Search Results - "López, José Luis Rosa"

Fenton Reaction-Generated Advanced Oxidation Protein Products Induces Inflammation in Human Embryonic Kidney Cells by Bochi, Guilherme Vargas, Torbitz, Vanessa Dorneles, Santos, Roberto Christ Vianna, Cubillos-Rojas, Monica, López, José Luis Rosa, Siebel, Anna Maria, Gomes, Patrícia, de Oliveira, Jarbas Rodrigues, Moresco, Rafael Noal

“…Fenton reaction is a new mechanism able to generate advanced oxidation protein products (AOPPs) by exposing the human serum albumin to the Fenton system. Here,…”
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Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling by Aquino-Martínez, Rubén, Artigas, Natalia, Gámez, Beatriz, Rosa, José Luis, Ventura, Francesc

“…Understanding the molecular events that regulate osteoblast differentiation is essential for the development of effective approaches to bone regeneration. In…”
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The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation by Schneider, Taiane, Martinez-Martinez, Arturo, Cubillos-Rojas, Monica, Bartrons, Ramon, Ventura, Francesc, Rosa, Jose Luis

“…The RAF/MEK/ERK cascade is a conserved intracellular signaling pathway that controls fundamental cellular processes including growth, proliferation,…”
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HERCing: Structural and Functional Relevance of the Large HERC Ubiquitin Ligases by García-Cano, Jesús, Martinez-Martinez, Arturo, Sala-Gaston, Joan, Pedrazza, Leonardo, Rosa, Jose Luis

“…Homologous to the E6AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-like domain-containing proteins (HERCs) belong to the…”
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HERCing: structural and functional relevance of the large HERC ubiquitin ligases by García-Cano, Jesús, Martinez-Martinez, Arturo, Sala-Gaston, Joan, Pedrazza, Leonardo, Rosa López, José Luis

“…Homologous to the E6AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-like domain-containing proteins (HERCs) belong to the…”
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Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification by Valer, José Antonio, Sánchez de Diego, Cristina, Gamez Molina, Beatriz, Mishina, Yuji, Rosa López, José Luis, Ventura Pujol, Francesc

“…Heterotopic ossification (HO) is the pathological formation of ectopic endochondral bone within soft tissues. HO occurs following mechanical trauma, burns, or…”
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Inhibition of phosphatidylinositol 3‐kinase α (PI3Kα) prevents heterotopic ossification by Valer, José Antonio, Sánchez‐de‐Diego, Cristina, Gámez, Beatriz, Mishina, Yuji, Rosa, José Luis, Ventura, Francesc

“…Heterotopic ossification (HO) is the pathological formation of ectopic endochondral bone within soft tissues. HO occurs following mechanical trauma, burns, or…”
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NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization by Cubillos-Rojas, Monica, Schneider, Taiane, Bartrons, Ramon, Ventura, Francesc, Rosa, Jose Luis

“…p53 is a transcription factor that regulates important cellular processes related to tumor suppression, including induction of senescence, apoptosis, and DNA…”
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Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway by Pedrazza, Leonardo, Cubillos-Rojas, Monica, de Mesquita, Fernanda Cristina, Luft, Carolina, Cunha, Aline Andrea, Rosa, Jose Luis, de Oliveira, Jarbas Rodrigues

“…Sepsis is a severe medical condition that ranks among the top 10 causes of death worldwide and which has permanently high incidence rates. Mesenchymal stem…”
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Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies by de Mesquita, Fernanda Cristina, Guixé-Muntet, Sergi, Fernández-Iglesias, Anabel, Maeso-Díaz, Raquel, Vila, Sergi, Hide, Diana, Ortega-Ribera, Martí, Rosa, José Luís, García-Pagán, Juan Carlos, Bosch, Jaime, de Oliveira, Jarbas Rodrigues, Gracia-Sancho, Jordi

“…Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed…”
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The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation by Schneider, Taiane, Martinez-Martinez, Arturo, Cubillos Rojas, Mónica, Bartrons Bach, Ramon, Ventura Pujol, Francesc, Rosa López, José Luis

“…The RAF/MEK/ERK cascade is a conserved intracellular signaling pathway that controls fundamental cellular processes including growth, proliferation,…”
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The p38α MAPK function in osteoprecursors is required for bone formation and bone homeostasis in adult mice by Rodríguez-Carballo, Edgardo, Gámez, Beatriz, Sedó-Cabezón, Lara, Sánchez-Feutrie, Manuela, Zorzano, Antonio, Manzanares-Céspedes, Cristina, Rosa, José Luis, Ventura, Francesc

“…p38 MAPK activity plays an important role in several steps of the osteoblast lineage progression through activation of osteoblast-specific transcription…”
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Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies by Mesquita, Fernanda Cristina de, Guixé Muntet, Sergi, Fernández Iglesias, Anabel, Maeso Díaz, Raquel, Vila, Sergi, Hide Alférez, Diana, Ortega Ribera, Martí, Rosa López, José Luis, García Pagán, Juan Carlos, Bosch i Genover, Jaume, Oliveira, Jarbas Rodrigues de, Gracia-Sancho, Jorge

“…Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed…”
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HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study by Ruiz, Rocío, Pérez Villegas, Eva María, Bachiller, Sara, Rosa López, José Luis, Armengol, José Ángel

“…The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like domain of the HERC1 protein, which…”
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The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination by Cubillos-Rojas, Monica, Schneider, Taiane, Hadjebi, Ouadah, Pedrazza, Leonardo, de Oliveira, Jarbas Rodrigues, Langa, Francina, Guénet, Jean-Louis, Duran, Joan, de Anta, Josep Maria, Alcántara, Soledad, Ruiz, Rocio, Pérez-Villegas, Eva María, Aguilar-Montilla, Francisco J, Carrión, Ángel M, Armengol, Jose Angel, Baple, Emma, Crosby, Andrew H, Bartrons, Ramon, Ventura, Francesc, Rosa, Jose Luis

“…A mutation in the HERC2 gene has been linked to a severe neurodevelopmental disorder with similarities to the Angelman syndrome. This gene codifies a protein…”
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Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway by Pedrazza, Leonardo, Cubillos Rojas, Mónica, Mesquita, Fernanda Cristina de, Luft, Carolina, Cunha, Aline Andrea, Rosa López, José Luis, Rodrigues de Oliveira, Jarbas

“…Background: Sepsis is a severe medical condition that ranks among the top 10 causes of death worldwide and which has permanently high incidence rates…”
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Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrity by Hoyo, Natalia López-Del, López-Begines, Santiago, Rosa, Jose Luis, Chen, Jeannie, Méndez, Ana

“…The neuronal calcium sensor proteins GCAPs (guanylate cyclase activating proteins) switch between Ca2+-free and Ca2+-bound conformational states and confer…”
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The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration by Gamell, Cristina, Susperregui, Antonio G, Bernard, Ora, Rosa, José Luis, Ventura, Francesc

“…Bone morphogenetic proteins (BMPs) have been shown to participate in the patterning and specification of several tissues and organs during development and to…”
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Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase by Mashimo, Tomoji, Hadjebi, Ouadah, Amair-Pinedo, Fabiola, Tsurumi, Toshiko, Langa, Francina, Serikawa, Tadao, Sotelo, Constantino, Guénet, Jean-Louis, Rosa, Jose Luis

“…The HERC gene family encodes proteins with two characteristic domains: HECT and RCC1-like. Proteins with HECT domains have been described to function as…”
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Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide by Siebel, Anna, Cubillos-Rojas, Monica, Santos, Roberto Christ, Schneider, Taiane, Bonan, Carla Denise, Bartrons, Ramon, Ventura, Francesc, Rodrigues de Oliveira, Jarbas, Rosa, Jose Luis

“…Cells respond to different kind of stress through the coordinated activation of signaling pathways such as MAPK or p53. To find which molecular mechanisms are…”
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