Search Results - "Létard, S."

Activation of KIT modulates the function of tumor necrosis factor‐related apoptosis‐inducing ligand receptor (TRAIL‐R) in mast cells by Förster, A., Grotha, S. P., Seeger, J. M., Rabenhorst, A., Gehring, M., Raap, U., Létard, S., Dubreuil, P., Kashkar, H., Walczak, H., Roers, A., Hartmann, K.

“…Background Mastocytosis is characterized by the accumulation of mast cells (MCs) associated with activating mutations of KIT. Tumor necrosis factor‐related…”
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Single laser pulse induces spin state transition within the hysteresis loop of an Iron compound by Freysz, E., Montant, S., Létard, S., Létard, J.-F.

“…Within the thermal hysteresis loop of the [Fe(PM-BiA) 2(NCS) 2] compound, a single laser pulse of 14 mJ cm −2 induces a photo-conversion from the low spin (LS,…”
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Complete temperature study of the relaxation from the high-spin state to low-spin state in a strongly cooperative spin crossover compound by Degert, J., Lascoux, N., Montant, S., Létard, S., Freysz, E., Chastanet, G., Létard, J.-F.

“…Using two complementary techniques, the relaxation of a photo-induced spin state transition in a strongly cooperative compound has been studied from 10 to 170…”
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KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570 by Chaix, A, Arcangeli, M-L, Lopez, S, Voisset, E, Yang, Y, Vita, M, Letard, S, Audebert, S, Finetti, P, Birnbaum, D, Bertucci, F, Aurrand-Lions, M, Dubreuil, P, De Sepulveda, P

“…Mutation of KIT receptor tyrosine kinase at residue D816 results in ligand-independent constitutive kinase activity. This mutation occurs in most patients with…”
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Design, Synthesis, Structural and Nonlinear Optical Properties of Photochromic Crystals:  Toward Reversible Molecular Switches by Sliwa, Michel, Létard, Sylvie, Malfant, Isabelle, Nierlich, Martine, Lacroix, Pascal G, Asahi, Tsuyoshi, Masuhara, Hiroshi, Yu, Pei, Nakatani, Keitaro

“…Two new anil molecules exhibiting photochromism in the crystalline state, N-(4-hydroxy)-salicylidene-amino-4-(methylbenzoate) (2) and…”
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Spin Crossover Bistability in Three Mutually Perpendicular Interpenetrated (4,4) Nets by Moliner, Nicolás, Muñoz, Carmen, Létard, Sylvie, Solans, Xavier, Menéndez, Nieves, Goujon, Antoine, Varret, François, Real, José Antonio

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Suppressor of Cytokine Signaling 6 Associates with KIT and Regulates KIT Receptor Signaling by Bayle, Julie, Letard, Sébastien, Frank, Ronald, Dubreuil, Patrice, De Sepulveda, Paulo

“…Suppressor of cytokine signaling (SOCS) proteins are a family of Src homology 2-containing adaptor proteins. Cytokine-inducible Src homology domain…”
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Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model by Humbert, Martine, Castéran, Nathalie, Letard, Sébastien, Hanssens, Katia, Iovanna, Juan, Finetti, Pascal, Bertucci, François, Bader, Thomas, Mansfield, Colin D, Moussy, Alain, Hermine, Olivier, Dubreuil, Patrice

“…Tyrosine kinases are attractive targets for pancreatic cancer therapy because several are over-expressed, including PDGFRalpha/beta, FAK, Src and Lyn. A…”
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Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation by Zappulla, Jacques P, Dubreuil, Patrice, Desbois, Sabine, Létard, Sébastien, Hamouda, Nadine Ben, Daëron, Marc, Delsol, Georges, Arock, Michel, Liblau, Roland S

“…Mastocytosis is a rare neoplastic disease characterized by a pathologic accumulation of tissue mast cells (MCs). Mastocytosis is often associated with a…”
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Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms by ZERMATI, Yael, DE SEPULVEDA, Paulo, PARIZOT, Christophe, BIECHE, Yann, VIDAUD, Michel, LORTHOLARY, Olivier, AROCK, Michel, HERMINE, Olivier, DUBREUIL, Patrice, FEGER, Frederic, LETARD, Sebastion, KERSUAL, Joelle, CASTERAN, Nathalie, GOROCHOV, Guy, DY, Michel, DUMAS, Antoni Ribadeau, DORGHAM, Karim

“…Systemic mastocytosis (SM) is a rare disease caused by an abnormal mast cell accumulation in various tissues. Two classes of constitutive activating c-kit…”
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Critical temperature of the LIESST effect in iron(II) spin crossover compounds by Létard, Jean-François, Capes, Laurence, Chastanet, Guillaume, Moliner, Nicolas, Létard, Sylvie, Real, José-Antonio, Kahn, Olivier

“…The light-induced crossover in a series of iron(II) compounds has been investigated by irradiating the sample at 10 K with a Kr+ laser coupled to an optical…”
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Molecular Modeling of Wild-Type and D816V c-Kit Inhibition Based on ATP-Competitive Binding of Ellipticine Derivatives to Tyrosine Kinases by Vendôme, Jérémie, Letard, Sébastien, Martin, Frédéric, Svinarchuk, Fedor, Dubreuil, Patrice, Auclair, Christian, Le Bret, Marc

“…The D816V activating mutation of the c-Kit kinase domain often causes human mastocytosis. Although inhibitors of wild-type c-Kit are known (e.g. STI-571), they…”
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Signal transduction by several KIT juxtamembrane domain mutations by CASTERAN, Nathalie, DE SEPULVEDA, Paulo, BESLU, Nathalie, AOUBALA, Mustapha, LETARD, Sébastien, LECOCQ, Eric, ROTTAPEL, Robert, DUBREUIL, Patrice

“…Mutations of KIT receptor tyrosine kinase are found in the majority of patients with mastocytosis and in most gastrointestinal stromal tumors. Oncogenic KIT…”
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Oncogenic tyrosine kinase of malignant hemopathy targets the centrosome by DELAVAL, Bénédicte, LETARD, Sébastien, LELIEVRE, Hélène, CHEVRIER, Véronique, DAVIET, Laurent, DUBREUIL, Patrice, BIRNBAUM, Daniel

“…Myeloproliferative disorders (MPD) are malignant diseases of hematopoietic progenitor cells. Many MPDs result from a chromosomal translocation that creates a…”
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Mass Effect on the Equienergetic High-Spin/Low-Spin States of Spin-Crossover in 4,4‘-Bipyridine-Bridged Iron(II) Polymeric Compounds:  Synthesis, Structure, and Magnetic, Mössbauer, and Theoretical Studies by Moliner, Nicolás, Muñoz, M. Carmen, Létard, Sylvie, Salmon, Lionel, Tuchagues, Jean-Pierre, Bousseksou, Azzedine, Real, José Antonio

“…The suitability of the system [Fe(4,4‘-bipy)(H2O)2(NCX)2]·(4,4‘-bipy), where 4,4‘-bipy stands for 4,4‘-bipyridine and X = S (1) and Se (2), as a precursor for…”
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Spin-crossover in the [Fe(abpt) 2(NCX) 2] (X=S, Se) system: structural, magnetic, calorimetric and photomagnetic studies by Moliner, Nicolás, Muñoz, M.Carmen, Létard, Sylvie, Létard, Jean-François, Solans, Xavier, Burriel, Ramón, Castro, Miguel, Kahn, Olivier, Real, José Antonio

“…The compounds [Fe(abpt) 2(NCS) 2] ( 1) and [Fe(abpt) 2(NCSe) 2] ( 2) with abpt=4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole have been synthesized. The X-ray…”
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Rapamycin inhibits growth and survival of D-816-V-mutated c-kit mast cells by Gabillot-Carré, M., Lepelletier, Y., Humbert, M., de Sepuvelda, P., Ben Hamouda, N., Zappulla, J.P., Liblau, Roland, Ribadeau-Dumas, A., Machavoine, F., Letard, S., Baude, C., Hermant, A., Yang, Y., Vargaftig, J., Bodemer, C., Morelon, E., Lortholary, O., Recher, C., Laurent, G., Dy, M., Arock, M., Dubreuil, Pascal, Hermine, O.

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