Search Results - "López‐Collazo, Eduardo"

Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences by López-Collazo, Eduardo, del Fresno, Carlos

“…Endotoxin tolerance was first described in a study that exposed animals to a sublethal dose of bacterial endotoxin. The animals subsequently survived a lethal…”
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Endotoxin tolerance and trained immunity: breaking down immunological memory barriers by López-Collazo, Eduardo, Del Fresno, Carlos

“…For decades, innate immune cells were considered unsophisticated first responders, lacking the adaptive memory of their T and B cell counterparts. However,…”
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A specific natural killer cells phenotypic signature associated to long term elite control of HIV infection by Rallón, Norma, Jiménez‐Carretero, Daniel, Restrepo, Clara, Ligos, José M., Valentín‐Quiroga, Jaime, Mahillo, Ignacio, Cabello, Alfonso, López‐Collazo, Eduardo, Sánchez‐Cabo, Fátima, Górgolas, Miguel, Estrada, Vicente, Benito, José M.

“…Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) that control HIV replication without therapy. Among the mechanisms involved…”
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Genetic errors of the human caspase recruitment domain–B-cell lymphoma 10–mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity by Pérez de Diego, Rebeca, PhD, Sánchez-Ramón, Silvia, MD, PhD, López-Collazo, Eduardo, PhD, Martínez-Barricarte, Rubén, PhD, Cubillos-Zapata, Carolina, PhD, Ferreira Cerdán, Antonio, MD, PhD, Casanova, Jean-Laurent, MD, PhD, Puel, Anne, PhD

“…Three members of the caspase recruitment domain (CARD) family of adaptors (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10…”
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Editorial: Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis by Del Fresno, Carlos, Schulte, Leon Nicolas, López-Collazo, Eduardo

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Age‐dependent hypoxia‐induced PD‐L1 upregulation in patients with obstructive sleep apnoea by Cubillos‐Zapata, Carolina, Balbás‐García, Cristina, Avendaño‐Ortiz, Jose, Toledano, Victor, Torres, Marta, Almendros, Isaac, Casitas, Raquel, Zamarrón, Ester, García‐Sánchez, Aldara, Feliu, Jaime, Aguirre, Luis A., Farre, Ramón, López‐Collazo, Eduardo, García‐Rio, Francisco

“…ABSTRACT Background and objective In obstructive sleep apnoea (OSA), intermittent hypoxia (IH) compromises immune surveillance through the upregulation of the…”
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Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients by del Fresno, Carlos, Garcia-Rio, Francisco, Gomez-Pina, Vanesa, Soares-Schanoski, Alessandra, Fernandez-Ruiz, Irene, Jurado, Teresa, Kajiji, Tasneem, Shu, Chen, Marin, Elvira, Gutierrez del Arroyo, Ana, Prados, Concepcion, Arnalich, Francisco, Fuentes-Prior, Pablo, Biswas, Subrha K, Lopez-Collazo, Eduardo

“…Monocyte exposure to LPS induces a transient state in which these cells are refractory to further endotoxin stimulation. This phenomenon, termed endotoxin…”
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Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Arévalo, Bárbara, Bedoya, Mauricio, Kiper, Aytug K., Vergara, Fernando, Ramírez, David, Mazola, Yuliet, Bustos, Daniel, Zúñiga, Rafael, Cikutovic, Rocio, Cayo, Angel, Rinné, Susanne, Ramirez-Apan, M. Teresa, Sepúlveda, Francisco V., Cerda, Oscar, López-Collazo, Eduardo, Decher, Niels, Zúñiga, Leandro, Gutierrez, Margarita, González, Wendy

“…Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series…”
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How do we manufacture clinical‐grade interleukin‐15–stimulated natural killer cell products for cancer treatment? by Fernández, Lucía, Leivas, Alejandra, Valentín, Jaime, Escudero, Adela, Corral, Dolores, de Paz, Raquel, Vela, Maria, Bueno, David, Rodríguez, Rebeca, Torres, Juan Manuel, Díaz‐Almirón, Mariana, López‐Collazo, Eduardo, Martinez‐Lopez, Joaquin, Pérez‐Martínez, Antonio

“…BACKGROUND Cancer immunotherapy involving natural killer (NK) cells has gained interest. Here we report two methods to obtain interleukin (IL)‐15–activated NK…”
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Metalloproteinases Shed TREM-1 Ectodomain from Lipopolysaccharide-Stimulated Human Monocytes by Gomez-Pina, Vanesa, Soares-Schanoski, Alessandra, Rodriguez-Rojas, Alexandro, del Fresno, Carlos, Garcia, Felipe, Vallejo-Cremades, Maria Teresa, Fernandez-Ruiz, Irene, Arnalich, Francisco, Fuentes-Prior, Pablo, Lopez-Collazo, Eduardo

“…Triggering receptors expressed on myeloid cell (TREM) proteins are a family of cell surface receptors that participate in diverse cellular processes such as…”
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Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation by Cubillos‐Zapata, Carolina, Martínez‐García, Miguel Ángel, Díaz‐García, Elena, Toledano, Victor, Campos‐Rodríguez, Francisco, Sánchez‐de‐la‐Torre, Manuel, Nagore, Eduardo, Martorell‐Calatayud, Antonio, Hernández Blasco, Luis, Pastor, Esther, Abad‐Capa, Jorge, Montserrat, Josep María, Cabriada‐Nuño, Valentín, Cano‐Pumarega, Irene, Corral‐Peñafiel, Jaime, Arias, Eva, Mediano, Olga, Somoza‐González, María, Dalmau‐Arias, Joan, Almendros, Isaac, Farré, Ramón, López‐Collazo, Eduardo, Gozal, David, García‐Río, Francisco

“…Midkine (MDK) might mediate the proangiogenic effect of intermittent hypoxia (IH) in patients with obstructive sleep apnea (OSA) and cutaneous melanoma (CM)…”
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Role of MMPs in orchestrating inflammatory response in human monocytes via a TREM-1-PI3K-NF-κB pathway by Gómez‐Piña, Vanesa, Martínez, Eriel, Fernández‐Ruíz, Irene, Fresno, Carlos, Soares‐Schanoski, Alessandra, Jurado, Teresa, Siliceo, María, Toledano, Victor, Fernández‐Palomares, Rosa, García‐Rio, Francisco, Arnalich, Francisco, Biswas, Subhra K., López‐Collazo, Eduardo

“…Sustained TREM‐1 blocks the progress of ET in monocytes indicating a role of MMPs in orchestrating inflammatory response. The MMPs constitute a family of…”
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The immune checkpoints storm in COVID‐19: Role as severity markers at emergency department admission by Avendaño‐Ortiz, José, Lozano‐Rodríguez, Roberto, Martín‐Quirós, Alejandro, Terrón, Verónica, Maroun‐Eid, Charbel, Montalbán‐Hernández, Karla, Valentín‐Quiroga, Jaime, García‐Garrido, Miguel Ángel, del Val, Elena Muñoz, del Balzo‐Castillo, Álvaro, Peinado, María, Gómez, Laura, Herrero‐Benito, Carmen, Rubio, Carolina, Casalvilla‐Dueñas, José Carlos, Gómez‐Campelo, Paloma, Pascual‐Iglesias, Alejandro, del Fresno, Carlos, Aguirre, Luis A., López‐Collazo, Eduardo

“…[...]their relevance are still being discussed.1 Patients with severe COVID-19 show an impairment of the immune system allowing secondary infections,2–5 and…”
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Tumor Cells Deactivate Human Monocytes by Up-Regulating IL-1 Receptor Associated Kinase-M Expression via CD44 and TLR4 by del Fresno, Carlos, Otero, Karel, Gomez-Garcia, Lourdes, Gonzalez-Leon, Maria Carmen, Soler-Ranger, Llanos, Fuentes-Prior, Pablo, Escoll, Pedro, Baos, Rosa, Caveda, Luis, Garcia, Felipe, Arnalich, Francisco, Lopez-Collazo, Eduardo

“…Although blood monocytes possess significant cytotoxic activity against tumor cells, tumor-infiltrating monocytes are commonly deactivated in cancer patients…”
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Prior SARS‐CoV‐2 infection balances immune responses triggered by four EMA‐approved COVID‐19 vaccines: An observational study by Lozano‐Rodríguez, Roberto, Terrón‐Arcos, Verónica, Montalbán‐Hernández, Karla, Casalvilla‐Dueñas, José Carlos, Bergón‐Gutierrez, Marta, Pascual‐Iglesias, Alejandro, Quiroga, Jaime Valentín, Aguirre, Luis A., Pérez de Diego, Rebeca, Vela‐Olmo, Carmen, López‐Morejón, Lissette, Martín‐Quirós, Alejandro, del Balzo‐Castillo, Álvaro, Peinado‐Quesada, María A., García‐Garrido, Miguel A., Gómez‐Lage, Laura, Herrero‐Benito, Carmen, Llorente‐Fernández, Irene, Martín‐Miguel, Gema, Torrejón, Margarita, Cubillos‐Zapata, Carolina, del Fresno, Carlos, Avendaño‐Ortiz, José, López‐Collazo, Eduardo

“…Other authors have reported that in natural infection anti-Spike RBD IgA antibodies showed to be the major responsible of the neutralizing ability in early…”
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Immune Response and COVID-19: A mirror image of Sepsis by López-Collazo, Eduardo, Avendaño-Ortiz, José, Martín-Quirós, Alejandro, Aguirre, Luis A

“…The emergence of SARS-CoV-2 virus and its associated disease COVID-19 have triggered significant threats to public health, in addition to political and social…”
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Daily Physical Activity in Patients with Chronic Obstructive Pulmonary Disease Is Mainly Associated with Dynamic Hyperinflation by Garcia-Rio, Francisco, Lores, Vanesa, Mediano, Olga, Rojo, Blas, Hernanz, Angel, Lopez-Collazo, Eduardo, Alvarez-Sala, Rodolfo

“…Although the major limitation to exercise performance in patients with COPD is dynamic hyperinflation, little is known about its relation to daily physical…”
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Response to Comment on “Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients” by García-Río, Franciso, del Fresno, Carlos, Fuentes-Prior, Pablo, López-Collazo, Eduardo

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Induction of Endotoxin Tolerance Delays Acute Rejection in a Hindlimb Transplantation Model in Rats by Rubio Yanchuck, Mónica, Toledano, Víctor, Bonastre, Jorge, Diez, Jesús, Aguirre, Luis, López-Collazo, Eduardo

“…Acute rejection is seen in 85 percent of composite vascular allogeneic transplants despite long-term immunosuppression. Recently, it was reported that the…”
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6-Methylprednisolone down-regulates IRAK-M in human and murine osteoclasts and boosts bone-resorbing activity: a putative mechanism for corticoid-induced osteoporosis by Soares-Schanoski, A, Gomez-Pina, V, del Fresno, C, Rodriguez-Rojas, A, Garcia, F, Glaria, A, Sanchez, M, Vallejo-Cremades, M T, Baos, R, Fuentes-Prior, P, Arnalich, F, Lopez-Collazo, E

“…Osteoclasts are large, multinucleated cells, which originate from the fusion of macrophages. They play a central role in bone development and remodeling via…”
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