Search Results - "López, Giselle Y"

Management of glioblastoma: State of the art and future directions by Tan, Aaron C., Ashley, David M., López, Giselle Y., Malinzak, Michael, Friedman, Henry S., Khasraw, Mustafa

“…Glioblastoma is the most common malignant primary brain tumor. Overall, the prognosis for patients with this disease is poor, with a median survival of <2…”
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Polio virotherapy targets the malignant glioma myeloid infiltrate with diffuse microglia activation engulfing the CNS by Yang, Yuanfan, Brown, Michael C, Zhang, Gao, Stevenson, Kevin, Mohme, Malte, Kornahrens, Reb, Bigner, Darell D, Ashley, David M, López, Giselle Y, Gromeier, Matthias

“…Abstract Background Malignant gliomas commandeer dense inflammatory infiltrates with glioma-associated macrophages and microglia (GAMM) promoting immune…”
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The genetic landscape of gliomas arising after therapeutic radiation by López, Giselle Y., Van Ziffle, Jessica, Onodera, Courtney, Grenert, James P., Yeh, Iwei, Bastian, Boris C., Clarke, Jennifer, Oberheim Bush, Nancy Ann, Taylor, Jennie, Chang, Susan, Butowski, Nicholas, Banerjee, Anuradha, Mueller, Sabine, Kline, Cassie, Torkildson, Joseph, Samuel, David, Siongco, Aleli, Raffel, Corey, Gupta, Nalin, Kunwar, Sandeep, Mummaneni, Praveen, Aghi, Manish, Theodosopoulos, Philip, Berger, Mitchel, Phillips, Joanna J., Pekmezci, Melike, Tihan, Tarik, Bollen, Andrew W., Perry, Arie, Solomon, David A.

“…Radiotherapy improves survival for common childhood cancers such as medulloblastoma, leukemia, and germ cell tumors. Unfortunately, long-term survivors suffer…”
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Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation by Wilfong, Erin M, Croze, Roxanne, Fang, Xiaohui, Schwede, Matthew, Niemi, Erene, López, Giselle Y, Lee, Jae-Woo, Nakamura, Mary C, Matthay, Michael A

“…Human mesenchymal stem/stromal cells (hMSCs) are a promising therapy for acute respiratory distress syndrome (ARDS) and other inflammatory conditions. While…”
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Occipital Headache in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) by Cordano, Christian, López, Giselle Y., Bollen, Andrew W., Nourbakhsh, Bardia

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Frequent Mutations of POT1 Distinguish Pulmonary Sarcomatoid Carcinoma From Other Lung Cancer Histologies by Shen, Erica, Xiu, Joanne, Bentley, Rex, López, Giselle Y., Walsh, Kyle M.

“…Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non–small-cell lung cancer (NSCLC) harboring mutations in many canonical NSCLC-driver genes (eg,…”
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Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche by Liu, Mengyi, Ji, Zhicheng, Jain, Vaibhav, Smith, Vanessa L, Hocke, Emily, Patel, Anoop P, McLendon, Roger E, Ashley, David M, Gregory, Simon G, López, Giselle Y

“…Glioblastoma (GBM) remains an untreatable malignant tumor with poor patient outcomes, characterized by palisading necrosis and microvascular proliferation…”
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Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population by Regal, Joshua A, Guerra García, María E, Jain, Vaibhav, Chandramohan, Vidyalakshmi, Ashley, David M, Gregory, Simon G, Thompson, Eric M, López, Giselle Y, Reitman, Zachary J

“…Gangliogliomas are brain tumors composed of neuron-like and macroglia-like components that occur in children and young adults. Gangliogliomas are often…”
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Publisher Correction: Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor‑like population by Regal, Joshua A, Guerra García, María E, Jain, Vaibhav, Chandramohan, Vidyalakshmi, Ashley, David M, Gregory, Simon G, Thompson, Eric M, López, Giselle Y, Reitman, Zachary J

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Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features by Safaee, Michael M, Jonzzon, Soren, López, Giselle Y, Asaikar, Shailesh, Tihan, Tarik, Glenn, Orit A, Gupta, Nalin

“…Calcifying pseudoneoplasms of the neuraxis (CAPNONs) are rare, nonneoplastic lesions of the CNS. Their radiographic features have been well described, with…”
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Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role by Ahn, Janice S, Petersen, Maureen, Friedman, Allan H, López, Edward M, Cummings, Thomas J, Buckley, Anne F, López, Giselle Y

“…A number of neoplasms of the central nervous system can demonstrate diffuse eosinophilic globules, known to be secretory products of the corresponding cell…”
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Papillary Glioneuronal Tumor With a Novel GPR37L1-PRKCA Fusion by Ahn, Janice S, Ervin, John, Cummings, Thomas J, López, Giselle Y, Wang, Shih-Hsiu J

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Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report by Fan, Joline M, Solomon, David A, López, Giselle Y, Hofmann, Jeffrey W, Colorado, Rene A, Kim, Anthony S, Meisel, Karl, Halabi, Cathra

“…Psoriasis is the most common chronic inflammatory condition involving the T helper cell system. Population studies have demonstrated that patients with…”
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Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas by GENGLIN JIN, REITMAN, Zachary J, BIGNER, Darell D, HAI YAN, DUNCAN, Christopher G, SPASOJEVIC, Ivan, GOODEN, David M, AHMED RASHEED, B, RUI YANG, LOPEZ, Giselle Y, YIPING HE, MCLENDON, Roger E

“…Point mutations at Arg132 of the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and result in a gain of function…”
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EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis by Feng, Haizhong, Lopez, Giselle Y, Kim, Chung Kwon, Alvarez, Angel, Duncan, Christopher G, Nishikawa, Ryo, Nagane, Motoo, Su, An-Jey A, Auron, Philip E, Hedberg, Matthew L, Wang, Lin, Raizer, Jeffery J, Kessler, John A, Parsa, Andrew T, Gao, Wei-Qiang, Kim, Sung-Hak, Minata, Mutsuko, Nakano, Ichiro, Grandis, Jennifer R, McLendon, Roger E, Bigner, Darell D, Lin, Hui-Kuan, Furnari, Frank B, Cavenee, Webster K, Hu, Bo, Yan, Hai, Cheng, Shi-Yuan

“…Aberrant activation of EGFR in human cancers promotes tumorigenesis through stimulation of AKT signaling. Here, we determined that the discoidina…”
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Mutant IDH1 is required for IDH1 mutated tumor cell growth by Jin, Genglin, Pirozzi, Christopher J, Chen, Lee H, Lopez, Giselle Y, Duncan, Christopher G, Feng, Jie, Spasojevic, Ivan, Bigner, Darell D, He, Yiping, Yan, Hai

“…Frequent somatic hotspot mutations in isocitrate dehydrogenase 1 (IDH1) have been identified in gliomas, acute myeloid leukemias, chondrosarcomas, and other…”
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Autoimmune pancerebellitis associated with pembrolizumab therapy by Vitt, Jeffrey R, Kreple, Collin, Mahmood, Nausheen, Dickerson, Elliot, Lopez, Giselle Y, Richie, Megan B

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Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target by Guo, Changcun, Pirozzi, Christopher J, Lopez, Giselle Y, Yan, Hai

“…Isocitrate dehydrogenases, IDH1 and IDH2, decarboxylate isocitrate to α-ketoglutarate (α-KG) and reduce NADP to NADPH. Point mutations of IDH1 and IDH2 have…”
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Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression by Lopez, Giselle Y., Oberheim Bush, Nancy Ann, Phillips, Joanna J., Bouffard, John-Paul, Moshel, Yaron A., Jaeckle, Kurt, Kleinschmidt-DeMasters, B. K., Rosenblum, Marc K., Perry, Arie, Solomon, David A.

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IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain by Lopez, Giselle Y, Reitman, Zachary J, Solomon, David, Waldman, Todd, Bigner, Darell D, McLendon, Roger E, Rosenberg, Steven A, Samuels, Yardena, Yan, Hai

“…Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide…”
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