Hevia, Daniel, Flores, Iván, Gatica, Jimena

“…Ovarian epithelial carcinoma (OEC) is the most frequent ovarian tumor, characterized by a high mortality in advanced stages where conventional therapies are…”
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Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity by Tittarelli, Andrés, Mendoza-Naranjo, Ariadna, Farías, Marcela, Guerrero, Israel, Ihara, Fumitaka, Wennerberg, Erik, Riquelme, Sebastian, Gleisner, Alejandra, Kalergis, Alexis, Lundqvist, Andreas, López, Mercedes N, Chambers, Benedict J, Salazar-Onfray, Flavio

“…Gap junctions (GJs) mediate intercellular communication between adjacent cells. Previously, we showed that connexin 43 (Cx43), the main GJ protein in the…”
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Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy by Zubarev, Roman A., López, Mercedes N., Tittarelli, Andrés, García-Salum, Tamara, Pereda, Cristián, Chernobrovkin, Alexey, González, Fermín E., Salazar-Onfray, Flavio

“…Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in cancer immunotherapy. During the last decade, we…”
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Long-Term Survival and Immune Response Dynamics in Melanoma Patients Undergoing TAPCells-Based Vaccination Therapy by Tittarelli, Andrés, Pereda, Cristian, Gleisner, María A, López, Mercedes N, Flores, Iván, Tempio, Fabián, Lladser, Alvaro, Achour, Adnane, González, Fermín E, Durán-Aniotz, Claudia, Miranda, Juan P, Larrondo, Milton, Salazar-Onfray, Flavio

“…Cancer vaccines present a promising avenue for treating immune checkpoint blockers (ICBs)-refractory patients, fostering immune responses to modulate the tumor…”
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Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients by Tittarelli, Andrés, González, Fermín E., Pereda, Cristián, Mora, Gabriela, Muñoz, Leonel, Saffie, Carlos, García, Tamara, Díaz, David, Falcón, Cristián, Hermoso, Marcela, López, Mercedes N., Salazar-Onfray, Flavio

“…Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation…”
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The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses by Durán-Aniotz, Claudia, Segal, Gabriela, Salazar, Lorena, Pereda, Cristián, Falcón, Cristián, Tempio, Fabián, Aguilera, Raquel, González, Rodrigo, Pérez, Claudio, Tittarelli, Andrés, Catalán, Diego, Nervi, Bruno, Larrondo, Milton, Salazar-Onfray, Flavio, López, Mercedes N.

“…Introduction Immunization with autologous dendritic cells (DCs) loaded with a heat shock-conditioned allogeneic melanoma cell lysate caused lysate-specific…”
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TAPCells, the Chilean dendritic cell vaccine against melanoma and prostate cancer by Salazar-Onfray, Flavio, Pereda, Cristián, Reyes, Diego, López, Mercedes N

“…Here we summarize 10 years of effort in the development of a biomedical innovation with global projections. This innovation consists of a novel method for the…”
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Interleukin 10 decreases MICA expression on melanoma cell surface by Serrano, Antonio E, Menares‐Castillo, Evelyn, Garrido‐Tapia, Macarena, Ribeiro, Carolina Hager, Hernández, Carolina J, Mendoza‐Naranjo, Ariadna, Gatica‐Andrades, Marcela, Valenzuela‐Diaz, Rodrigo, Zúñiga, Roberto, López, Mercedes N, Salazar‐Onfray, Flavio, Aguillón, Juan‐Carlos, Molina, María‐Carmen

“…Natural‐killer group 2, member D (NKG2D) binds to a variety of ligands, including the major histocompatibility complex (MHC) class I chain‐related proteins…”
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Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells by Torres, Angelo, Vargas, Yosselyn, Uribe, Daniel, Jaramillo, Catherine, Gleisner, Alejandra, Salazar-Onfray, Flavio, López, Mercedes N, Melo, Rómulo, Oyarzún, Carlos, San Martín, Rody, Quezada, Claudia

“…MRP1 transporter correlates positively with glioma malignancy and the Multiple Drug Resistance (MDR) phenotype in Glioblastoma Multiforme (GBM). Evidence shows…”
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Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation by Mendoza-Naranjo, Ariadna, Bouma, Gerben, Pereda, Cristián, Ramírez, Marcos, Webb, Kevin F, Tittarelli, Andrés, López, Mercedes N, Kalergis, Alexis M, Thrasher, Adrian J, Becker, David L, Salazar-Onfray, Flavio

“…Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that…”
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Functional Gap Junctions Facilitate Melanoma Antigen Transfer and Cross-Presentation between Human Dendritic Cells by Mendoza-Naranjo, Ariadna, Saez, Pablo J, Johansson, C. Christian, Ramirez, Marcos, Mandakovic, Dinka, Pereda, Cristian, Lopez, Mercedes N, Kiessling, Rolf, Saez, Juan C, Salazar-Onfray, Flavio

“…Previously, we found that human dendritic cells (hDCs) pulsed with a melanoma cell lysate (MCL) and stimulated with TNF-alpha (MCL/TNF) acquire a mature…”
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Pure platelet-rich plasma and supernatant of calcium-activated P-PRP induce different phenotypes of human macrophages by Escobar, Gisselle, Escobar, Alejandro, Ascui, Gabriel, Tempio, Fabián I, Ortiz, María C, Pérez, Claudio A, López, Mercedes N

“…This study aimed to evaluate the effect of two platelet preparations used in the clinic, pure platelet-rich plasma (P-PRP) and the supernatant of…”
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