Search Results - "Léon, Catherine"

Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells by Shin, Jae-Won, Buxboim, Amnon, Spinler, Kyle R., Swift, Joe, Christian, David A., Hunter, Christopher A., Léon, Catherine, Gachet, Christian, Dingal, P.C. Dave P., Ivanovska, Irena L., Rehfeldt, Florian, Chasis, Joel Anne, Discher, Dennis E.

“…Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by…”
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Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface by Nechipurenko, Dmitry Y, Receveur, Nicolas, Yakimenko, Alena O, Shepelyuk, Taisiya O, Yakusheva, Alexandra A, Kerimov, Roman R, Obydennyy, Sergei I, Eckly, Anita, Léon, Catherine, Gachet, Christian, Grishchuk, Ekaterina L, Ataullakhanov, Fazoil I, Mangin, Pierre H, Panteleev, Mikhail A

“…OBJECTIVE—After activation at the site of vascular injury, platelets differentiate into 2 subpopulations, exhibiting either proaggregatory or procoagulant…”
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Megakaryocytes use in vivo podosome‐like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids by Eckly, Anita, Scandola, Cyril, Oprescu, Antoine, Michel, Deborah, Rinckel, Jean‐Yves, Proamer, Fabienne, Hoffmann, David, Receveur, Nicolas, Léon, Catherine, Bear, James E., Ghalloussi, Dorsaf, Harousseau, Gabriel, Bergmeier, Wolfgang, Lanza, Francois, Gaits‐Iacovoni, Frédérique, Salle, Henri, Gachet, Christian

“…Background Blood platelets are anucleate cell fragments that prevent bleeding and minimize blood vessel injury. They are formed from the cytoplasm of…”
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Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix by Oprescu, Antoine, Michel, Déborah, Antkowiak, Adrien, Vega, Elodie, Viaud, Julien, Courtneidge, Sara A., Eckly, Anita, de la Salle, Henri, Chicanne, Gaëtan, Léon, Catherine, Payrastre, Bernard, Gaits-Iacovoni, Frédérique

“…Bone marrow megakaryocytes (MKs) undergo a maturation involving contacts with the microenvironment before extending proplatelets through sinusoids to deliver…”
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Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL by Cordeiro, Olga G, Chypre, Mélanie, Brouard, Nathalie, Rauber, Simon, Alloush, Farouk, Romera-Hernandez, Monica, Bénézech, Cécile, Li, Zhi, Eckly, Anita, Coles, Mark C, Rot, Antal, Yagita, Hideo, Léon, Catherine, Ludewig, Burkhard, Cupedo, Tom, Lanza, François, Mueller, Christopher G

“…Microenvironment and activation signals likely imprint heterogeneity in the lymphatic endothelial cell (LEC) population. Particularly LECs of secondary…”
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Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion by Léon, Catherine, Eckly, Anita, Hechler, Béatrice, Aleil, Boris, Freund, Monique, Ravanat, Catherine, Jourdain, Marie, Nonne, Christelle, Weber, Josiane, Tiedt, Ralph, Gratacap, Marie-Pierre, Severin, Sonia, Cazenave, Jean-Pierre, Lanza, François, Skoda, Radek, Gachet, Christian

“…Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand…”
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Broader expression of the mouse platelet factor 4‐cre transgene beyond the megakaryocyte lineage by Pertuy, F., Aguilar, A., Strassel, C., Eckly, A., Freund, J.‐N., Duluc, I., Gachet, C., Lanza, F., Léon, C.

“…Summary Background Transgenic mice expressing cre recombinase under the control of the platelet factor 4 (Pf4) promoter, in the context of a 100‐kb bacterial…”
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Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis by Aguilar, Alicia, Weber, Josiane, Boscher, Julie, Freund, Monique, Ziessel, Catherine, Eckly, Anita, Magnenat, Stéphanie, Bourdon, Catherine, Hechler, Béatrice, Mangin, Pierre H., Gachet, Christian, Lanza, François, Léon, Catherine

“…The biogenesis of lysosome related organelles is defective in Hermansky-Pudlak syndrome (HPS), a disorder characterized by oculocutaneous albinism and platelet…”
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Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome by Strassel, Catherine, Eckly, Anita, Leon, Catherine, Petitjean, Claire, Freund, Monique, Cazenave, Jean-Pierre, Gachet, Christian, Lanza, Francois

“…UMR-S949 INSERM, Université de Strasbourg, EFS-Alsace, Strasbourg, France Correspondence: François Lanza, INSERM U949, EFS-Alsace, 10 rue Spielmann 67000…”
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Interplay between P2Y1, P2Y12, and P2X1 receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling by Tolhurst, Gwen, Vial, Catherine, Léon, Catherine, Gachet, Christian, Evans, Richard J., Mahaut-Smith, Martyn P.

“…The difficulty of conducting electrophysiologic recordings from the platelet has restricted investigations into the role of ion channels in thrombosis and…”
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Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y1 receptor–null mice by Léon, Catherine, Hechler, Béatrice, Freund, Monique, Eckly, Anita, Vial, Catherine, Ohlmann, Philippe, Dierich, Andrée, LeMeur, Marianne, Cazenave, Jean-Pierre, Gachet, Christian

“…ADP is a key agonist in hemostasis and thrombosis. ADP-induced platelet activation involves the purinergic P2Y 1 receptor, which is responsible for shape…”
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The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation by HECHLER, B, LEON, C, VIAL, C, VIGNE, P, FRELIN, C, CAZENAVE, J.-P, GACHET, C

“…The human P2Y1 receptor heterologously expressed in Jurkat cells behaves as a specific adenosine 5'-diphosphate (ADP) receptor at which purified adenosine…”
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Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist by BAURAND, Anthony, RABOISSON, Pierre, FREUND, Monique, LEON, Catherine, CAZENAVE, Jean-Pierre, BOURGUIGNON, Jean-Jacques, GACHET, Christian

“…The effects of a potent P2Y1 receptor antagonist, N6-methyl-2'-deoxyadenosine-3',5'-bisphosphate (MRS2179) on adenosine-5'-diphosphate (ADP)-induced platelet…”
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Blood platelet formation at a glance by Boscher, Julie, Guinard, Ines, Eckly, Anita, Lanza, François, Léon, Catherine

“…The main function of blood platelets is to ensure hemostasis and prevent hemorrhages. The 10 platelets needed daily are produced in a well-orchestrated…”
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Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation by Bornert, Alicia, Boscher, Julie, Pertuy, Fabien, Eckly, Anita, Stegner, David, Strassel, Catherine, Gachet, Christian, Lanza, François, Léon, Catherine

“…Platelets are produced by bone marrow megakaryocytes through cytoplasmic protrusions, named native proplatelets (nPPT), into blood vessels. Proplatelets also…”
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Mechanical confinement prevents ectopic platelet release by Guinard, Ines, Brassard-Jollive, Noémie, Ruch, Laurie, Weber, Josiane, Eckly, Anita, Boscher, Julie, Léon, Catherine

“…Blood platelets are produced by megakaryocytes (MKs), their parent cells, which are in the bone marrow. Once mature, MK pierces through the sinusoid vessel,…”
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The platelet P2 receptors in arterial thrombosis by Gachet, Christian, Léon, Catherine, Hechler, Béatrice

“…ADP and ATP play a crucial role in hemostasis and thrombosis and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X 1…”
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Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation by Aguilar, Alicia, Pertuy, Fabien, Eckly, Anita, Strassel, Catherine, Collin, Dominique, Gachet, Christian, Lanza, François, Léon, Catherine

“…Megakaryocyte (MK) differentiation occurs within the bone marrow (BM), a complex 3-dimensional (3D) environment of low stiffness exerting local external…”
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Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties? by Baurand, Anthony, Eckly, Anita, Hechler, Béatrice, Kauffenstein, Gilles, Galzi, Jean-Luc, Cazenave, Jean-Pierre, Léon, Catherine, Gachet, Christian

“…In the present study, we investigated the desensitization and trafficking of the P2Y1 and P2Y12 receptors after agonist-induced stimulation of platelets or…”
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Biogenesis of the demarcation membrane system (DMS) in megakaryocytes by Eckly, Anita, Heijnen, Harry, Pertuy, Fabien, Geerts, Willie, Proamer, Fabienne, Rinckel, Jean-Yves, Léon, Catherine, Lanza, François, Gachet, Christian

“…The demarcation membrane system (DMS) in megakaryocytes forms the plasma membrane (PM) of future platelets. Using confocal microscopy, electron tomography, and…”
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