Search Results - "Létourneau, Richard"

Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study by Kindler, Hedy L, Dr, Ioka, Tatsuya, MD, Richel, Dirk J, MD, Bennouna, Jaafar, MD, Létourneau, Richard, MD, Okusaka, Takuji, MD, Funakoshi, Akihiro, MD, Furuse, Junji, MD, Park, Young Suk, MD, Ohkawa, Shinichi, MD, Springett, Gregory M, MD, Wasan, Harpreet S, MB, Trask, Peter C, PhD, Bycott, Paul, PhD, Ricart, Alejandro D, MD, Kim, Sinil, MD, Van Cutsem, Eric, MD

“…Summary Background Axitinib is a potent, selective inhibitor of vascular endothelial growth factor (VEGF) receptors 1, 2, and 3. A randomised phase 2 trial of…”
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Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study by Spano, Jean-Philippe, Prof, Chodkiewicz, Catherine, MD, Maurel, Joan, MD, Wong, Ralph, MD, Wasan, Harpreet, MD, Barone, Carlo, Prof, Létourneau, Richard, MD, Bajetta, Emilio, MD, Pithavala, Yazdi, PhD, Bycott, Paul, DrPh, Trask, Peter, PhD, Liau, Katherine, BS, Ricart, Alejandro D, MD, Kim, Sinil, MD, Rixe, Olivier, Prof

“…Summary Background Axitinib (AG-013736) is a potent and selective oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, which have an…”
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Prognostic value of CD73 expression in resected colorectal cancer liver metastasis by Messaoudi, Nouredin, Cousineau, Isabelle, Arslanian, Elizabeth, Henault, David, Stephen, David, Vandenbroucke-Menu, Franck, Dagenais, Michel, Létourneau, Richard, Plasse, Marylène, Roy, André, Lapointe, Réal, Ysebaert, Dirk, Trudel, Dominique, Soucy, Geneviève, Stagg, John, Turcotte, Simon

“…Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive…”
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Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns by Messaoudi, Nouredin, Henault, David, Stephen, David, Cousineau, Isabelle, Simoneau, Eve, Rong, Zhixia, Létourneau, Richard, Plasse, Marylène, Dagenais, Michel, Roy, André, Lapointe, Réal, Vandenbroucke-Menu, Franck, Kunda, Rastislav, Ysebaert, Dirk, Soucy, Geneviève, Stagg, John, Vermeulen, Peter, Turcotte, Simon

“…Background After resection, colorectal cancer liver metastases (CRLM) surrounded by a desmoplastic rim carry a better prognosis than the metastases replacing…”
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Homogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy by Henault, David, Stephen, David, St-Hilaire, Pierre-Antoine, Messaoudi, Nouredin, Vandenbroucke-Menu, Franck, Simoneau, Eve, Rong, Zhixia, Plasse, Marylène, Létourneau, Richard, Roy, André, Dagenais, Michel, Lapointe, Réal, Nguyen, Bich, Mes-Masson, Anne-Marie, Soucy, G., Turcotte, Simon

“…In colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex…”
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Effect of intraoperative hypovolemic phlebotomy on transfusion and clinical outcomes in patients undergoing hepatectomy: a retrospective cohort study by Al Khaldi, Maher, Gryspeerdt, Filip, Carrier, François Martin, Bouchard, Claudia, Simoneau, Ève, Rong, Zhixia, Plasse, Marylène, Létourneau, Richard, Dagenais, Michel, Roy, André, Lapointe, Réal, Massicotte, Luc, Vandenbroucke-Menu, Franck, Rioux-Massé, Benjamin, Turcotte, Simon

“…Background There is no consensus on how to best achieve a low central venous pressure during hepatectomy for the purpose of reducing blood loss and red blood…”
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When a Drain is the Culprit: An Unexpected Case of Small Bowel Obstruction with Biliary Peritonitis by Al Khaldi, Maher, Thibeault, Félix, Létourneau, Richard

“…Although postoperative abdominal drains are useful in therapeutic settings, their prophylactic role is debatable. We herein describe the case of a 30-year-old…”
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Portal vein embolization does not affect the long-term survival and risk of cancer recurrence among colorectal liver metastases patients: A prospective cohort study by Collin, Yves, Paré, Alex, Belblidia, Assia, Létourneau, Richard, Plasse, Marylène, Dagenais, Michel, Turcotte, Simon, Martel, Guillaume, Roy, André, Lapointe, Real, Vandenbroucke-Menu, Frank

“…Previous studies comparing the survival outcomes of liver resections with and without preoperative portal vein embolization (PVE) for colorectal liver…”
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Is intra-operative ultrasound still useful for the detection of a hepatic tumour in the era of modern pre-operative imaging? by D'Hondt, Mathieu, Vandenbroucke-Menu, Franck, Préville-Ratelle, Sébastien, Turcotte, Simon, Chagnon, Miguel, Plasse, Marylène, Létourneau, Richard, Dagenais, Michel, Roy, André, Lapointe, Réal

“…Abstract Background The current role of intra-operative ultrasound (IOUS) is questioned because of recent progress in medical imaging. The aim of the present…”
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Hypertrophy of the non-embolized liver after chemotherapy by Nafidi, Otmane, Désy, Delphine, Létourneau, Richard, Côté, Jean, Plasse, Marylène, Vandenbroucke, Franck, Roy, André, Dagenais, Michel, Lapointe, Réal W.

“…Neoadjuvant chemotherapy (NC+) and portal vein embolization (PVE) enables curative resection in more patients with colorectal-liver metastases (CRLM). However,…”
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Randomized Phase III Study of Exatecan and Gemcitabine Compared With Gemcitabine Alone in Untreated Advanced Pancreatic Cancer by ABOU-ALFA, Ghassan K, LETOURNEAU, Richard, O'REILLY, Eileen M, HARKER, Graydon, MODIANO, Manuel, HURWITZ, Herbert, TCHEKMEDYIAN, Nerses Simon, FEIT, Kevie, ACKERMAN, Judie, DE JAGER, Robert L, ECKHARDT, S. Gail

“…Exatecan mesylate is a hexacyclic, water-soluble, topoisomerase-1 inhibitor. Exatecan has single-agent and combination activity with gemcitabine in advanced…”
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Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience by Nassabein, Rami, Mansour, Laura, Richard, Corentin, Vandenbroucke-Menu, Franck, Aubin, Francine, Ayoub, Jean-Pierre, Dagenais, Michel, Lapointe, Real, Letourneau, Richard, Plasse, Marylène, Roy, André, Turcotte, Simon, Tehfe, Mustapha

“…Surgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of…”
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IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells by Kandere-Grzybowska, Kristiana, Letourneau, Richard, Kempuraj, Duraisamy, Donelan, Jill, Poplawski, Sarah, Boucher, William, Athanassiou, Achilles, Theoharides, Theoharis C

“…Fc epsilon RI cross-linkage in mast cells results in release of granule-associated mediators, such as histamine and proteases, as well as the production of…”
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Gastrointestinal stromal tumours: etiology, pathology and clinical management by Blackstein, Martin E, Dubé, Pierre, Fletcher, Jonathan A, Keller, Oliver R, Knowling, Margaret, Létourneau, Richard, Morris, Donald, Riddell, Robert, Rorke, Stewart, Swallow, Carol J

“…Investigation of the regulation of cell growth, differentiation and death by signalling pathways has led to a greater understanding of how alterations in these…”
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Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects by Theoharides, Theoharis C., K. Singh, Leena, Boucher, William, Pang, Xinzhu, Letourneau, Richard, Webster, Elizabeth, Chrousos, George

“…Abstract Mast cells are involved in atopic disorders, often exacerbated by stress, and are located perivascularly close to sympathetic and sensory nerve…”
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Transjugular intrahepatic portosystemic shunt before abdominal surgery in cirrhotic patients: a retrospective, comparative study by Vinet, Evelyne, Perreault, Pierre, Bouchard, Louis, Bernard, Denis, Wassef, Ramses, Richard, Carole, Létourneau, Richard, Pomier-Layrargues, Gilles

“…Surgery in cirrhotic patients is associated with high morbidity and mortality related to portal hypertension and liver insufficiency. Therefore, preoperative…”
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Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability by Alhelal, Mohammed A., DMD, Palaska, Iro, DMD, MSc, Panagiotidou, Smaro, MA, Letourneau, Richard, MA, Theoharides, Theoharis C., MS, PhD, MD

“…Abstract Background The nervous system contributes to the pathophysiology of allergic and inflammatory diseases, including oral inflammation. Mast cells (MCs)…”
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Acute Immobilization Stress Triggers Skin Mast Cell Degranulation via Corticotropin Releasing Hormone, Neurotensin, and Substance P: A Link to Neurogenic Skin Disorders by Singh, Leena K., Pang, Xinzhu, Alexacos, Nicholas, Letourneau, Richard, Theoharides, Theoharis C.

“…Many skin disorders, such as atopic dermatitis and psoriasis, worsen during stress and are associated with increased numbers and activation of mast cells which…”
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Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors by Singh, L K, Boucher, W, Pang, X, Letourneau, R, Seretakis, D, Green, M, Theoharides, T C

“…Urocortin (Ucn) is related to corticotropin-releasing hormone (CRH), and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors…”
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Pentosanpolysulfate inhibits mast cell histamine secretion and intracellular calcium ion levels: an alternative explanation of its beneficial effect in interstitial cystitis by Chiang, G, Patra, P, Letourneau, R, Jeudy, S, Boucher, W, Green, M, Sant, G R, Theoharides, T C

“…Mast cells are ubiquitous cells derived from the bone marrow and are responsible for allergic reactions as they release numerous vasodilatory, nociceptive and…”
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