Search Results - "López‐Ríos, Fernando"

Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non-Small-Cell Lung Cancer by Büttner, Reinhard, Gosney, John R, Skov, Birgit Guldhammer, Adam, Julien, Motoi, Noriko, Bloom, Kenneth J, Dietel, Manfred, Longshore, John W, López-Ríos, Fernando, Penault-Llorca, Frédérique, Viale, Giuseppe, Wotherspoon, Andrew C, Kerr, Keith M, Tsao, Ming-Sound

“…Purpose Three programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for treatment of non-small-cell lung cancer (NSCLC)…”
Get full text

A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development by Jimeno, Antonio, Feldmann, Georg, Suárez-Gauthier, Ana, Rasheed, Zeshaan, Solomon, Anna, Zou, Gang-Ming, Rubio-Viqueira, Belen, García-García, Elena, López-Ríos, Fernando, Matsui, William, Maitra, Anirban, Hidalgo, Manuel

“…There is an enormous gap between the antiproliferative and in vivo antitumor efficacy of gemcitabine in cell line-based models and its clinical efficacy. This…”
Get full text

Accurate identification of ALK positive lung carcinoma patients: novel FDA-cleared automated fluorescence in situ hybridization scanning system and ultrasensitive immunohistochemistry by Conde, Esther, Suárez-Gauthier, Ana, Benito, Amparo, Garrido, Pilar, García-Campelo, Rosario, Biscuola, Michele, Paz-Ares, Luis, Hardisson, David, de Castro, Javier, Camacho, M Carmen, Rodriguez-Abreu, Delvys, Abdulkader, Ihab, Ramirez, Josep, Reguart, Noemí, Salido, Marta, Pijuán, Lara, Arriola, Edurne, Sanz, Julián, Folgueras, Victoria, Villanueva, Noemí, Gómez-Román, Javier, Hidalgo, Manuel, López-Ríos, Fernando

“…Based on the excellent results of the clinical trials with ALK-inhibitors, the importance of accurately identifying ALK positive lung cancer has never been…”
Get full text

A comparison of EGFR mutation testing methods in lung carcinoma: direct sequencing, real-time PCR and immunohistochemistry by Angulo, Bárbara, Conde, Esther, Suárez-Gauthier, Ana, Plaza, Carlos, Martínez, Rebeca, Redondo, Pilar, Izquierdo, Elisa, Rubio-Viqueira, Belén, Paz-Ares, Luis, Hidalgo, Manuel, López-Ríos, Fernando

“…The objective of this study is to compare two EGFR testing methodologies (a commercial real-time PCR kit and a specific EGFR mutant immunohistochemistry), with…”
Get full text

The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group by Thunnissen, Erik, Kerr, Keith M, Herth, Felix J.F, Lantuejoul, Sylvie, Papotti, Mauro, Rintoul, Robert C, Rossi, Giulio, Skov, Birgit G, Weynand, Birgit, Bubendorf, Lukas, Katrien, Grünberg, Johansson, Leif, López-Ríos, Fernando, Ninane, Vincent, Olszewski, Włodzimierz, Popper, Helmut, Jaume, Sauleda, Schnabel, Philipp, Thiberville, Luc, Laenger, Florian

“…Highlights ► The diagnosis of lung cancer involves the identification and complete classification of malignancy. ► New therapeutic options require specific…”
Get full text

Concordance in the estimation of tumor percentage in non-small cell lung cancer using digital pathology by Carretero-Barrio, Irene, Pijuan, Lara, Illarramendi, Adrián, Curto, Daniel, López-Ríos, Fernando, Estébanez-Gallo, Ángel, Castellvi, Josep, Granados-Aparici, Sofía, Compañ-Quilis, Desamparados, Noguera, Rosa, Esteban-Rodríguez, Isabel, Sánchez-Güerri, Ignacio, Ramos-Guerra, Ana Delia, Ortuño, Juan Enrique, Garrido, Pilar, Ledesma-Carbayo, María Jesús, Benito, Amparo, Palacios, José

“…The incorporation of digital pathology in clinical practice will require the training of pathologists in digital skills. Our study aimed to assess the…”
Get full text

Global gene expression profiling of pleural mesotheliomas : Overexpression of aurora kinases and P16/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction by LOPEZ-RIOS, Fernando, CHUAI, Shannon, RUSCH, Valerie, OLSHEN, Adam B, LADANYI, Marc, FLORES, Raja, SHIMIZU, Shigeki, OHNO, Takatoshi, WAKAHARA, Kazuhiko, ILLEI, Peter B, HUSSAIN, Sanaa, KRUG, Lee, ZAKOWSKI, Maureen F

“…Most gene expression profiling studies of mesothelioma have been based on relatively small sample numbers, limiting their statistical power. We did Affymetrix…”
Get full text

Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas by LOPEZ-RIOS, Fernando, SANCHEZ-ARAGO, Maria, GARCIA-GARCIA, Elena, ORTEGA, Alvaro D, BERRENDERO, José R, POZO-RODRIGUEZ, Francisco, LOPEZ-ENCUENTRA, Angel, BALLESTIN, Claudio, CUEZVA, José M

“…The down-regulation of the catalytic subunit of the mitochondrial H+-ATP synthase (beta-F1-ATPase) is a hallmark of most human carcinomas. This characteristic…”
Get full text

External Quality Assessment for KRAS Testing Is Needed: Setup of a European Program and Report of the First Joined Regional Quality Assessment Rounds by Bellon, Ellen, Ligtenberg, Marjolijn J.L., Tejpar, Sabine, Cox, Karen, Hertogh, Gert, Stricker, Karin, Edsjö, Anders, Gorgoulis, Vassilis, Höfler, Gerald, Jung, Andreas, Kotsinas, Athanassios, Laurent‐Puig, Pierre, López‐Ríos, Fernando, Hansen, Tine Plato, Rouleau, Etienne, Vandenberghe, Peter, Krieken, Johan J.M., Dequeker, Elisabeth

“…Learning Objectives After completing this course, the reader will be able to: Identify the most frequent errors made in KRAS testing in this study and the…”
Get full text

Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer by Song, Dongweon, Chaerkady, Raghothama, Tan, Aik Choon, García-García, Elena, Nalli, Anuradha, Suárez-Gauthier, Ana, López-Ríos, Fernando, Zhang, Xian Feng, Solomon, Anna, Tong, Jeffrey, Read, Margaret, Fritz, Christian, Jimeno, Antonio, Pandey, Akhilesh, Hidalgo, Manuel

“…Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in…”
Get full text

Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids by López-Ríos, Fernando, Illei, Peter B, Rusch, Valerie, Ladanyi, Marc

“…PCR-based evidence of infection by simian virus 40 (SV40) has been reported in varying proportions of pleural mesotheliomas and other tumours, but data are…”
Get full text

Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure by Delgado, Juan F., Conde, Esther, Sánchez, Violeta, López-Ríos, Fernando, Gómez-Sánchez, Miguel A., Escribano, Pilar, Sotelo, Teresa, de la Cámara, Agustín Gómez, Cortina, José, de la Calzada, Carlos S.

“…Pulmonary hypertension (PHT) associated with chronic heart failure (CHF) is a risk factor of right ventricular failure after heart transplantation (HT). Our…”
Get full text

Hybridization for human epidermal growth factor receptor 2 testing in gastric carcinoma: a comparison of fluorescence in-situ hybridization with a novel fully automated dual-colour silver in-situ hybridization method by García-García, Elena, Gómez-Martín, Carlos, Angulo, Bárbara, Conde, Esther, Suárez-Gauthier, Ana, Adrados, Magdalena, Perna, Cristian, Rodríguez-Peralto, José Luis, Hidalgo, Manuel, López-Ríos, Fernando

“…García‐García E, Gómez‐Martín C, Angulo B, Conde E, Suárez‐Gauthier A, Adrados M, Perna C, Rodríguez‐Peralto J L, Hidalgo M & López‐Ríos F 
(2011)…”
Get full text

The use of P63 immunohistochemistry for the identification of squamous cell carcinoma of the lung by Conde, Esther, Angulo, Bárbara, Redondo, Pilar, Toldos, Oscar, García-García, Elena, Suárez-Gauthier, Ana, Rubio-Viqueira, Belén, Marrón, Carmen, García-Luján, Ricardo, Sánchez-Céspedes, Montse, López-Encuentra, Angel, Paz-Ares, Luis, López-Ríos, Fernando

“…While some targeted agents should not be used in squamous cell carcinomas (SCCs), other agents might preferably target SCCs. In a previous microarray study,…”
Get full text

The ALK translocation in advanced non-small-cell lung carcinomas: preapproval testing experience at a single cancer centre by Conde, Esther, Angulo, Bárbara, Izquierdo, Elisa, Muñoz, Luna, Suárez-Gauthier, Ana, Plaza, Carlos, Dominguez, Nuria, Torres, Maribel, Madrigal, Luis, Rubio-Viqueira, Belén, Belda-Iniesta, Cristobal, Hidalgo, Manuel, López-Ríos, Fernando

“…Aims To study the ALK translocation in patients with advanced non‐small‐cell lung carcinomas (NSCLCs) seen at a European cancer centre, and its association…”
Get full text

Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test by Rüschoff, Josef, Kerr, Keith M, Grote, Hans J, Middel, Peter, von Heydebreck, Anja, Alves, Venâncio A, Baldus, Stephan E, Büttner, Reinhard, Carvalho, Lina, Fink, Ludger, Jochum, Wolfram, Lo, Anthony W I, López-Ríos, Fernando, Marx, Alexander, Molina, Thierry J, Olszewski, Włodzimierz T, Rieker, Ralf J, Volante, Marco, Thunnissen, Erik, Wrba, Fritz, Celik, Ilhan, Störkel, Stephan

“…The addition of cetuximab to first-line chemotherapy substantially prolonged survival in patients with advanced non-small cell lung cancer whose tumors…”
Get full text

Variational formulation for fractional hyperbolic problems in the theory of viscoelasticity by Bravo-Castillero, Julián, López Ríos, Luis Fernando

“…In this article, a theoretical framework for problems involving fractional equations of hyperbolic type arising in the theory of viscoelasticity is presented…”
Get full text

Diagnostic procedures for non-small-cell lung cancer (NSCLC): recommendations of the European Expert Group by Dietel, Manfred, Bubendorf, Lukas, Dingemans, Anne-Marie C, Dooms, Christophe, Elmberger, Göran, García, Rosa Calero, Kerr, Keith M, Lim, Eric, López-Ríos, Fernando, Thunnissen, Erik, Van Schil, Paul E, von Laffert, Maximilian

“…There is currently no Europe-wide consensus on the appropriate preanalytical measures and workflow to optimise procedures for tissue-based molecular testing of…”
Get more information

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment by GARRALDA, Elena, PAZ, Keren, BRUCKHEIMER, Elizabeth, ANGIUOLI, Samuel V, CALLES, Antonio, DIAZ, Luis A, VELCULESCU, Victor E, VALENCIA, Alfonso, SIDRANSKY, David, HIDALGO, Manuel, LOPEZ-CASAS, Pedro P, JONES, Siân, KATZ, Amanda, KANN, Lisa M, LOPEZ-RIOS, Fernando, SARNO, Francesca, AL-SHAHROUR, Fátima, VASQUEZ, David

“…Current technology permits an unbiased massive analysis of somatic genetic alterations from tumor DNA as well as the generation of individualized mouse…”
Get full text

Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib by Yang, James C H, Brose, Marcia S, Castro, Gilberto, Kim, Edward S, Lassen, Ulrik N, Leyvraz, Serge, Pappo, Alberto, López-Ríos, Fernando, Reeves, John A, Fellous, Marc, Penault-Llorca, Frédérique, Rudzinski, Erin R, Tabatabai, Ghazaleh, Vassal, Gilles, Drilon, Alexander, Trent, Jonathan

“…Tropomyosin receptor kinase (TRK) fusion proteins resulting from neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare primary oncogenic drivers…”
Get full text