Search Results - "Léna, H."
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mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia
Published in The Journal of neuroscience (03-04-2019)“…Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) are focal malformations of cortical development (FMCDs) that are highly associated with…”
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Subject-specific muscle synergies in human balance control are consistent across different biomechanical contexts
Published in Journal of neurophysiology (01-06-2010)“…The musculoskeletal redundancy of the body provides multiple solutions for performing motor tasks. We have proposed that the nervous system solves this…”
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3
Neuromechanical Principles Underlying Movement Modularity and Their Implications for Rehabilitation
Published in Neuron (Cambridge, Mass.) (08-04-2015)“…Neuromechanical principles define the properties and problems that shape neural solutions for movement. Although the theoretical and experimental evidence is…”
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Muscle Synergies Characterizing Human Postural Responses
Published in Journal of neurophysiology (01-10-2007)“…The Wallace H. Coulter Department of Biomedical Engineering, at Georgia Tech and Emory University, Atlanta, Georgia Submitted 28 December 2006; accepted in…”
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Voluntary and reactive recruitment of locomotor muscle synergies during perturbed walking
Published in The Journal of neuroscience (29-08-2012)“…The modular control of muscles in groups, often referred to as muscle synergies, has been proposed to provide a motor repertoire of actions for the robust…”
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Long-term training modifies the modular structure and organization of walking balance control
Published in Journal of neurophysiology (01-12-2015)“…How does long-term training affect the neural control of movements? Here we tested the hypothesis that long-term training leading to skilled motor performance…”
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7
Common muscle synergies for balance and walking
Published in Frontiers in computational neuroscience (02-05-2013)“…Little is known about the integration of neural mechanisms for balance and locomotion. Muscle synergies have been studied independently in standing balance and…”
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EP-1168 Tumor regression on CBCT predicts the risk of recurrence and death in locally advanced non-small cell lung cancer
Published in Radiotherapy and oncology (01-04-2015)Get full text
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9
Prefilter Design for Improved Spectral Flatness of Physical Pseudorandom Perturbations
Published in IEEE transactions on control systems technology (01-05-2023)“…System identification techniques have been applied to model human sensorimotor systems for research and diagnostic purposes. Accurate human modeling via system…”
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Mechanisms of motor adaptation in reactive balance control
Published in PloS one (08-05-2014)“…Balance control must be rapidly modified to provide stability in the face of environmental challenges. Although changes in reactive balance over repeated…”
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Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies
Published in Frontiers in neuroanatomy (09-04-2021)“…Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a…”
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12
Millisecond Spike Timing Codes for Motor Control
Published in Trends in neurosciences (Regular ed.) (01-10-2018)“…Millisecond variations in spiking patterns can radically alter motor behavior, suggesting that traditional rate-based theories of motor control require…”
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13
Intrafusal cross‐bridge dynamics shape history‐dependent muscle spindle responses to stretch
Published in Experimental physiology (01-01-2024)“…Computational models can be critical to linking complex properties of muscle spindle organs to the sensory information that they encode during behaviours such…”
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14
Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin
Published in Journal of pineal research (01-04-2013)“…UV radiation (UVR) induces serious structural and functional alterations in human skin leading to skin aging and carcinogenesis. Reactive oxygen species are…”
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15
Ethnokinesiology: towards a neuromechanical understanding of cultural differences in movement
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (07-10-2024)“…Each individual's movements are sculpted by constant interactions between sensorimotor and sociocultural factors. A theoretical framework grounded in motor…”
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Increased neuromuscular consistency in gait and balance after partnered, dance-based rehabilitation in Parkinson's disease
Published in Journal of neurophysiology (01-07-2017)“…Here we examined changes in muscle coordination associated with improved motor performance after partnered, dance-based rehabilitation in individuals with mild…”
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An approximate stochastic optimal control framework to simulate nonlinear neuro-musculoskeletal models in the presence of noise
Published in PLoS computational biology (01-06-2022)“…Optimal control simulations have shown that both musculoskeletal dynamics and physiological noise are important determinants of movement. However, due to the…”
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18
Bidirectional dynamic scaling in an isolated Bose gas far from equilibrium
Published in Nature physics (01-04-2021)“…Understanding and classifying non-equilibrium many-body phenomena, analogously to the classification of equilibrium states of matter into universality classes…”
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Force encoding in muscle spindles during stretch of passive muscle
Published in PLoS computational biology (01-09-2017)“…Muscle spindle proprioceptive receptors play a primary role in encoding the effects of external mechanical perturbations to the body. During externally-imposed…”
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Worse balance is associated with larger perturbation-evoked cortical responses in healthy young adults
Published in Gait & posture (01-07-2020)“…•Young adults with worse balance have larger perturbation-evoked cortical responses.•EEG N1 response scaling to perturbation size is greater in those with…”
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