Search Results - "López‐Giménez, Juan F"

Identification of a serotonin/glutamate receptor complex implicated in psychosis by Chan, Pokman, Ang, Rosalind L, Weisstaub, Noelia V, Callado, Luis F, Sealfon, Stuart C, Okawa, Yuuya, Meana, J. Javier, Gingrich, Jay A, López-Giménez, Juan F, Zhou, Mingming, Milligan, Graeme, Yuen, Tony, Filizola, Marta, González-Maeso, Javier

“…The psychosis associated with schizophrenia is characterized by alterations in sensory processing and perception. Some antipsychotic drugs were identified by…”
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Interclass GPCR heteromerization affects localization and trafficking by Toneatti, Rudy, Shin, Jong M, Shah, Urjita H, Mayer, Carl R, Saunders, Justin M, Fribourg, Miguel, Arsenovic, Paul T, Janssen, William G, Sealfon, Stuart C, López-Giménez, Juan F, Benson, Deanna L, Conway, Daniel E, González-Maeso, Javier

“…Membrane trafficking processes regulate G protein-coupled receptor (GPCR) activity. Although class A GPCRs are capable of activating G proteins in a monomeric…”
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Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function by Moreno, José L., Muguruza, Carolina, Umali, Adrienne, Mortillo, Steven, Holloway, Terrell, Pilar-Cuéllar, Fuencisla, Mocci, Giuseppe, Seto, Jeremy, Callado, Luis F., Neve, Rachael L., Milligan, Graeme, Sealfon, Stuart C., López-Giménez, Juan F., Meana, J. Javier, Benson, Deanna L., González-Maeso, Javier

“…Serotonin and glutamate G protein-coupled receptor (GPCR) neurotransmission affects cognition and perception in humans and rodents. GPCRs are capable of…”
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Evaluating the pharmacological response in fluorescence microscopy images: The Δm algorithm by Gómez, Ana I, Cruz, Marcos, López-Giménez, Juan F

“…Current drug discovery procedures require fast and effective quantification of the pharmacological response evoked in living cells by agonist compounds. In the…”
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Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia by Moreno, José L, Miranda-Azpiazu, Patricia, García-Bea, Aintzane, Younkin, Jason, Cui, Meng, Kozlenkov, Alexey, Ben-Ezra, Ariel, Voloudakis, Georgios, Fakira, Amanda K, Baki, Lia, Ge, Yongchao, Georgakopoulos, Anastasios, Morón, José A, Milligan, Graeme, López-Giménez, Juan F, Robakis, Nikolaos K, Logothetis, Diomedes E, Meana, J Javier, González-Maeso, Javier

“…Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) can form multiprotein complexes (heteromers), which can alter the…”
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His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics by Martín-Guerrero, Sandra M., Alonso, Paula, Iglesias, Alba, Cimadevila, Marta, Brea, José, Loza, M. Isabel, Casado, Pedro, Martín-Oliva, David, Cutillas, Pedro R., González-Maeso, Javier, López-Giménez, Juan F.

“…[Display omitted] Antipsychotic drugs remain the current standard for schizophrenia treatment. Although they directly recognize the orthosteric binding site of…”
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Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1-A2A Receptor Heteromers by Ciruela, Francisco, Casado, Vicent, Rodrigues, Ricardo J, Lujan, Rafael, Burgueno, Javier, Canals, Meritxell, Borycz, Janusz, Rebola, Nelson, Goldberg, Steven R, Mallol, Josefa, Cortes, Antonio, Canela, Enric I, Lopez-Gimenez, Juan F, Milligan, Graeme, Lluis, Carme, Cunha, Rodrigo A, Ferre, Sergi, Franco, Rafael

“…The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the present study, we demonstrate that heteromerization of adenosine…”
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Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells by Martín-Guerrero, Sandra M., Casado, Pedro, Muñoz-Gámez, José A., Carrasco, María-Carmen, Navascués, Julio, Cuadros, Miguel A., López-Giménez, Juan F., Cutillas, Pedro R., Martín-Oliva, David

“…Oxidative stress (OxS) is involved in the development of cell injures occurring in retinal diseases while Poly(ADP-ribose) Polymerase-1 (PARP-1) is a key…”
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Multiple conformations of 5-HT2A and 5-HT2C receptors in rat brain: an autoradiographic study with [125I](±)DOI by López-Giménez, Juan F., Vilaró, M. Teresa, Palacios, José M., Mengod, Guadalupe

“…Earlier autoradiographic studies with the 5-HT 2 receptor agonist [ 125 I](±)DOI in human brain showed unexpected biphasic competition curves for various 5-HT…”
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Serotonin 2C receptor knockout mice: Autoradiographic analysis of multiple serotonin receptors by López-Giménez, Juan F., Tecott, Laurence H., Palacios, José M., Mengod, Guadalupe, Vilaró, M. Teresa

“…Quantitative receptor autoradiography was used to study possible alterations of the densities of multiple serotonin (5‐HT) receptor subtypes and of serotonin…”
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Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies by López-Giménez, Juan F., Vilaró, M. Teresa, Palacios, José M., Mengod, Guadalupe

“…The anatomic distribution of serotonin 5‐HT2A receptors visualized with [3H]MDL100,907 and of their mRNA detected by in situ hybridization were studied in…”
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Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: Comparison with [3H]mesulergine binding sites and choline acetyltransferase mRNA by López-Giménez, Juan F., Mengod, Guadalupe, Palacios, José M., Vilaró, M. Teresa

“…The distribution of serotonin 5‐HT2C receptor mRNA in monkey brain was studied by in situ hybridization and compared with the distribution of [3H]mesulergine…”
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Opioid regulation of mu receptor internalisation: relevance to the development of tolerance and dependence by Lopez-Gimenez, Juan F, Milligan, Graeme

“…Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However,…”
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Evaluating the pharmacological response in fluorescence microscopy images: The [DELTA]m algorithm by Gómez, Ana I, Cruz, Marcos, López-Giménez, Juan F

“…Current drug discovery procedures require fast and effective quantification of the pharmacological response evoked in living cells by agonist compounds. In the…”
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Human striosomes are enriched in 5-HT2A receptors: autoradiographical visualization with [3H]MDL100,907, [125I](±)DOI and [3H]ketanserin by López-Giménez, Juan F., Mengod, Guadalupe, Palacios, José M., Vilaró, M. Teresa

“…5‐HT2A receptors have been visualized with [3H]MDL100,907 in selected human brain areas by autoradiography. These areas included caudate and putamen, nucleus…”
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Hallucinogens and Serotonin 5-HT 2A Receptor-Mediated Signaling Pathways by López-Giménez, Juan F, González-Maeso, Javier

“…The neuropsychological effects of naturally occurring psychoactive chemicals have been recognized for millennia. Hallucinogens, which include naturally…”
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Constitutive oligomerization of human D2 dopamine receptors expressed in Spodoptera frugiperda 9 (Sf9) and in HEK293 cells. Analysis using co-immunoprecipitation and time-resolved fluorescence resonance energy transfer by Gazi, Lucien, López-Giménez, Juan F, Rüdiger, Martin P, Strange, Philip G

“…Human D2Long (D2L) and D2Short (D2S) dopamine receptor isoforms were modified at their N-terminus by the addition of a human immunodeficiency virus (HIV) or a…”
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Analysis of Sp6 and Sp8 Protein‐Protein Interactions and DNA Binding during Limb Development by Ros, Marian, Pérez‐Gómez, Rocío, Fernández‐Guerrero, Marc, Zunzunegui, Sandra, Bell, Sheila, López‐Giménez, Juan F

“…Sp6 and Sp8, two members of the specificity protein (Sp) family of zinc‐finger transcription factors, are expressed in the limb ectoderm. Their importance in…”
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Endocytosis as a biological response in receptor pharmacology: evaluation by fluorescence microscopy by Campa, Víctor M, Capilla, Almudena, Varela, María J, de la Rocha, Arlet M Acanda, Fernandez-Troyano, Juan C, Barreiro, R Belén, Lopez-Gimenez, Juan F

“…The activation of G-protein coupled receptors by agonist compounds results in diverse biological responses in cells, such as the endocytosis process consisting…”
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Domain swapping in the human histamine H1 receptor by Bakker, Remko A, Dees, Guido, Carrillo, Juan J, Booth, Raymond G, López-Gimenez, Juan F, Milligan, Graeme, Strange, Philip G, Leurs, Rob

“…G-protein-coupled receptors (GPCRs) represent the largest family of receptors involved in transmembrane signaling. Although these receptors were generally…”
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