Search Results - "Lévesque, Lyne"

Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins by Matzat, Leah H, Berberoglu, Stephen, Lévesque, Lyne

“…Nuclear export of mRNAs is mediated by the Tap/Nxt1 pathway. Tap moves its RNA cargo through the nuclear pore complex by direct interaction with nucleoporin…”
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Ligand specific effects on aluminum incorporation and toxicity in neurons and astrocytes by Lévesque, Lyne, Mizzen, Craig A, McLachlan, Donald R, Fraser, Paul E

“…Aluminum is present in many manufactured foods and medicines and is added to drinking water for purification purposes. It has been proposed that aluminum is a…”
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NXT1 Is Necessary for the Terminal Step of Crm1-Mediated Nuclear Export by Black, Ben E., Holaska, James M., Lévesque, Lyne, Ossareh-Nazari, Batool, Gwizdek, Carol, Dargemont, Catherine, Paschal, Bryce M.

“…Soluble factors are required to mediate nuclear export of protein and RNA through the nuclear pore complex (NPC). These soluble factors include receptors that…”
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Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex by Lévesque, Lyne, Bor, Yeou-Cherng, Matzat, Leah H, Jin, Li, Berberoglu, Stephen, Rekosh, David, Hammarskjöld, Marie-Louise, Paschal, Bryce M

“…Interactions between transport receptors and phenylalanine-glycine (FG) repeats on nucleoporins drive the translocation of receptor-cargo complexes through…”
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Identification of an NTF2-Related Factor That Binds Ran-GTP and Regulates Nuclear Protein Export by Black, Ben E., Lévesque, Lyne, Holaska, James M., Wood, Todd C., Paschal, Bryce M.

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RanGTP-Binding Protein NXT1 Facilitates Nuclear Export of Different Classes of RNA In Vitro by Ossareh-Nazari, B, Maison, C, Black, B E, Lévesque, L, Paschal, B M, Dargemont, C

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Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins by De Strooper, Bart, Beullens, Monique, Contreras, Bart, Levesque, Lyne, Craessaerts, Katleen, Cordell, Barbara, Moechars, Dieder, Bollen, Mathieu, Fraser, Paul, St. George-Hyslop, Peter, Van Leuven, Fred

“…Presenilins 1 and 2 are unglycosylated proteins with apparent molecular mass of 45 and 50 kDa, respectively, in transfected COS-1 and Chinese hamster ovary…”
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NXT1 (p15) Is a Crucial Cellular Cofactor in TAP-Dependent Export of Intron-Containing RNA in Mammalian Cells by Guzik, Brian W., Levesque, Lyne, Prasad, Susan, Bor, Yeou-Cherng, Black, Ben E., Paschal, Bryce M., Rekosh, David, Hammarskjöld, Marie-Louise

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Evidence for Phosphorylation and Oligomeric Assembly of Presenilin 1 by Seeger, Mary, Nordstedt, Christer, Petanceska, Suzana, Kovacs, Dora M., Gouras, Gunnar K., Hahne, Solveig, Fraser, Paul, Levesque, Lyne, Czernik, Andrew J., St George-Hyslop, Peter, Sisodia, Sangram S., Thinakaran, Gopal, Tanzi, Rudolph E., Greengard, Paul, Gandy, Sam

“…Pathogenic mutations in presenilin 1 (PS1) are associated with ≈ 50% of early-onset familial Alzheimer disease. PS1 is endoproteolytically cleaved to yield a…”
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Presenilin structure, function and role in Alzheimer disease by Fraser, Paul E., Yang, Dun-Sheng, Yu, Gang, Lévesque, Lyne, Nishimura, Masaki, Arawaka, Shigeki, Serpell, Louise C., Rogaeva, Ekaterina, St George-Hyslop, Peter

“…Numerous missense mutations in the presenilins are associated with the autosomal dominant form of familial Alzheimer disease. Presenilin genes encode polytopic…”
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RNA Export Mediated by Tap Involves NXT1-dependent Interactions with the Nuclear Pore Complex by Lévesque, L, Guzik, B, Guan, T, Coyle, J, Black, B E, Rekosh, D, Hammarskjöld, M L, Paschal, B M

“…Nuclear export of ribonucleoprotein complexes requires cis-acting signals and recognition by receptors that mediate translocation through the nuclear pore…”
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Glial expression of presenilin epitopes in human brain with cerebral infarction and in astrocytoma by MIAKE, H, TSUCHIYA, K, NAKAMURA, A, IKEDA, K, LEVESQUE, L, FRASER, P. E, HYSLOP, P. H. S.-G, MIZUSAWA, H, UCHIHARA, T

“…Presenilins, some gene mutations of which are associated with familial Alzheimer's disease (AD), are expressed mainly in neurons in normal brains and brains…”
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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing by St George-Hyslop, Peter, Levesque, Lyne, Supala, Agnes, Sato, Christine, Levitan, Diane, Zhang, Lili, Arawaka, Shigeki, Farrer, Lindsay, Kawarai, Toshitaka, Zhang, Dong Mei, Yu, Haung, Milman, Paul, Song, You-Qiang, Zhang, Yanni, Yu, Gang, Rogaev, Evgeny, Fraser, Paul, Xu, Dong Hong, Janus, Christopher, Smith, Marsha, Yang, Dun-Sheng, Liang, Yan, Holmes, Erin, Tandon, Anurag, Chen, Fusheng, Sorbi, Sandro, Aebersold, Ruedi, Nishimura, Masaki, Rogaeva, Ekaterina, Bruni, Amalia

“…Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2. Suppression of nicastrin expression in…”
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Resolution of allelic and non-allelic variants of histone H1 by cation-exchange-hydrophilic-interaction chromatography by Mizzen, Craig A, Alpert, Andrew J, Lévesque, Lyne, Kruck, Theo.P.A, McLachlan, Donald R

“…A mixed-mode high-performance liquid chromatography (HPLC) method that resolves the six known non-allelic variants of chicken erythrocyte histone H1 is…”
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Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons by Annaert, Wim G., Levesque, Lyne, Craessaerts, Kathleen, Dierinck, Inge, Snellings, Greet, Westaway, David, St. George-Hyslop, Peter, Cordell, Barbara, Fraser, Paul, de Strooper, Bart

“…Mutations of presenilin 1 (PS1) causing Alzheimer's disease selectively increase the secretion of the amyloidogenic βA4(1-42), whereas knocking out the gene…”
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Facioscapulohumeral Muscular Dystrophy Region Gene 1 Is a Dynamic RNA-Associated and Actin-Bundling Protein by Sun, Chia-Yun Jessica, van Koningsbruggen, Silvana, Long, Steven W., Straasheijm, Kirsten, Klooster, Rinse, Jones, Takako I., Bellini, Michel, Levesque, Lyne, Brieher, William M., van der Maarel, Silvère M., Jones, Peter L.

“…FSHD region gene 1 (FRG1) is a dynamic nuclear and cytoplasmic protein that, in skeletal muscle, shows additional localization to the sarcomere. Maintaining…”
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Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease by Mathews, P M, Cataldo, A M, Kao, B H, Rudnicki, A G, Qin, X, Yang, J L, Jiang, Y, Picciano, M, Hulette, C, Lippa, C F, Bird, T D, Nochlin, D, Walter, J, Haass, C, Lévesque, L, Fraser, P E, Andreadis, A, Nixon, R A

“…Mutations in the presenilin proteins cause early-onset, familial Alzheimer's disease (FAD). We characterized the cellular localization and endoproteolysis of…”
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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin by Yu, G, Chen, F, Levesque, G, Nishimura, M, Zhang, D M, Levesque, L, Rogaeva, E, Xu, D, Liang, Y, Duthie, M, St George-Hyslop, P H, Fraser, P E

“…The presenilin (PS) genes associated with Alzheimer disease encode polytopic transmembrane proteins which undergo physiologic endoproteolytic cleavage to…”
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Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1 by Lévesque, L, Annaert, W, Craessaerts, K, Mathews, P M, Seeger, M, Nixon, R A, Van Leuven, F, Gandy, S, Westaway, D, St George-Hyslop, P, De Strooper, B, Fraser, P E

“…Presenilins 1 (PS1) and 2 (PS2) are multispanning transmembrane proteins associated with familial Alzheimer disease (FAD). They are developmentally regulated,…”
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Maintenance of secretory responses following microencapsulation of rat islets of Langerhans by Levesque, Lyne

“…Islets were isolated by collagenase digestion following which one-half of the islets were encapsulated with an alginate-poly-L-lysine-alginate membrane. The…”
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