Search Results - "Lê, Anh Dzung"

Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration by Garcia, Kristine L P, Coen, Kathy, Miksys, Sharon, Lê, Anh Dzung, Tyndale, Rachel F

“…The CYP2B enzyme is expressed in human and rat brain, and metabolizes many CNS-acting drugs. The gene that encodes human CYP2B6 is highly polymorphic, where…”
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The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats by Dzung Lê, Anh, Funk, Douglas, Harding, Stephen, Juzytsch, Walter, Fletcher, Paul J.

“…Rationale and objectives We previously showed that systemic administration of the prototypical alpha-2 noradrenaline (NA) receptor antagonist yohimbine…”
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Effect of food training and training dose on nicotine self-administration in rats by GARCIA, Kristine L. P, ANH DZUNG LÊ, TYNDALE, Rachel F

“…Few studies investigate factors that influence acquisition in nicotine self-administration (NSA), such as food training and training dose. Most have utilized…”
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Brain CYP2B induction can decrease nicotine levels in the brain by Garcia, Kristine L. P., Lê, Anh Dzung, Tyndale, Rachel F.

“…Nicotine can be metabolized by the enzyme CYP2B; brain CYP2B is higher in rats and monkeys treated with nicotine, and in human smokers. A 7‐day nicotine…”
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Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward by Lê Dzung, Anh, Funk, Douglas, Harding, Stephen, Juzytsch, Walter, Li, Zhaoxia, Fletcher, Paul J.

“…Rationale and objectives We previously found that the inhibition of median raphe nucleus (MRN) 5-HT transmission by local injections of a 5-HT1A agonist…”
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Effects of pharmacological stressors on c-fos and CRF mRNA in mouse brain: Relationship to alcohol seeking by Funk, Douglas, Li, Zhaoxia, Coen, Kathy, Lê, Anh Dzung

“…A marked heterogeneity exists among stressors in their ability to reinstate alcohol seeking in rats. We have reported that the pharmacological stressor…”
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Behavioural sensitization to alcohol: Bridging the gap between preclinical research and human models by Nona, Christina N., Hendershot, Christian S., Lê, Anh Dzung

“…Alcohol use disorder (AUD) is an increasingly prevalent disorder that contributes significantly to the global burden of disease. According to the incentive…”
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3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism by Gehlert, Donald R, Cippitelli, Andrea, Thorsell, Annika, Le, Anh Dzung, Hipskind, Philip A, Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J, Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Ciccocioppo, Roberto, Heilig, Markus

“…We describe a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with advantageous properties for clinical development, and its in vivo activity…”
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Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement by Fletcher, Paul J., Rizos, Zoë, Noble, Kevin, Soko, Ashlie D., Silenieks, Leo B., Lê, Anh Dzung, Higgins, Guy A.

“…The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT2A and 5-HT2C receptors, modulates dopamine…”
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Serotonin receptors as potential targets for modulation of nicotine use and dependence by Fletcher, Paul J, Lê, Anh Dzung, Higgins, Guy A

“…Nicotine use carries considerable health risks and plays a major role in a variety of diseases. Current pharmacological treatments to aid in smoking cessation…”
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Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats by ANH DZUNG LE, FUNK, Douglas, HARDING, Stephen, JUZYTSCH, W, FLETCHER, Paul J, SHAHAM, Yavin

“…We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol…”
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Prior, repeated exposure to cocaine potentiates locomotor responsivity to central injections of corticotropin-releasing factor (CRF) in rats by ERB, Suzanne, FUNK, Douglas, ANH DZUNG LE

“…There is considerable evidence that the stress-related neuropeptide, corticotropin-releasing factor (CRF), plays an important role in mediating behavioural…”
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Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes by Lewicky, Jordan D., Fraleigh, Nya L., Martel, Alexandrine L., Nguyen, Thi M.-D., Schiller, Peter W., Mousavifar, Leila, Roy, René, Le, Anh Dzung, Funk, Douglas, Le, Hoang-Thanh

“…Peptide therapeutics offer numerous advantages in the treatment of diseases and disorders of the central nervous system (CNS). However, they are not without…”
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Increased Impulsivity After Injected Alcohol Predicts Later Alcohol Consumption in Rats: Evidence for "Loss-of-Control Drinking" and Marked Individual Differences by Poulos, Constantine X, Parker, Jayson L, Lê, Dzung Anh

“…A delay-of-reward paradigm was used to assess impulsivity in rats. Previous research with this paradigm has found that normally occurring impulsivity scores…”
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Cocaine pre-exposure enhances CRF-induced expression of c-fos mRNA in the central nucleus of the amygdala: An effect that parallels the effects of cocaine pre-exposure on CRF-induced locomotor activity by Erb, Suzanne, Funk, Douglas, Lê, Anh Dzung

“…There is evidence that cocaine pre-exposure produces changes in the responsivity of central corticotropin-releasing factor (CRF) systems and that these systems…”
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Stress Enhancement of Craving During Sobriety: A Risk for Relapse by Breese, George R., Chu, Kathleen, Dayas, Christopher V., Funk, Douglas, Knapp, Darin J., Koob, George F., Lê, Dzung Anh, O'Dell, Laura E., Overstreet, David H., Roberts, Amanda J., Sinha, Rajita, Valdez, Glenn R., Weiss, Friedbert

“…This report of the proceedings of a symposium presented at the 2004 Research Society on Alcoholism Meeting provides evidence linking stress during sobriety to…”
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The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm by Lê, A D, Poulos, C X, Quan, B, Chow, S

“…The effects of naltrexone, naltrindole (a selective delta opiate receptor antagonist) and beta-funaltrexamine (beta-FNA; a selective mu opiate receptor…”
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Brain CYP2B induction can decrease nicotine levels in the brain: Brain CYP2B induction by Garcia, Kristine L. P., Lê, Anh Dzung, Tyndale, Rachel F.

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Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward by Dzung Lê, Anh, Funk, Douglas, Harding, Stephen, Juzytsch, Walter, Li, Zhaoxia, Fletcher, Paul J.

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Vasopressin opposes locomotor stimulation by ethanol, cocaine and amphetamine in mice by Chiu, Joanne, Kalant, Harold, Lê, Dzung Anh

“…The effects of arginine 8-vasopressin on the stimulation of locomotor activity induced by ethanol, cocaine and amphetamine were examined in DBA/2N mice…”
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