Search Results - "López Lluch, Guillermo"

Calorie restriction as an intervention in ageing by López‐Lluch, Guillermo, Navas, Plácido

“…Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory process and affects life‐ and healthspan. Calorie restriction…”
Get full text

Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD) by Carneros, David, López-Lluch, Guillermo, Bustos, Matilde

“…Non-alcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years. Diet and exercise interventions are the…”
Get full text

Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway by Beà, Aida, Valero, Juan García, Irazoki, Andrea, Lana, Carlos, López‐Lluch, Guillermo, Portero‐Otín, Manuel, Pérez‐Galán, Patricia, Inserte, Javier, Ruiz‐Meana, Marisol, Zorzano, Antonio, Llovera, Marta, Sanchis, Daniel

“…Cardiovascular diseases are the leading cause of death globally and more than four out of five cases are due to ischemic events. Cardiac fibroblasts (CF)…”
Get full text

Cellular Models for Primary CoQ Deficiency Pathogenesis Study by Santos-Ocaña, Carlos, Cascajo, María V., Alcázar-Fabra, María, Staiano, Carmine, López-Lluch, Guillermo, Brea-Calvo, Gloria, Navas, Plácido

“…Primary coenzyme Q10 (CoQ) deficiency includes a heterogeneous group of mitochondrial diseases characterized by low mitochondrial levels of CoQ due to…”
Get full text

The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle by Gutiérrez-Casado, Elena, Khraiwesh, Husam, López-Domínguez, José A, Montero-Guisado, Jesús, López-Lluch, Guillermo, Navas, Plácido, de Cabo, Rafael, Ramsey, Jon J, González-Reyes, José A, Villalba, José M

“…Loss of skeletal muscle mass and function is a hallmark of aging. This phenomenon has been related to a dysregulation of mitochondrial function and…”
Get full text

Anti-inflammatory effect of resveratrol in old mice liver by Tung, Bui Thanh, Rodríguez-Bies, Elisabeth, Talero, Elena, Gamero-Estévez, Enrique, Motilva, Virginia, Navas, Plácido, López-Lluch, Guillermo

“…Inflammation is a hallmark of aging. Caloric restriction and resveratrol (RSV) have shown important effects on prevention of oxidative stress and inflammation…”
Get full text

Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity by López-Lluch, Guillermo

“…Mitochondrial homeostasis is basic to maintain a balanced metabolic activity in fat accumulating tissues including adipose tissue, muscle and liver. Ageing and…”
Get full text

Toward Consensus Epitopes B and T of Tropomyosin Involved in Cross-Reactivity across Diverse Allergens: An In Silico Study by Martínez, Dalgys, Fang, Luis, Meza-Torres, Catherine, Garavito, Gloria, López-Lluch, Guillermo, Egea, Eduardo

“…Tropomyosin (TM) is a pan-allergen with cross-reactivity to arthropods, insects, and nematodes in tropical regions. While IgE epitopes of TM contribute to…”
Get full text

An AlphaFold Structure Analysis of COQ2 as Key a Component of the Coenzyme Q Synthesis Complex by Vargas-Pérez, María de Los Ángeles, Devos, Damien Paul, López-Lluch, Guillermo

“…Coenzyme Q (CoQ) is a lipidic compound that is widely distributed in nature, with crucial functions in metabolism, protection against oxidative damage and…”
Get full text

The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice by López-Domínguez, José A, Ramsey, Jon J, Tran, Dianna, Imai, Denise M, Koehne, Amanda, Laing, Steven T, Griffey, Stephen M, Kim, Kyoungmi, Taylor, Sandra L, Hagopian, Kevork, Villalba, José M, López-Lluch, Guillermo, Navas, Plácido, McDonald, Roger B

“…Calorie restriction (CR) without malnutrition extends life span in several animal models. It has been proposed that a decrease in the amount of polyunsaturated…”
Get full text

The Evolution of Physical Performance throughout an Entire Season in Female Football Players by Reyes-Laredo, Francisco, Pareja-Blanco, Fernando, López-Lluch, Guillermo, Rodríguez-Bies, Elisabet

“…Research on the evolution of performance throughout a season in team sports is scarce and mainly focused on men's teams. Our aim in this study was to examine…”
Get full text

Coenzyme Q homeostasis in aging: Response to non-genetic interventions by López-Lluch, Guillermo

“…Coenzyme Q (CoQ) is a key component for many essential metabolic and antioxidant activities in cells in mitochondria and cell membranes. Mitochondrial…”
Get full text

Coenzyme Q at the Hinge of Health and Metabolic Diseases by Hernández-Camacho, Juan Diego, García-Corzo, Laura, Fernández-Ayala, Daniel José Moreno, Navas, Plácido, López-Lluch, Guillermo

“…Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all…”
Get full text

Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study by De Egea, Gloria Garavito, Domínguez-Vargas, Alex, Fang, Luis, Pereira-Sanandrés, Nicole, Rodríguez, Jonathan, Aroca-Ma, Espítatela, Zilac

“…Background Adiponectin and leptin are pivotal in the regulation of metabolism. Pediatric lupus nephritis (pLN), a manifestation of childhood systemic lupus…”
Get full text

Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor by Fontan-Lozano, Angela, Saez-Cassanelli, Jose Luis, Inda, Mari Carmen, de los Santos-Arteaga, Mercedes, Sierra-Dominguez, Sergio Antonio, Lopez-Lluch, Guillermo, Delgado-Garcia, Jose Maria, Carrion, Angel Manuel

“…One of the main focal points of aging research is the search for treatments that will prevent or ameliorate the learning and memory deficiencies associated…”
Get full text

Calorie Restriction Rescues Mitochondrial Dysfunction in Adck2-Deficient Skeletal Muscle by Hernández-Camacho, Juan Diego, Fernández-Ayala, Daniel J. M., Vicente-García, Cristina, Navas-Enamorado, Ignacio, López-Lluch, Guillermo, Oliva, Clara, Artuch, Rafael, Garcia-Villoria, Judith, Ribes, Antonia, de Cabo, Rafael, Carvajal, Jaime J., Navas, Plácido

“…ADCK2 haploinsufficiency-mediated mitochondrial coenzyme Q deficiency in skeletal muscle causes mitochondrial myopathy associated with defects in…”
Get full text

Inorganic Pyrophosphatase Defects Lead to Cell Cycle Arrest and Autophagic Cell Death through NAD+ Depletion in Fermenting Yeast by Serrano-Bueno, Gloria, Hernández, Agustín, López-Lluch, Guillermo, Pérez-Castiñeira, José Román, Navas, Plácido, Serrano, Aurelio

“…Inorganic pyrophosphatases are required for anabolism to take place in all living organisms. Defects in genes encoding these hydrolytic enzymes are considered…”
Get full text

Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species by Blasco, Natividad, Beà, Aida, Barés, Gisel, Girón, Cristina, Navaridas, Raúl, Irazoki, Andrea, López-Lluch, Guillermo, Zorzano, Antonio, Dolcet, Xavier, Llovera, Marta, Sanchis, Daniel

“…The apoptotic nuclease EndoG is involved in mitochondrial DNA replication. Previous results suggested that, in addition to regulate cardiomyocyte hypertrophy,…”
Get full text

Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2 by Siendones, Emilio, SantaCruz-Calvo, Sara, Martín-Montalvo, Alejandro, Cascajo, María V, Ariza, Julia, López-Lluch, Guillermo, Villalba, José M, Acquaviva-Bourdain, Cécile, Roze, Emmanuel, Bernier, Michel, de Cabo, Rafael, Navas, Plácido

“…Membrane-bound CYB5R3 deficiency in humans causes recessive hereditary methaemoglobinaemia (RHM), an incurable disease that is characterized by severe…”
Get more information

Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie‐restricted mice by Calvo‐Rubio, Miguel, Burón, Mª Isabel, López‐Lluch, Guillermo, Navas, Plácido, Cabo, Rafael, Ramsey, Jon J., Villalba, José M., González‐Reyes, José A.

“…Summary Calorie restriction (CR) has been repeatedly shown to prevent cancer, diabetes, hypertension, and other age‐related diseases in a wide range of…”
Get full text