Search Results - "López‐Noriega, Livia"

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function by López-Noriega, Livia, Rutter, Guy A

“…Numerous studies have sought to decipher the genetic and other mechanisms contributing to β-cell loss and dysfunction in diabetes mellitus. However, we have…”
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Roles of extracellular vesicles associated non-coding RNAs in Diabetes Mellitus by Gauthier, Benoit R, Cobo-Vuilleumier, Nadia, López-Noriega, Livia

“…Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play important roles in a wide range of physiological and pathological…”
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Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes? by Lorenzo, Petra I, Cobo-Vuilleumier, Nadia, Martín-Vázquez, Eugenia, López-Noriega, Livia, Gauthier, Benoit R

“…Diabetes is a chronic metabolic disease caused by an absolute or relative deficiency in functional pancreatic β-cells that leads to defective control of blood…”
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Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice by López‐Noriega, Livia, Cobo‐Vuilleumier, Nadia, Narbona‐Pérez, Álvaro Jesús, Araujo‐Garrido, Juan Luis, Lorenzo, Petra Isabel, Mellado‐Gil, José Manuel, Moreno, José Carlos, Gauthier, Benoit R, Martín‐Montalvo, Alejandro

“…Background and Purpose Thyroid hormones induce several changes in whole body metabolism that are known to improve metabolic homeostasis. However, adverse side…”
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A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors by Jimenez-Moreno, Carmen Maria, Herrera-Gomez, Irene de Gracia, Lopez-Noriega, Livia, Lorenzo, Petra Isabel, Cobo-Vuilleumier, Nadia, Fuente-Martin, Esther, Mellado-Gil, Jose Manuel, Parnaud, Geraldine, Bosco, Domenico, Gauthier, Benoit Raymond, Martin-Montalvo, Alejandro

“…Successful normalization of blood glucose in patients transplanted with pancreatic islets isolated from cadaveric donors established the proof-of-concept that…”
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The PTGS2/COX2-PGE2 signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus by Martín-Vázquez, Eugenia, Cobo-Vuilleumier, Nadia, López-Noriega, Livia, Lorenzo, Petra I, Gauthier, Benoit R

“…Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, but also pathophysiological…”
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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus by Cobo-Vuilleumier, Nadia, Lorenzo, Petra I., Rodríguez, Noelia García, Herrera Gómez, Irene de Gracia, Fuente-Martin, Esther, López-Noriega, Livia, Mellado-Gil, José Manuel, Romero-Zerbo, Silvana-Yanina, Baquié, Mathurin, Lachaud, Christian Claude, Stifter, Katja, Perdomo, German, Bugliani, Marco, De Tata, Vincenzo, Bosco, Domenico, Parnaud, Geraldine, Pozo, David, Hmadcha, Abdelkrim, Florido, Javier P., Toscano, Miguel G., de Haan, Peter, Schoonjans, Kristina, Sánchez Palazón, Luis, Marchetti, Piero, Schirmbeck, Reinhold, Martín-Montalvo, Alejandro, Meda, Paolo, Soria, Bernat, Bermúdez-Silva, Francisco-Javier, St-Onge, Luc, Gauthier, Benoit R.

“…Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune…”
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Transient PAX8 Expression in Islets During Pregnancy Correlates With β-Cell Survival, Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus by Martin-Montalvo, Alejandro, López-Noriega, Livia, Jiménez-Moreno, Carmen, Herranz, Amanda, Lorenzo, Petra I, Cobo-Vuilleumier, Nadia, Tamayo, Alejandra, González-Guerrero, Cristian, Hofsteede, Jonathan S W R, Lebreton, Fanny, Bosco, Domenico, García Toscano, Miguel, Herranz, Lucrecia, Anselmo, Joao, Moreno, José Carlos, Gauthier, Benoit R

“…Transient expression was reported in mouse islets during gestation, whereas a genome-wide linkage and admixture mapping study highlighted as a candidate gene…”
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Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors by Martin-Montalvo, Alejandro, Lorenzo, Petra I, López-Noriega, Livia, Gauthier, Benoit R

“…Four members of the PAX family, PAX2, PAX4, PAX6 and PAX8 are known to be expressed in the pancreas. Accumulated evidences indicate that several pancreatic…”
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PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus by Mellado-Gil, José Manuel, Jiménez-Moreno, Carmen María, Martin-Montalvo, Alejandro, Alvarez-Mercado, Ana Isabel, Fuente-Martin, Esther, Cobo-Vuilleumier, Nadia, Lorenzo, Petra Isabel, Bru-Tari, Eva, de Gracia Herrera-Gómez, Irene, López-Noriega, Livia, Pérez-Florido, Javier, Santoyo-López, Javier, Spyrantis, Andreas, Meda, Paolo, Boehm, Bernhard O., Quesada, Ivan, Gauthier, Benoit R.

“…Aims/hypothesis A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular…”
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PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet by Lorenzo, Petra I., Fuente-Martín, Esther, Brun, Thierry, Cobo-Vuilleumier, Nadia, Jimenez-Moreno, Carmen María, G. Herrera Gomez, Irene, López Noriega, Livia, Mellado-Gil, José Manuel, Martin-Montalvo, Alejandro, Soria, Bernat, Gauthier, Benoit R.

“…PAX4 is a key regulator of pancreatic islet development whilst in adult acute overexpression protects β-cells against stress-induced apoptosis and stimulates…”
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The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity by Mellado-Gil, Jose M., Fuente-Martín, Esther, Lorenzo, Petra I., Cobo-Vuilleumier, Nadia, López-Noriega, Livia, Martín-Montalvo, Alejandro, Gómez, Irene de Gracia Herrera, Ceballos-Chávez, Maria, Gómez-Jaramillo, Laura, Campos-Caro, Antonio, Romero-Zerbo, Silvana Y., Rodríguez-Comas, Júlia, Servitja, Joan-Marc, Rojo-Martinez, Gemma, Hmadcha, Abdelkrim, Soria, Bernat, Bugliani, Marco, Marchetti, Piero, Bérmudez-Silva, Francisco J., Reyes, Jose C., Aguilar-Diosdado, Manuel, Gauthier, Benoit R.

“…HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the…”
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The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity by Lorenzo, Petra I, Martin Vazquez, Eugenia, López-Noriega, Livia, Fuente-Martín, Esther, Mellado-Gil, José M, Franco, Jaime M, Cobo-Vuilleumier, Nadia, Guerrero Martínez, José A, Romero-Zerbo, Silvana Y, Perez-Cabello, Jesús A, Rivero Canalejo, Sabrina, Campos-Caro, Antonio, Lachaud, Christian Claude, Crespo Barreda, Alejandra, Aguilar-Diosdado, Manuel, García Fuentes, Eduardo, Martin-Montalvo, Alejandro, Álvarez Dolado, Manuel, Martin, Franz, Rojo-Martinez, Gemma, Pozo, David, Bérmudez-Silva, Francisco J, Comaills, Valentine, Reyes, José C, Gauthier, Benoit R

“…We recently demonstrated that the 'Metabesity' factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as…”
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Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging by López-Noriega, Livia, Capilla-González, Vivian, Cobo-Vuilleumier, Nadia, Martin-Vazquez, Eugenia, Lorenzo, Petra Isabel, Martinez-Force, Enrique, Soriano-Navarro, Mario, García-Fernández, María, Romero-Zerbo, Silvana Yanina, Bermúdez-Silva, Francisco Javier, Díaz-Contreras, Irene, Sánchez-Cuesta, Ana, Santos-Ocaña, Carlos, Hmadcha, Abdelkrim, Soria, Bernat, Martín, Franz, Gauthier, Benoit Raymond, Martin-Montalvo, Alejandro

“…An inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed…”
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1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo by DELGADILLO SILVA, LUIS F., RUTTER, GUY A., CHABOSSEAU, PAULINE L., PROVENCHER-GIRARD, AUDREY, PRAT, ALEXANDRE, LOPEZ NORIEGA, LIVIA

“…β-cell coordination within the islet is critical for normal glucose-stimulated insulin secretion. Recently, we and others have identified a subpopulation of…”
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Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice by Akalestou, Elina, Suba, Kinga, Lopez-Noriega, Livia, Georgiadou, Eleni, Chabosseau, Pauline, Gallie, Alasdair, Wretlind, Asger, Legido-Quigley, Cristina, Leclerc, Isabelle, Salem, Victoria, Rutter, Guy A.

“…Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes,…”
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The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice by Georgiadou, Eleni, Haythorne, Elizabeth, Dickerson, Matthew T., Lopez-Noriega, Livia, Pullen, Timothy J., da Silva Xavier, Gabriela, Davis, Samuel P. X., Martinez-Sanchez, Aida, Semplici, Francesca, Rizzuto, Rosario, McGinty, James A., French, Paul M., Cane, Matthew C., Jacobson, David A., Leclerc, Isabelle, Rutter, Guy A.

“…Aims/hypothesis Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca 2+ uptake into pancreatic beta cell…”
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161-LB: Inhibition of Kidney SGLT2 Expression following Bariatric Surgery in Mice by AKALESTOU, ELINA, LOPEZ NORIEGA, LIVIA, CHABOSSEAU, PAULINE L., LECLERC, ISABELLE, RUTTER, GUY A.

“…Background: Bariatric surgery is known to improve glucose tolerance and weight loss, but can also cause a postprandial increase in renal glucose excretion…”
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Author Correction: Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice by Akalestou, Elina, Suba, Kinga, Lopez-Noriega, Livia, Georgiadou, Eleni, Chabosseau, Pauline, Gallie, Alasdair, Wretlind, Asger, Legido-Quigley, Cristina, Leclerc, Isabelle, Salem, Victoria, Rutter, Guy A.

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Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice by Akalestou, Elina, Lopez-Noriega, Livia, Christakis, Ioannis, Hu, Ming, Miras, Alexander D, Leclerc, Isabelle, Rutter, Guy A

“…Glucocorticoids produced by the adrenal cortex are essential for the maintenance of metabolic homeostasis. Glucocorticoid activation is catalysed by…”
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