Search Results - "López‐Rodas, Gerardo"

Pentoxifylline and Oxypurinol: Potential Drugs to Prevent the "Cytokine Release (Storm) Syndrome" Caused by SARS-CoV-2? by López-Iranzo, Francisco J, López-Rodas, Ana M, Franco, Luis, López-Rodas, Gerardo

“…COVID-19, caused by SARS-CoV-2, is a potentially lethal, rapidly-expanding pandemic and many efforts are being carried out worldwide to understand and control…”
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Vitamin A Status Modulates Epithelial Mesenchymal Transition in the Lung: The Role of Furin by Cabezuelo, M Teresa, Torres, Luis, Ortiz-Zapater, Elena, López-Rodas, Gerardo, Marín, M Pilar, Timoneda, Joaquín, Viña, Juan R, Zaragozá, Rosa, Barber, Teresa

“…Vitamin A deficiency (VAD) induced TGF-β hyperactivation and reduced expression of cell adhesion proteins in the lung, suggesting that the disruption of…”
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Perturbed glucose metabolism: insights into multiple sclerosis pathogenesis by Mathur, Deepali, López-Rodas, Gerardo, Casanova, Bonaventura, Marti, Maria Burgal

“…Multiple sclerosis (MS) is a complex debilitating disease of the central nervous system (CNS) perceived to result from the autoimmune effect of T cells in…”
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Cross-talk between oxidative stress and pro-inflammatory cytokines in acute pancreatitis: a key role for protein phosphatases by Escobar, Javier, Pereda, Javier, Arduini, Alessandro, Sandoval, Juan, Sabater, Luis, Aparisi, Luis, López-Rodas, Gerardo, Sastre, Juan

“…Acute pancreatitis is an acute inflammatory process localized in the pancreatic gland that frequently involves peripancreatic tissues. It is still under…”
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Interaction between cytokines and oxidative stress in acute pancreatitis by Pereda, Javier, Sabater, Luis, Aparisi, Luis, Escobar, Javier, Sandoval, Juan, Viña, José, López-Rodas, Gerardo, Sastre, Juan

“…Acute pancreatitis is an inflammation initially localized in the pancreatic gland which may lead to local and systemic complications. The development of severe…”
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Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase by Rius-Pérez, Sergio, Pérez, Salvador, Torres-Cuevas, Isabel, Martí-Andrés, Pablo, Taléns-Visconti, Raquel, Paradela, Alberto, Guerrero, Laura, Franco, Luis, López-Rodas, Gerardo, Torres, Luis, Corrales, Fernando, Sastre, Juan

“…Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work…”
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Role for Chromatin Remodeling Factor Chd1 in Learning and Memory by Schoberleitner, Ines, Mutti, Anna, Sah, Anupam, Wille, Alexandra, Gimeno-Valiente, Francisco, Piatti, Paolo, Kharitonova, Maria, Torres, Luis, López-Rodas, Gerardo, Liu, Jeffrey J, Singewald, Nicolas, Schwarzer, Christoph, Lusser, Alexandra

“…Precise temporal and spatial regulation of gene expression in the brain is a prerequisite for cognitive processes such as learning and memory. Epigenetic…”
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Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels by Sacilotto, Natalia, Castillo, Josefa, Riffo-Campos, Ángela L, Flores, Juana M, Hibbitt, Olivia, Wade-Martins, Richard, López, Carlos, Rodrigo, M Isabel, Franco, Luis, López-Rodas, Gerardo

“…The prognosis of hepatocellular carcinoma patients is usually poor, the size of tumors being a limiting factor for surgical treatments. Present results suggest…”
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Epigenetic transcriptional regulation of the growth arrest-specific gene 1 (Gas1) in hepatic cell proliferation at mononucleosomal resolution by Sacilotto, Natalia, Espert, Antonio, Castillo, Josefa, Franco, Luis, López-Rodas, Gerardo

“…Gas1 (growth arrest-specific 1) gene is known to inhibit cell proliferation in a variety of models, but its possible implication in regulating quiescence in…”
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EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells by Roda, Desamparados, Castillo, Josefa, Telechea-Fernández, Marcelino, Gil, Anabel, López-Rodas, Gerardo, Franco, Luís, González-Rodríguez, Patricia, Roselló, Susana, Pérez-Fidalgo, J Alejandro, García-Trevijano, Elena R, Cervantes, Andrés, Zaragozá, Rosa

“…KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However,…”
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Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol by Escobar, Javier, Pereda, Javier, Arduini, Alessandro, Sandoval, Juan, Moreno, Mari Luz, Pérez, Salvador, Sabater, Luis, Aparisi, Luis, Cassinello, Norberto, Hidalgo, Juan, Joosten, Leo A.B., Vento, Máximo, López-Rodas, Gerardo, Sastre, Juan

“…Co-treatment with oxypurinol (O) and pentoxifylline (P) prevents oxidative and nitrosative stress in pancreas in acute pancreatitis (AP). The effect of…”
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Epigenetic modifiers are necessary but not sufficient for reprogramming non-myelinating cells into myelin gene-expressing cells by Liu, Jia, Sandoval, Juan, Doh, Sung Tae, Cai, Li, López-Rodas, Gerardo, Casaccia, Patrizia

“…Modifications on specific histone residues and DNA methylation play an essential role in lineage choice and cellular reprogramming. We have previously shown…”
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RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription by Sandoval, Juan, Rodríguez, José L., Tur, Gema, Serviddio, Gaetano, Pereda, Javier, Boukaba, Abdelhalim, Sastre, Juan, Torres, Luis, Franco, Luis, López-Rodas, Gerardo

“…We describe a procedure, RNAPol-ChIP, to measure actual transcriptional rate. It consists of the detection, by chromatin immunoprecipitation (ChIP), of RNA…”
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Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions by Pedre, Xiomara, Mastronardi, Fabrizio, Bruck, Wolfgang, López-Rodas, Gerardo, Kuhlmann, Tanja, Casaccia, Patrizia

“…The epigenetic identity of oligodendrocytes is modulated by posttranslational modifications of histones. Acetylation of histone H3 results from the balance…”
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Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity by Bordoni, Laura, Nasuti, Cinzia, Fedeli, Donatella, Galeazzi, Roberta, Laudadio, Emiliano, Massaccesi, Luca, López-Rodas, Gerardo, Gabbianelli, Rosita

“…Permethrin is a synthetic pyrethroid extensively used as anti-woodworm agent and for indoor and outdoor pest control. The main route of human exposure is…”
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Alternative Splicing, Epigenetic Modifications and Cancer: A Dangerous Triangle, or a Hopeful One? by Gimeno-Valiente, Francisco, López-Rodas, Gerardo, Castillo, Josefa, Franco, Luis

“…The alteration of epigenetic modifications often causes cancer onset and development. In a similar way, aberrant alternative splicing may result in oncogenic…”
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The Many Roads from Alternative Splicing to Cancer: Molecular Mechanisms Involving Driver Genes by Gimeno-Valiente, Francisco, López-Rodas, Gerardo, Castillo, Josefa, Franco, Luis

“…Cancer driver genes are either oncogenes or tumour suppressor genes that are classically activated or inactivated, respectively, by driver mutations…”
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Disturbed Glucose Metabolism in Rat Neurons Exposed to Cerebrospinal Fluid Obtained from Multiple Sclerosis Subjects by Mathur, Deepali, María-Lafuente, Eva, Ureña-Peralta, Juan R, Sorribes, Lucas, Hernández, Alberto, Casanova, Bonaventura, López-Rodas, Gerardo, Coret-Ferrer, Francisco, Burgal-Marti, Maria

“…Axonal damage is widely accepted as a major cause of permanent functional disability in Multiple Sclerosis (MS). In relapsing-remitting MS, there is a…”
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Reciprocal regulation of the human sterol regulatory element binding protein (SREBP)-1a promoter by Sp1 and EGR-1 transcription factors by Fernández-Álvarez, Ana, Tur, Gemma, López-Rodas, Gerardo, Casado, Marta

“…Sterol regulatory element binding protein (SREBP)-1a is a transcription factor that is highly expressed in actively growing cells, and is involved in the…”
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Redox signaling and histone acetylation in acute pancreatitis by Escobar, Javier, Pereda, Javier, López-Rodas, Gerardo, Sastre, Juan

“…Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines in the activation phase of inflammation, particularly through…”
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