Search Results - "López, Joaquín Martinez"

Minimal Residual Disease Monitoring with Next-Generation Sequencing Methodologies in Hematological Malignancies by Sánchez, Ricardo, Ayala, Rosa, Martínez-López, Joaquín

“…Ultra-deep next-generation sequencing has emerged in recent years as an important diagnostic tool for the detection and follow-up of tumor burden in most of…”
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Clinical course and risk factors for mortality from COVID‐19 in patients with haematological malignancies by Sanchez‐Pina, José María, Rodríguez Rodriguez, Mario, Castro Quismondo, Nerea, Gil Manso, Rodrigo, Colmenares, Rafael, Gil Alos, Daniel, Paciello, Mari Liz, Zafra, Denis, Garcia‐Sanchez, Cristina, Villegas, Carolina, Cuellar, Clara, Carreño‐Tarragona, Gonzalo, Zamanillo, Irene, Poza, María, Iñiguez, Rodrigo, Gutierrez, Xabier, Alonso, Rafael, Rodríguez, Antonia, Folgueira, Maria Dolores, Delgado, Rafael, Ferrari, José Miguel, Lizasoain, Manuel, Aguado, José María, Ayala, Rosa, Martinez‐Lopez, Joaquín, Calbacho, María

“…Background The impact of coronavirus disease 2019 (COVID‐19) in haematological patients (HP) has not been comprehensively reported. Methods We analysed 39…”
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Increased von Willebrand factor antigen and low ADAMTS13 activity are related to poor prognosis in covid‐19 patients by Rodríguez Rodríguez, Mario, Castro Quismondo, Nerea, Zafra Torres, Denis, Gil Alos, Daniel, Ayala, Rosa, Martinez‐Lopez, Joaquín

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NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma by Leivas, Alejandra, Valeri, Antonio, Córdoba, Laura, García-Ortiz, Almudena, Ortiz, Alejandra, Sánchez-Vega, Laura, Graña-Castro, Osvaldo, Fernández, Lucía, Carreño-Tarragona, Gonzalo, Pérez, Manuel, Megías, Diego, Paciello, María Liz, Sánchez-Pina, Jose, Pérez-Martínez, Antonio, Lee, Dean A., Powell, Daniel J., Río, Paula, Martínez-López, Joaquín

“…CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when redirected…”
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Overcoming tumor resistance mechanisms in CAR-NK cell therapy by Valeri, Antonio, García-Ortiz, Almudena, Castellano, Eva, Córdoba, Laura, Maroto-Martín, Elena, Encinas, Jessica, Leivas, Alejandra, Río, Paula, Martínez-López, Joaquín

“…Despite the impressive results of autologous CAR-T cell therapy in refractory B lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster,…”
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Tocilizumab for the treatment of adult patients with severe COVID‐19 pneumonia: A single‐center cohort study by Fernández‐Ruiz, Mario, López‐Medrano, Francisco, Pérez‐Jacoiste Asín, María Asunción, Maestro de la Calle, Guillermo, Bueno, Héctor, Caro‐Teller, José Manuel, Catalán, Mercedes, Calle, Cristina, García‐García, Rocío, Gómez, Carlos, Laguna‐Goya, Rocío, Lizasoáin, Manuel, Martínez‐López, Joaquín, Origüen, Julia, Pablos, José Luis, Ripoll, Mar, San Juan, Rafael, Trujillo, Hernando, Lumbreras, Carlos, Aguado, José María

“…Coronavirus disease 2019 (COVID‐19) can lead to a massive cytokine release. The use of the anti‐interleukin‐6 receptor monoclonal antibody tocilizumab (TCZ)…”
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Multiple Myeloma Patients have a Specific Serum Metabolomic Profile that Changes after Achieving Complete Remission by PUCHADES-CARRASCO, Leonor, LECUMBERRI, Ramón, MARTINEZ-LOPEZ, Joaquín, LAHUERTA, Juan-José, MATEOS, María-Victoria, PROSPER, Felipe, SAN-MIGUEL, Jesús F, PINEDA-LUCENA, Antonio

“…Multiple myeloma remains an incurable disease. New approaches to develop better tools for improving patient prognostication and monitoring treatment efficacy…”
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Expression of p53 protein isoforms predicts survival in patients with multiple myeloma by Rojas, Elizabeta A., Corchete, Luis A., De Ramón, Cristina, Krzeminski, Patryk, Quwaider, Dalia, García‐Sanz, Ramón, Martínez‐López, Joaquín, Oriol, Albert, Rosiñol, Laura, Bladé, Joan, Lahuerta, Juan José, San Miguel, Jesús F., González, Marcos, Mateos, María Victoria, Bourdon, Jean‐Christophe, Misiewicz‐Krzeminska, Irena, Gutiérrez, Norma C.

“…Loss and/or mutation of the TP53 gene are associated with short survival in multiple myeloma, but the p53 landscape goes far beyond. At least 12 p53 protein…”
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A phase 3 trial of azacitidine versus a semi‐intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia by Vives, Susana, Martínez‐Cuadrón, David, Bergua Burgues, Juan, Algarra, Lorenzo, Tormo, Mar, Martínez‐Sánchez, María Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, López‐Lorenzo, José L., Gil, Cristina, Vidriales, Belén, Falantes, Jose F., Serrano, Alfons, Labrador, Jorge, Sayas, María J., Foncillas, María Á., Amador Barciela, María L., Olave, María Teresa, Colorado, Mercedes, Gascón, Adriana, Fernández, María Á., Simiele, Adriana, Pérez‐Encinas, Manuel M., Rodríguez‐Veiga, Rebeca, García, Olga, Martínez‐López, Joaquín, Barragán, Eva, Paiva, Bruno, Sanz, Miguel Á., Montesinos, Pau

“…BACKGROUND Options to treat elderly patients (≥65 years old) newly diagnosed with acute myeloid leukemia (AML) include intensive and attenuated chemotherapy,…”
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High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma by Paiva, Bruno, Gutiérrez, Norma C., Rosiñol, Laura, Vídriales, María-Belén, Montalbán, María-Ángeles, Martínez-López, Joaquín, Mateos, María-Victoria, Cibeira, María-Teresa, Cordón, Lourdes, Oriol, Albert, Terol, María-José, Echeveste, María-Asunción, de Paz, Raquel, de Arriba, Felipe, Palomera, Luis, de la Rubia, Javier, Díaz-Mediavilla, Joaquín, Sureda, Anna, Gorosquieta, Ana, Alegre, Adrian, Martin, Alejandro, Hernández, Miguel T., Lahuerta, Juan-José, Bladé, Joan, San Miguel, Jesús F.

“…The achievement of complete response (CR) after high-dose therapy/autologous stem cell transplantation (HDT/ASCT) is a surrogate for prolonged survival in…”
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Imaging and bone marrow assessments improve minimal residual disease prediction in multiple myeloma by Alonso, Rafael, Cedena, María Teresa, Gómez‐Grande, Adolfo, Ríos, Rafael, Moraleda, José María, Cabañas, Valentín, Moreno, María José, López‐Jiménez, Javier, Martín, Fernando, Sanz, Alejandro, Valeri, Antonio, Jiménez, Ana, Sánchez, Ricardo, Lahuerta, Juan José, Martínez‐López, Joaquín

“…The value of minimal residual disease (MRD) status by bone marrow and imaging analysis as independent prognostic factors has been well established in multiple…”
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Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer by Otero-Sobrino, Álvaro, Blanco-Carlón, Pablo, Navarro-Aguadero, Miguel Ángel, Gallardo, Miguel, Martínez-López, Joaquín, Velasco-Estévez, María

“…Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation…”
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Clinical characteristics, prognosis and treatment of myelofibrosis patients with severe thrombocytopenia by Hernández‐Boluda, Juan‐Carlos, Correa, Juan‐Gonzalo, Alvarez‐Larrán, Alberto, Ferrer‐Marín, Francisca, Raya, José‐María, Martínez‐López, Joaquín, Velez, Patricia, Pérez‐Encinas, Manuel, Estrada, Natalia, García‐Gutiérrez, Valentín, Fox, María‐Laura, Luño, Elisa, Kerguelen, Ana, Cuevas, Beatriz, Durán, María‐Antonia, Ramírez, María‐José, Gómez‐Casares, Maite, Mata‐Vázquez, María‐Isabel, Regadera, Anabel, Pereira, Arturo, Cervantes, Francisco

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Impact of genotype on leukaemic transformation in polycythaemia vera and essential thrombocythaemia by Alvarez‐Larrán, Alberto, Senín, Alicia, Fernández‐Rodríguez, Concepción, Pereira, Arturo, Arellano‐Rodrigo, Eduardo, Gómez, Montse, Ferrer‐Marin, Francisca, Martínez‐López, Joaquín, Camacho, Laura, Colomer, Dolors, Angona, Anna, Navarro, Blanca, Cervantes, Francisco, Besses, Carlos, Bellosillo, Beatriz, Hernández‐Boluda, Juan Carlos

“…Summary The influence of driver mutations on leukaemic transformation was analysed in 1747 patients with polycythaemia vera or essential thrombocythaemia. With…”
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A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline by Carreño-Tarragona, Gonzalo, Varghese, Leila N., Sebastián, Elena, Gálvez, Eva, Marín-Sánchez, Alberto, López-Muñoz, Nieves, Nam-Cha, Syonghyun, Martínez-López, Joaquín, Constantinescu, Stefan N., Sevilla, Julián, Ayala, Rosa

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Improving the prediction of acute myeloid leukaemia outcomes by complementing mutational profiling with ex vivo chemosensitivity by Onecha, Esther, Ruiz‐Heredia, Yanira, Martínez‐Cuadrón, David, Barragán, Eva, Martinez‐Sanchez, Pilar, Linares, María, Rapado, Inmaculada, Perez‐Oteyza, Jaime, Magro, Elena, Herrera, Pilar, Rojas, José Luis, Gorrochategui, Julián, Villoria, Jesús, Boluda, Blanca, Sargas, Claudia, Ballesteros, Joan, Montesinos, Pau, Martínez‐López, Joaquín, Ayala, Rosa

“…Summary Refractoriness to induction therapy and relapse after complete remission are the leading causes of death in patients with acute myeloid leukaemia…”
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Filanesib in combination with pomalidomide and dexamethasone in refractory MM patients: safety and efficacy, and association with alpha 1‐acid glycoprotein (AAG) levels. Phase Ib/II Pomdefil clinical trial conducted by the Spanish MM group by Ocio, Enrique M., Motlló, Cristina, Rodríguez‐Otero, Paula, Martínez‐López, Joaquín, Cejalvo, Mª José, Martín‐Sánchez, Jesús, Bladé, Joan, García‐Malo, Mª Dolores, Dourdil, Mª Victoria, García‐Mateo, Aránzazu, Arriba, Felipe, García‐Sanz, Ramón, Rubia, Javier, Oriol, Albert, Lahuerta, Juan‐José, San‐Miguel, Jesús F., Mateos, María‐Victoria

“…Summary This phase I/II trial evaluated the combination of the kinesin spindle protein inhibitor filanesib with pomalidomide and dexamethasone in relapsed or…”
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GMP-Compliant Manufacturing of NKG2D CAR Memory T Cells Using CliniMACS Prodigy by Fernández, Lucía, Fernández, Adrián, Mirones, Isabel, Escudero, Adela, Cardoso, Leila, Vela, María, Lanzarot, Diego, de Paz, Raquel, Leivas, Alejandra, Gallardo, Miguel, Marcos, Antonio, Romero, Ana Belén, Martínez-López, Joaquín, Pérez-Martínez, Antonio

“…Natural killer group 2D (NKG2D) is a natural killer (NK) cell-activating receptor that recognizes different stress-induced ligands that are overexpressed in a…”
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Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses by Rodríguez-García, Alba, Mennesson, Nicolas, Hernandez-Ibarburu, Gema, Morales, María Luz, Garderet, Laurent, Bouchereau, Lorine, Allain-Maillet, Sophie, Piver, Eric, Marbán, Irene, Rubio, David, Bigot-Corbel, Edith, Martínez-López, Joaquín, Linares, María, Hermouet, Sylvie

“…Subsets of multiple myeloma (MM) and monoclonal gammopathies of undetermined significance (MGUS) present with a monoclonal immunoglobulin specific for…”
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Evaluation of the potential therapeutic benefits of macrophage reprogramming in multiple myeloma by Gutiérrez-González, Alejandra, Martínez-Moreno, Mónica, Samaniego, Rafael, Arellano-Sánchez, Noemí, Salinas-Muñoz, Laura, Relloso, Miguel, Valeri, Antonio, Martínez-López, Joaquín, Corbí, Ángel L., Hidalgo, Andrés, García-Pardo, Ángeles, Teixidó, Joaquín, Sánchez-Mateos, Paloma

“…Tumor-associated macrophages (TAM) are important components of the multiple myeloma (MM) microenvironment that support malignant plasma cell survival and…”
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